Gata3, Chd4, Ep300, and Nfatc2 bind the Il13 gene

Stable Identifier
R-MMU-9978103
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Gata3, Chd4, Ep300, and Nfatc2 bind the Il13 gene
Gata3 and Nfatc2 (Nfat1) bind upstream of the Il13 transcription start site (Yamashita et al. 2002, Horiuchi et al. 2011, Wei et al. 2011, Hosokawa et al. 2013). Gata3, Chd4, and Ep300 form a complex that is bound to a Gata3-binding element located about 1.6 kb upstream of the Il13 gene (Yamashita et al. 2002, Hosokawa et al. 2013). Nfatc2 binds within 393 to 65 bp upstream of the Il13 transcription start site and this binding is enhanced by Gata3 expression, suggesting an interaction between Gata3 and Nfatc2 (inferred from human homologs in Yao et al. 2010).
In mice, the IL4 and IL13 genes are located in the same gene cluster on chromosome 11. Gata3 and Nfatc2 interact with each other and bind within the Il4 and Il13 region to form a chromatin hub (inferred from human homologs in Yao et al. 2012).
Literature References
PubMed ID Title Journal Year
12205084 Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus

Yamashita, M, Ukai-Tadenuma, M, Kimura, M, Omori, M, Inami, M, Taniguchi, M, Nakayama, T

J Biol Chem 2002
23471993 Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity

Hosokawa, H, Tanaka, T, Suzuki, Y, Iwamura, C, Ohkubo, S, Endoh, K, Kato, M, Endo, Y, Onodera, A, Tumes, DJ, Kanai, A, Sugano, S, Nakayama, T

Proc Natl Acad Sci U S A 2013
21536806 Genome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3

Horiuchi, S, Onodera, A, Hosokawa, H, Watanabe, Y, Tanaka, T, Sugano, S, Suzuki, Y, Nakayama, T

J Immunol 2011
21867929 Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types

Wei, G, Abraham, BJ, Yagi, R, Jothi, R, Cui, K, Sharma, S, Narlikar, L, Northrup, DL, Tang, Q, Paul, WE, Zhu, J, Zhao, K

Immunity 2011
Participants
Input
Output
Orthologous Events
GATA3, CHD4, EP300, and NFATC2 bind the IL13 gene (Homo sapiens)
Authored
May, B  (2025-12-27)
Reviewed
Barbutti, I  (2026-02-24)
Lord, GM  (2026-02-26)
Created
May, B  (2025-12-27)
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