Reactome | CTLH E3 ligase ubiquitinates LDHA

CTLH E3 ligase ubiquitinates LDHA

Stable Identifier

R-HSA-9861563

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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CTLH E3 ligase complex transfers multiple ubiquitin (Ub) units onto LDHA, inhibiting lactate dehydrogenase activity. Which E2 enzyme and which ubiquitin linkage type are involved in these ubiquitination events remain an open question (Maitland et al., 2021). The CTLH complex consists of the proteins ARMC8, GID4, Muskelin, GID8, RANBP9, WDR26, and the catalytic subunits RMND5A or RMND5B and MAEA (Lampert et al., 2018; Maitland et al., 2019).

Literature References

PubMed ID	Title	Journal	Year
31285494	The mammalian CTLH complex is an E3 ubiquitin ligase that targets its subunit muskelin for degradation Maitland, MER, Onea, G, Chiasson, CA, Wang, X, Ma, J, Moor, SE, Barber, KR, Lajoie, GA, Shaw, GS, Schild-Poulter, C	Sci Rep	2019
34383978	Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex-dependent regulation of glycolysis Maitland, MER, Kuljanin, M, Wang, X, Lajoie, GA, Schild-Poulter, C	FASEB J	2021
29911972	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation Lampert, F, Stafa, D, Goga, A, Soste, MV, Gilberto, S, Olieric, N, Picotti, P, Stoffel, M, Peter, M	Elife	2018