DENV protease NS2B3 binds STING

Stable Identifier
R-HSA-3244618
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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DENV protease NS2B3 binds STING
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Dengue virus NS2B3 protease complex binds and subsequently cleaves the bound mediator of IRF3 activation (MITA, STING), blocking the activation of interferon regulatory factor 3 (IRF3) triggered by viral infection and by foreign DNA and RNA stimulation (Yu et al., 2012; Aguirre et al., 2012; Stabell et al., 2018; Su et al., 2020).
Literature References
PubMed ID Title Journal Year
32576686 DNA-induced 2'3'-cGAMP enhances haplotype-specific human STING cleavage by dengue protease

Su, CI, Kao, YT, Chang, CC, Chang, Y, Ho, TS, Sun, HS, Lin, YL, Lai, MMC, Liu, YH, Yu, CY

Proc Natl Acad Sci U S A 2020
29557779 Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir

Stabell, AC, Meyerson, NR, Gullberg, RC, Gilchrist, AR, Webb, KJ, Old, WM, Perera, R, Sawyer, SL

Elife 2018
22761576 Dengue virus targets the adaptor protein MITA to subvert host innate immunity

Yu, CY, Chang, TH, Liang, JJ, Chiang, RL, Lee, YL, Liao, CL, Lin, YL

PLoS Pathog. 2012
23055924 DENV inhibits type I IFN production in infected cells by cleaving human STING

Aguirre, S, Maestre, AM, Pagni, S, Patel, JR, Savage, T, Gutman, D, Maringer, K, Bernal-Rubio, D, Shabman, RS, Simon, V, Rodriguez-Madoz, JR, Mulder, LC, Barber, GN, Fernandez-Sesma, A

PLoS Pathog. 2012
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Shamovsky, V  (2013-02-06)
Reviewed
Roque Ascenção, F  (2025-10-29)
Mansur, DS  (2025-10-29)
Created
Shamovsky, V  (2013-03-28)
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