NPM1-ALK-dependent TYK2 phosphorylation

Stable Identifier
R-HSA-9851114
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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NPM1-ALK-dependent TYK2 phosphorylation
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The JAK family member TYK2 is phosphorylated in anaplastic large cell lymphoma (ALCL) in both NPM1-ALK positive and ALK- cases. TYK2 phosphorylation promotes phosphorylation of both STAT1 and STAT3, although direct TYK2-mediated phosphorylation has not been demonstrated. Active TYK2 additionally contributes to increased expression of the pro-survival gene MCL1,. Consistent with this, knockdown of TYK2 induces death in human ALCL cell lines (Prutsch et al, 2019).
Literature References
PubMed ID Title Journal Year
30131584 Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma

Alvarez-Hernandez, A, Simonitsch-Klupp, I, Müller, M, Schlederer, M, Liang, HC, Wolf, P, Gurnhofer, E, Hielscher, T, Staber, PB, Sternberg, C, Svinka, J, Shirsath, N, Roos, S, Schmoellerl, J, Suske, T, Jäger, U, Leone, DA, Kornauth, C, Inghirami, GG, Eferl, R, Grebien, F, Prutsch, N, Aufinger, A, Moriggl, R, Strobl, B, Limberger, T, Stoiber, D, Wu, LC, Sanda, T, Look, AT, Turner, SD, Aberger, F, Kenner, L, Merkel, O

Leukemia 2019
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
IL22 [extracellular region] (Homo sapiens)
Regulator
IL10 [extracellular region] (Homo sapiens)
Regulator
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
Disease
Name Identifier Synonyms
anaplastic large cell lymphoma DOID:0050744
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2023-10-14)
Reviewed
Turner, S  (2023-11-08)
Created
Rothfels, K  (2023-10-12)
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