Reactome | TYK2 [cytosol]

TYK2 [cytosol]

Stable Identifier

R-HSA-877348

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Non-receptor tyrosine-protein kinase TYK2, TYK2_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P29597 TYK2

Gene Names

TYK2

Chain

chain:1-1187

Reference Genes

BioGPS Gene:7297 TYK2

COSMIC (genes):TYK2 TYK2

CTD Gene:7297 TYK2

dbSNP Gene:7297 TYK2

ENSEMBL:ENSG00000105397 TYK2

ENSEMBL_homo_sapiens_GENE:ENSG00000105397.15 TYK2

HGNC:12440 TYK2

KEGG Gene (Homo sapiens):7297 TYK2

Monarch:7297 TYK2

NCBI Gene:7297 TYK2

OMIM:176941 TYK2

UCSC:P29597 TYK2

Reference Transcript

Other Identifiers

11757379_a_at

16868689

205546_PM_s_at

205546_s_at

3850280

3850281

3850282

3850284

3850288

3850290

3850292

3850294

3850295

3850296

3850298

3850300

3850301

3850302

3850304

3850307

3850308

3850309

3850310

3850311

3850313

3850314

3850315

3850316

3850317

3850318

3850319

3850320

3850321

3850325

3850326

3850327

3850328

7297

8033996

993_at

A_23_P153311

GE59795

GO:0000166

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005131

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006468

GO:0006955

GO:0007155

GO:0007259

GO:0009898

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0019221

GO:0019897

GO:0023052

GO:0030154

GO:0030155

GO:0031702

GO:0032729

GO:0032740

GO:0032819

GO:0035556

GO:0035722

GO:0036211

GO:0038196

GO:0042022

GO:0042102

GO:0043226

GO:0046427

GO:0051142

GO:0051239

GO:0060333

GO:0060337

GO:0060397

GO:0070062

GO:0072536

GO:0098542

GO:0098586

GO:0140096

GO:1900182

GO:2000318

HMNXSV003025674

ILMN_1676955

PH_hs_0004337

TC19001164.hg

X54637_at

g4507748_3p_a_at

Participates

as a component of

as an input of

as a candidate of

JAK1, JAK2, (TYK2) [cytosol] (Homo sapiens)

Other forms of this molecule

p-TYK2 [cytosol]

p-Y-TYK2 [cytosol]

p-Y1054,Y1055-TYK2 [cytosol]

p-Y1054-TYK2 [cytosol]

Inferred To

TYK2 [cytosol] (Bos taurus)

TYK2 [cytosol] (Canis familiaris)

TYK2 [cytosol] (Drosophila melanogaster)

TYK2 [cytosol] (Gallus gallus)

TYK2 [cytosol] (Mus musculus)

TYK2 [cytosol] (Rattus norvegicus)

TYK2 [cytosol] (Sus scrofa)

TYK2 [cytosol] (Xenopus tropicalis)

Ghost homologue of TYK2 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_003322.3, XP_011526547.1

ZINC - World Drugs

TYK2_HUMAN

Guide to Pharmacology - Targets

2269

OpenTargets

ENSG00000105397

ZINC - FDA approved

TYK2_HUMAN

ZINC - Substances

TYK2_HUMAN

ZINC - Biogenic

TYK2_HUMAN

ZINC target

P29597

PRO

P29597

PDB

8TB5, 4OLI, 6NZR, 4WOV, 4PY1, 5F20, 7UYR, 4PO6, 6DBK, 4GFO, 3ZON, 6NZE, 4GJ3, 3LXP, 5WAL, 6NZH, 3LXN, 7K7O, 7UYT, 7K7Q, 8S98, 7AX4, 7UYU, 6NZP, 6NZQ, 5C01, 6OVA, 6NSL, 6VNX, 4GIH, 5C03, 6VNY, 5TKD, 6X8F, 8TB6, 6X8G, 5F1Z, 8EXN, 6NZF, 7UYS, 6DBM, 8S99, 4GJ2, 3NYX, 6VNS, 4GVJ, 3NZ0, 6AAM, 6VNV, 4GII, 8EYC, 8S9A

ZINC - Investigational

TYK2_HUMAN

HPA

ENSG00000105397-TYK2

GeneCards

P29597

Ensembl

ENSP00000431885, ENST00000531836, ENSG00000105397, ENST00000525621, ENSP00000436175

Pharos - Targets

P29597

Orphanet

17260

ZINC - Predictions - Purchasable

TYK2_HUMAN

HMDB Protein

HMDBP01375

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.781	7
UniProt:Q13643 FHL3			0.718	6
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.666	4
UniProt:P52630 STAT2	4	p-Y690-STAT2 [cytosol] (R-HSA-909683) STAT2 [cytosol] (R-HSA-882029) p-Y690-STAT2 [nucleoplasm] (R-HSA-909673) p-Y-STAT2 [cytosol] (R-HSA-8987235)	0.641	4
UniProt:P17181 IFNAR1	2	IFNAR1 [plasma membrane] (R-HSA-877334) p-Y466,Y481-IFNAR1 [plasma membrane] (R-HSA-909675)	0.564	2
UniProt:P17181-1 IFNAR1			0.558	3
UniProt:Q3LI67 KRTAP6-3	1	KRTAP6-3 [cytosol] (R-HSA-6810281)	0.556	3
UniProt:Q05BL1 Q05BL1			0.556	3
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.556	3
UniProt:P61978-2 HNRNPK			0.556	3
UniProt:Q9NQX1-2 PRDM5			0.556	3
UniProt:Q9BUZ4 TRAF4			0.556	3
UniProt:O95994 AGR2			0.556	5
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:O75525 KHDRBS3	2	KHDRSB3 [nucleoplasm] (R-HSA-8849040) p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035)	0.556	3
UniProt:O75496 GMNN	2	GMNN [nucleoplasm] (R-HSA-113554) PolyUb-GMNN [nucleoplasm] (R-HSA-68585)	0.527	2
UniProt:P11912 CD79A	2	p-Y188,Y199-CD79A [plasma membrane] (R-HSA-983539) CD79A [plasma membrane] (R-HSA-197154)	0.527	2
UniProt:P24394 IL4R	2	IL4R [plasma membrane] (R-HSA-449670) p-Y-IL4R [plasma membrane] (R-HSA-6786087)	0.527	2
UniProt:P52799 EFNB2	2	p-Y311,Y316,Y330-EFNB2 [plasma membrane] (R-HSA-3928387) EFNB2 [plasma membrane] (R-HSA-2682330)	0.527	2
UniProt:P55286 CDH8	1	CDH8 [plasma membrane] (R-HSA-419000)	0.527	2
UniProt:Q8NFN8 GP156			0.527	2
UniProt:O43567 RNF13			0.527	3
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.527	2
UniProt:Q96FV0 LRC46			0.527	2
UniProt:Q8IYS4 DAAF8			0.527	2
UniProt:P06463 VE6			0.524	4
UniProt:P04019 VE6			0.524	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.524	2

Cite Us!