NS5 binds RBM10

Stable Identifier
R-HSA-9921721
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
nucleoplasm
ReviewStatus
5/5
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NS5 binds RBM10
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Nuclear DENV NS5 protein binds to RNA-binding protein 10 (RBM10), triggering its proteasome-mediated degradation. RBM10 depletion attenuates expression of interferon and pro-inflammatory cytokines (Pozzi et al., 2020).
Literature References
PubMed ID Title Journal Year
32432721 Dengue virus targets RBM10 deregulating host cell splicing and innate immune response

Pozzi, B, Bragado, L, Mammi, P, Torti, MF, Gaioli, N, Gebhard, LG, García Solá, ME, Vaz-Drago, R, Iglesias, NG, García, CC, Gamarnik, AV, Srebrow, A

Nucleic Acids Res 2020
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-09-12)
Reviewed
Roque Ascenção, F  (2025-10-29)
Mansur, DS  (2025-10-29)
Created
Stephan, R  (2024-09-13)
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