Cell-Cell communication

Stable Identifier
Homo sapiens
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Cell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell contacts mediated by receptors on their cell surfaces. Members of the immunoglobulin superfamily (IgSF) proteins are some of the cell surface receptors involved in cell-cell recognition, communication and many aspects of the axon guidance and synapse formation-the crucial processes during embryonal development (Rougon & Hobert 2003).

Processes annotated here as aspects of cell junction organization mediate the formation and maintenance of adherens junctions, tight junctions, and gap junctions, as well as aspects of cellular interactions with extracellular matrix and hemidesmosome assembly. Nephrin protein family interactions are central to the formation of the slit diaphragm, a modified adherens junction. Interactions among members of the signal regulatory protein family are important for the regulation of migration and phagocytosis by myeloid cells.

Literature References
PubMed ID Title Journal Year
16691243 The SIRP family of receptors and immune regulation

Barclay, AN, Brown, MH

Nat Rev Immunol 2006
1616050 Structure, function, and regulation of cellular tight junctions

Lynch, RD, Schneeberger, EE

Am J Physiol 1992
17766183 Nephrin--a unique structural and signaling protein of the kidney filter

Tryggvason, K, Patrakka, J

Trends Mol Med 2007
20554646 SIRP-alpha-CD47 system functions as an intercellular signal in the renal glomerulus

Kurihara, H, Sakai, T, Harita, Y, Ichimura, K, Hattori, S

Am J Physiol Renal Physiol 2010
12598678 New insights into the diversity and function of neuronal immunoglobulin superfamily molecules

Rougon, G, Hobert, O

Annu Rev Neurosci 2003
18837673 Dscam-mediated cell recognition regulates neural circuit formation

Hattori, D, Zipursky, SL, Millard, SS, Wojtowicz, WM

Annu Rev Cell Dev Biol 2008
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