NS5 binds UBR4

Stable Identifier
R-HSA-9920957
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
cytosol
ReviewStatus
5/5
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NS5 binds UBR4
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Dengue virus (DENV) NS5 binds to the host protein UBR4, a predicted E3 ubiquitin-protein ligase. Morrison et al. 2013 show that NS5 serves as a bridge molecule between STAT2 and UBR4 and that UBR4 promotes DENV-mediated STAT2 degradation, a mechanism observed for all four DENV serotypes. This enhances the replication of DENV in an IFN-I-dependent manner in experiments using human and primate cells.
Literature References
PubMed ID Title Journal Year
23555265 Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling

Morrison, J, Laurent-Rolle, M, Maestre, AM, Rajsbaum, R, Pisanelli, G, Simon, V, Mulder, LC, Fernandez-Sesma, A, García-Sastre, A

PLoS Pathog 2013
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2024-09-05)
Reviewed
Roque Ascenção, F  (2025-10-29)
Mansur, DS  (2025-10-29)
Created
Stephan, R  (2024-09-05)
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