CPS1 gene expression

Stable Identifier
R-HSA-9959874
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytoplasm, nucleoplasm
ReviewStatus
3/5
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CPS1 gene expression
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CPS1 gene expression is repressed by the binding of TP53 tetramer to a binding site in its promoter (Li et al, 2019). Through transcriptional downregulation of urea cycle enzymes OTC, CPS1 and ARG1, TP53 increases cellular ammonia levels, ultimately leading to increased proliferation through elevated polyamine synthesis (Li et al, 2019; reviewed in Holbert et al, 2022). Elevated ammonia promotes increased translation of ornithine decarboxylase (ODC), the first and rate limiting enzyme in polyamine biosynthesis (Li et al, 2019; Dufe et al, 2007; Kanerva et al, 2008; reviewed in Holbert et al, 2022).
Literature References
PubMed ID Title Journal Year
30842655 p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis

Li, L, Mao, Y, Zhao, L, Li, L, Wu, J, Zhao, M, Du, W, Yu, L, Jiang, P

Nature 2019
17900240 Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase

Kanerva, K, Mäkitie, LT, Pelander, A, Heiskala, M, Andersson, LC

Biochem J 2008
35477776 Polyamines in cancer: integrating organismal metabolism and antitumour immunity

Holbert, CE, Cullen, MT, Casero, RA, Stewart, TM

Nat Rev Cancer 2022
17407445 A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane

Dufe, VT, Ingner, D, Heby, O, Khomutov, AR, Persson, L, al-Karadaghi, S

Biochem J 2007
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
TP53 tetramer:CPS1 gene [nucleoplasm] (Homo sapiens)
Active Unit
TP53 Tetramer [nucleoplasm]
Authored
Rothfels, K  (2025-07-02)
Created
Rothfels, K  (2025-07-02)
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