GATA3, CHD4, EP300, and NFATC2 bind the IL13 gene

Stable Identifier
R-HSA-9976381
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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GATA3, CHD4, EP300, and NFATC2 bind the IL13 gene
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GATA3 and NFATC2 (NFAT1) bind upstream of the IL13 transcription start site (Yao et al. 2010, Kanhere et al. 2012, inferred from mouse homologs in Yamashita et al. 2002, Horiuchi et al. 2011, Wei et al. 2011, Hosokawa et al. 2013). In mice, Gata3, Chd4, and Ep300 form a complex that is bound to a Gata3-binding element located about 1.6 kb upstream of the Il13 gene (Yamashita et al. 2002, Hosokawa et al. 2013). NFATC2 binds to the IL13 promoter (393 to 65 bp upstream of the IL13 transcription start site) and this binding is enhanced by GATA3 expression, suggesting an interaction between GATA3 and NFATC2 (Yao et al. 2010).In humans, the IL4 and IL13 genes are located in the same gene cluster in chromosome region 5q31.1. GATA3 and NFATC2 interact with each other and bind within the IL4 and IL13 region to form a chromatin hub (Yao et al. 2012).
Literature References
PubMed ID Title Journal Year
20368097 GATA3 siRNA inhibits the binding of NFAT1 to interleukin-13 promoter in human T cells

Yao, X, Yang, Y, He, HY, Wang, M, Yin, KS, Huang, M

Chin Med J (Engl) 2010
23232398 T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements

Kanhere, A, Hertweck, A, Bhatia, U, Gökmen, MR, Perucha, E, Jackson, I, Lord, GM, Jenner, RG

Nat Commun 2012
22226971 Coordinated regulation of IL-4 and IL-13 expression in human T cells: 3C analysis for DNA looping

Yao, X, Zha, W, Song, W, He, H, Huang, M, Jazrawi, E, Lavender, P, Barnes, PJ, Adcock, IM, Durham, AL

Biochem Biophys Res Commun 2012
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Gata3, Chd4, Ep300, and Nfatc2 bind the Il13 gene (Mus musculus)
Authored
May, B  (2025-12-11)
Reviewed
Barbutti, I  (2026-02-24)
Lord, GM  (2026-02-26)
Created
May, B  (2025-12-11)
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