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IL22 [extracellular region]
Stable Identifier
R-HSA-448460
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interleukin-22, IL22_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
NPM1-ALK-dependent TYK2 phosphorylation (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-20 family signaling (Homo sapiens)
IL22 binds IL22RA1:JAK1 receptor complex (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
IL22:IL22RA1:JAK1 [plasma membrane] (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
IL22RA2:IL22 [extracellular region] (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
IL22:IL22RA1:JAK1 binds IL10RB:TYK2 (Homo sapiens)
IL22:IL22RA1:JAK1 [plasma membrane] (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
IL22:IL22RA1:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL22:IL22RA1:JAK1 [plasma membrane] (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 (Homo sapiens)
IL22:IL22RA1:JAK1:IL10RB:TYK2 [plasma membrane] (Homo sapiens)
IL22:IL22RA1:JAK1 [plasma membrane] (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA (Homo sapiens)
IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3 (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 binds STAT3 (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:STAT3 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
IL22:p‑Y251,p‑Y301‑IL22RA1:p‑JAK1:PTPN11:IL10RB:p‑TYK2 binds PTPN11 (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
IL22RA2 binds IL22 (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
IL22RA2:IL22 [extracellular region] (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
p-Y705-STAT3 dissociates from IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:p-Y705-STAT3 (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2:p-Y705-STAT3 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:PTPN11:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9GZX6 IL22
Gene Names
IL22, ILTIF, ZCYTO18, UNQ3099/PRO10096
Chain
signal peptide:1-33, chain:34-179
Reference Genes
BioGPS Gene:50616 IL22
COSMIC (genes):IL22 IL22
CTD Gene:50616 IL22
dbSNP Gene:50616 IL22
ENSEMBL:ENSG00000127318 IL22
ENSEMBL_homo_sapiens_GENE:ENSG00000127318.11 IL22
HGNC:14900 IL22
KEGG Gene (Homo sapiens):50616 IL22
Monarch:50616 IL22
NCBI Gene:50616 IL22
OMIM:605330 IL22
UCSC:Q9GZX6 IL22
Reference Transcript
RefSeq:NM_020525.4 IL22
Other Identifiers
11733737_at
16767261
221165_PM_s_at
221165_s_at
222974_PM_at
222974_at
3461147
3461148
3461150
3461152
3461153
3461154
3461155
3461156
3461157
50616
7964803
A_23_P427516
GE63369
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0006953
GO:0006954
GO:0007165
GO:0023052
GO:0045518
GO:0048018
GO:0050728
GO:0051384
GO:0098772
HMNXSV003016070
ILMN_1735208
ILMN_2100046
PH_hs_0014820
TC12001698.hg
TC12002949.hg
g10092624_3p_a_at
Participates
as an input of
IL22RA2 binds IL22 (Homo sapiens)
IL22 binds IL22RA1:JAK1 receptor complex (Homo sapiens)
as a component of
IL22RA2:IL22 [extracellular region] (Homo sapiens)
IL22:IL22RA1:JAK1 [plasma membrane] (Homo sapiens)
IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2 [plasma membrane] (Homo sapiens)
This entity regulates
Positively
NPM1-ALK-dependent TYK2 phosphorylation
(Homo sapiens)
Inferred To
IL22 [extracellular region]
(Bos taurus)
IL22 [extracellular region]
(Canis familiaris)
IL22 [extracellular region]
(Gallus gallus)
IL22 [extracellular region]
(Sus scrofa)
Il22 [extracellular region]
(Mus musculus)
Il22 [extracellular region]
(Rattus norvegicus)
LOC100216308 [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_065386.1
OpenTargets
ENSG00000127318
GeneCards
Q9GZX6
HPA
ENSG00000127318-IL22
Ensembl
ENSG00000127318
,
ENST00000328087
,
ENST00000538666
,
ENSP00000329384
,
ENSP00000442424
PRO
Q9GZX6
Pharos - Targets
Q9GZX6
PDB
1YKB
,
3G9V
,
3Q1S
,
3DGC
,
1M4R
,
3DLQ
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N6P7 IL22RA1
2
IL22RA1 [plasma membrane]
(R-HSA-448489)
p-Y-251,p-Y301-IL22RA1 [plasma membrane]
(R-HSA-8987198)
0.852
9
UniProt:Q08334 IL10RB
1
IL10RB [plasma membrane]
(R-HSA-448423)
0.589
2
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