NS1 binds C1QA

Stable Identifier
R-HSA-9920638
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
extracellular region
ReviewStatus
5/5
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NS1 binds C1QA
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DENV-2 secreted NS1 protein can directly bind the complement protein C1q. This interaction is independent of posttranslational modification. It is unknown whether this interaction modulates complement activation. The direct binding was validated using NS1 from DENV-2 strain 16681, following an initial screen that used the NS1 gene from the DENV-2 NG-C strain (Silva et al., 2013).
Literature References
PubMed ID Title Journal Year
23516407 Mapping the interactions of dengue virus NS1 protein with human liver proteins using a yeast two-hybrid system: identification of C1q as an interacting partner

Silva, EM, Conde, JN, Allonso, D, Nogueira, ML, Mohana-Borges, R

PLoS One 2013
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-09-02)
Reviewed
Roque Ascenção, F  (2025-10-29)
Mansur, DS  (2025-10-29)
Created
Stephan, R  (2024-09-02)
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