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NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol]
Stable Identifier
R-HSA-9699991
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
ALK fusion proteins bind IRS (Homo sapiens)
IRS- and FRS-binding ALK fusion proteins [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
IRS:ALK fusion proteins [cytosol] (Homo sapiens)
IRS- and FRS-binding ALK fusion proteins [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ALK fusion proteins bind PLCG1 (Homo sapiens)
GRB2- and PLC gamma-binding ALK fusion protein dimers [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
PLC gamma-binding ALK fusion proteins:PLCG1 [plasma membrane] (Homo sapiens)
GRB2- and PLC gamma-binding ALK fusion protein dimers [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ALK fusions bind FRS (Homo sapiens)
ALK fusions:FRS [cytosol] (Homo sapiens)
IRS- and FRS-binding ALK fusion proteins [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
IRS- and FRS-binding ALK fusion proteins [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ALK fusions bind GRB2 (Homo sapiens)
ALK fusion dimers:GRB2 [cytosol] (Homo sapiens)
GRB2- and PLC gamma-binding ALK fusion protein dimers [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
GRB2- and PLC gamma-binding ALK fusion protein dimers [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ALK fusions phosphorylate FRS (Homo sapiens)
ALK fusions:FRS [cytosol] (Homo sapiens)
IRS- and FRS-binding ALK fusion proteins [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ALK fusions:p-6Y FRS [cytosol] (Homo sapiens)
IRS- and FRS-binding ALK fusion proteins [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ALK fusions phosphorylate IRS1 (Homo sapiens)
IRS:ALK fusion proteins [cytosol] (Homo sapiens)
IRS- and FRS-binding ALK fusion proteins [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
p-Y IRS1:ALK fusion proteins [cytosol] (Homo sapiens)
IRS- and FRS-binding ALK fusion proteins [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ALK fusions phosphorylate PLCG1 (Homo sapiens)
ALK fusions:p-4Y PLCG1 [plasma membrane] (Homo sapiens)
GRB2- and PLC gamma-binding ALK fusion protein dimers [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
GRB2- and PLC gamma-binding ALK fusion protein dimers [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
PLC gamma-binding ALK fusion proteins:PLCG1 [plasma membrane] (Homo sapiens)
GRB2- and PLC gamma-binding ALK fusion protein dimers [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ALK mutants bind PI3KCA (Homo sapiens)
ALK mutants:PIK3R1 [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
PI3K-binding ALK fusions:PI3K [cytosol] (Homo sapiens)
ALK mutants:PIK3R1 [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ALK mutants bind PI3KR1 (Homo sapiens)
ALK mutants:PIK3R1 [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ALK mutants bind SHC (Homo sapiens)
ALK mutant dimers:SHC1 [cytosol] (Homo sapiens)
SHC-binding ALK mutant dimers [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
SHC-binding ALK mutant dimers [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ALK mutants bind STAT3 (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
STAT3-activating ALK mutants:STAT3 [cytosol] (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ALK mutants phosphorylate SHC1 (Homo sapiens)
ALK fusion dimers:p-3Y SHC1 [cytosol] (Homo sapiens)
SHC-binding ALK mutant dimers [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ALK mutant dimers:SHC1 [cytosol] (Homo sapiens)
SHC-binding ALK mutant dimers [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ALK mutants phosphorylate STAT3 (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
STAT3-activating ALK mutants:STAT3 [cytosol] (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
STAT3-activating ALK mutants:p-Y STAT3 [cytosol] (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ALK mutants:p-3Y SHC binds GRB2 (Homo sapiens)
ALK fusion dimers:p-3Y SHC1 [cytosol] (Homo sapiens)
SHC-binding ALK mutant dimers [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
ALK fusion dimers:p-3Y SHC1:GRB2 [cytosol] (Homo sapiens)
SHC-binding ALK mutant dimers [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
Autophosphorylation of ALK fusions (Homo sapiens)
p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
NPM1-ALK- and PI3K-dependent MDM2 phosphorylation (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer:PI3K [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
NPM1-ALK-dependent MAPK8,9 phosphorylation (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
NPM1-ALK-dependent TYK2 phosphorylation (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
NPM1-ALK translocates to the nucleus (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
PI3K synthesizes PIP3 downstream of ALK mutants (Homo sapiens)
PI3K-binding ALK fusions:PI3K [cytosol] (Homo sapiens)
ALK mutants:PIK3R1 [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
pY-STAT3 dimer translocates to the nucleus downstream of ALK mutants (Homo sapiens)
STAT3-activating ALK mutants:p-Y STAT3 [cytosol] (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)
Participants
components
x 2
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(Homo sapiens)
Participates
as an input of
NPM1-ALK translocates to the nucleus (Homo sapiens)
as a member of
SHC-binding ALK mutant dimers [cytosol] (Homo sapiens)
IRS- and FRS-binding ALK fusion proteins [cytosol] (Homo sapiens)
GRB2- and PLC gamma-binding ALK fusion protein dimers [cytosol] (Homo sapiens)
STAT3-activating ALK mutants [cytosol] (Homo sapiens)
p-7Y ALK fusion protein dimers [cytosol] (Homo sapiens)
PI3K-binding ALK mutants [cytosol] (Homo sapiens)
as a component of
NPM1(1-117)-p-7Y ALK(1058-1620) fusion dimer:PI3K [cytosol] (Homo sapiens)
This entity regulates
Positively
NPM1-ALK-dependent TYK2 phosphorylation
(Homo sapiens)
NPM1-ALK-dependent MAPK8,9 phosphorylation
(Homo sapiens)
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
lymphoma
DOID:0060058
lymphoid cancer
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