Dengue virus activates/modulates innate and adaptive immune responses

Stable Identifier
R-HSA-9920588
Type
Pathway
Species
Homo sapiens
Related Species
Dengue virus type 2
ReviewStatus
5/5
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Dengue virus activates/modulates innate and adaptive immune responses
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Dengue virus nonstructural protein NS1 interacts with several parts of the complement system. In addition, nonstructural proteins, as well as prM and C, bind factors of the host's type I interferon antiviral response (reviewed in Ramirez & Urcuqui-Inchima, 2015; Cumberworth et al. 2017). The overall picture is known from many expression studies. For general reviews about DENV subversion of innate immunity see Kao et al., 2018; Tremblay et al., 2019; Carr et al., 2020; Kraivong et al., 2021; Pan et al., 2022. DENV also employs various strategies to evade the adaptive immune system, including antigenic variation and inhibition of antigen presentation (reviewed in Lee et al., 2022).
Literature References
PubMed ID Title Journal Year
34202570 Dengue and the Lectin Pathway of the Complement System

Kraivong, R, Punyadee, N, Liszewski, MK, Atkinson, JP, Avirutnan, P

Viruses 2021
28273394 Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses

Cumberworth, SL, Clark, JJ, Kohl, A, Donald, CL

Cell Microbiol 2017
25629430 Dengue Virus Control of Type I IFN Responses: A History of Manipulation and Control

Castillo Ramirez, JA, Urcuqui-Inchima, S

J Interferon Cytokine Res 2015
31943152 Dengue virus and the complement alternative pathway

Carr, JM, Cabezas-Falcon, S, Dubowsky, JG, Hulme-Jones, J, Gordon, DL

FEBS Lett 2020
30564245 How Dengue Virus Circumvents Innate Immunity

Kao, YT, Lai, MMC, Yu, CY

Front Immunol 2018
31658677 The Interplay between Dengue Virus and the Human Innate Immune System: A Game of Hide and Seek

Tremblay, N, Freppel, W, Sow, AA, Chatel-Chaix, L

Vaccines (Basel) 2019
35154151 Flaviviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines

Pan, Y, Cai, W, Cheng, A, Wang, M, Yin, Z, Jia, R

Front Immunol 2022
36189361 Innate and adaptive immune evasion by dengue virus

Lee, MF, Voon, GZ, Lim, HX, Chua, ML, Poh, CL

Front Cell Infect Microbiol 2022
Participants
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Event Information
Go Biological Process
symbiont-mediated perturbation of host immune response (0052553)
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-09-01)
Reviewed
Roque Ascenção, F  (2025-10-29)
Mansur, DS  (2025-10-29)
Created
Stephan, R  (2024-09-02)
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