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p-S243-NFATC2 [nucleoplasm]
Stable Identifier
R-HSA-2025894
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nuclear factor of activated T-cells, cytoplasmic 2, NFAC2_HUMAN, NFATC2
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Calcineurin activates NFAT (Homo sapiens)
Calcineurin dephosphorylates NFATC1,2,3 (Homo sapiens)
Dephosphorylated NFATC1,2,3 [nucleoplasm] (Homo sapiens)
p-S243-NFATC2 [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)
Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
NFAT:CaN:CaM [nucleoplasm] (Homo sapiens)
Dephosphorylated NFATC1,2,3 [nucleoplasm] (Homo sapiens)
p-S243-NFATC2 [nucleoplasm] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
NFAT:CaN:CaM [nucleoplasm] (Homo sapiens)
Dephosphorylated NFATC1,2,3 [nucleoplasm] (Homo sapiens)
p-S243-NFATC2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13469 NFATC2
Gene Names
NFATC2, NFAT1, NFATP
Chain
chain:1-925
Reference Genes
BioGPS Gene:4773 NFATC2
COSMIC (genes):NFATC2 NFATC2
CTD Gene:4773 NFATC2
dbSNP Gene:4773 NFATC2
ENSEMBL:ENSG00000101096 NFATC2
HGNC:7776 NFATC2
KEGG:hsa:4773 NFATC2
Monarch:4773 NFATC2
NCBI Gene:4773 NFATC2
OMIM:600490 NFATC2
UCSC:Q13469 NFATC2
Reference Transcript
RefSeq:NM_001136021.2 NFATC2
RefSeq:NM_173091.3 NFATC2
RefSeq:NM_001258294.1 NFATC2
RefSeq:NM_012340.4 NFATC2
RefSeq:NM_001258292.1 NFATC2
RefSeq:NM_001258296.1 NFATC2
Participates
as a member of
Dephosphorylated NFATC1,2,3 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-14S-NFATC2 [cytosol]
p-S243-NFATC2 [cytosol]
NFATC2 [nucleoplasm]
Inferred From
p-S245-Nfatc2 [nucleoplasm]
(Mus musculus)
Inferred To
phospho-NFAT [nucleoplasm]
(Drosophila melanogaster)
phospho-NFATC2 [nucleoplasm]
(Bos taurus)
phospho-NFATC2 [nucleoplasm]
(Canis familiaris)
phospho-NFATC2 [nucleoplasm]
(Gallus gallus)
phospho-NFATC2 [nucleoplasm]
(Sus scrofa)
phospho-Nfatc2 [nucleoplasm]
(Mus musculus)
phospho-Nfatc2 [nucleoplasm]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-serine at 243
Coordinate
243
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
ENSEMBL
ENST00000396009
,
ENSP00000477342
,
ENST00000414705
,
ENST00000371564
,
ENSP00000396471
,
ENSP00000379330
,
ENSP00000360619
,
ENST00000609943
,
ENST00000609507
,
ENSP00000477370
,
ENST00000610033
,
ENSP00000477142
,
ENSG00000101096
OpenTargets
ENSG00000101096
GeneCards
NFATC2
HPA
ENSG00000101096-NFATC2
PRO
Q13469
Pharos - Targets
Q13469
GlyGen
Q13469
HMDB Protein
HMDBP01678
PDB
1PZU
,
1OWR
,
8R07
,
1S9K
,
1A02
,
1P7H
,
2AS5
,
8OW4
,
3QRF
,
8R3F
,
2O93
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86Y07-2 VRK2
2
VRK2-2 [cytosol]
(R-HSA-2995378)
VRK2-2 [nucleoplasm]
(R-HSA-2993893)
0.611
4
UniProt:Q86Y07-1 VRK2
0.611
3
IntAct:EBI-983681 ARRE2
0.591
5
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.558
3
UniProt:Q08209-1 PPP3CA
0.558
2
UniProt:IL2 ENSG00000109471
0.527
2
IntAct:EBI-10021565 CCL5-DERIVED
0.499
2
UniProt:P16220 CREB1
0.499
2
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