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TBX6 [nucleoplasm]
Stable Identifier
R-HSA-9793377
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
T-box transcription factor TBX6, TBX6_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Expression of DLL1 in paraxial mesoderm (Homo sapiens)
LEF1:CTNNB1:TBX6:DLL1 gene [nucleoplasm] (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
Expression of MSGN1 in paraxial mesoderm (Homo sapiens)
CTNNB1:LEF1:TBX6:MSGN1 gene [nucleoplasm] (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
Expression of TBX6 in paraxial mesoderm (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
Somitogenesis (Homo sapiens)
Expression of HES7 in presomitic mesoderm (Homo sapiens)
HES7:LEF1:CTNNB1:TBX6:RBPJ:NICD1:HES7 gene [nucleoplasm] (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
LEF1:CTNNB1:TBX6:RBPJ:NICD1:HES7 gene [nucleoplasm] (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
Expression of MESP2 in presomitic mesoderm (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
TBX6:MESP2 gene [nucleoplasm] (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
HES7 binds the HES7 gene (Homo sapiens)
HES7:LEF1:CTNNB1:TBX6:RBPJ:NICD1:HES7 gene [nucleoplasm] (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
LEF1:CTNNB1:TBX6:RBPJ:NICD1:HES7 gene [nucleoplasm] (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
LEF1:CTNNB1, NICD1 (NOTCH1) and TBX6 bind the HES7 gene in presomitic mesoderm (Homo sapiens)
LEF1:CTNNB1:TBX6:RBPJ:NICD1:HES7 gene [nucleoplasm] (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
TBX6 binds the MESP2 gene (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
TBX6:MESP2 gene [nucleoplasm] (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
TBX6 and LEF1:CTNNB1 bind the DLL1 gene (Homo sapiens)
LEF1:CTNNB1:TBX6:DLL1 gene [nucleoplasm] (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
TBX6 and LEF1:CTNNB1 bind the MSGN1 gene (Homo sapiens)
CTNNB1:LEF1:TBX6:MSGN1 gene [nucleoplasm] (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
Formation of the posterior neural plate (Homo sapiens)
Expression of SOX2 in posterior neural plate (Homo sapiens)
TBX6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95947 TBX6
Gene Names
TBX6
Chain
chain:1-436
Reference Genes
BioGPS Gene:6911 TBX6
COSMIC (genes):TBX6 TBX6
CTD Gene:6911 TBX6
dbSNP Gene:6911 TBX6
ENSEMBL:ENSG00000149922 TBX6
HGNC:11605 TBX6
Monarch:6911 TBX6
NCBI Gene:6911 TBX6
OMIM:602427 TBX6
UCSC:O95947 TBX6
Reference Transcript
RefSeq:XM_005255523.2 TBX6
RefSeq:NM_004608.3 TBX6
RefSeq:XM_011545926.2 TBX6
RefSeq:XM_017023614.1 TBX6
Other Identifiers
11721356_s_at
11731299_at
11731300_x_at
16825623
207684_3p_at
207684_PM_at
207684_at
215122_3p_at
215122_PM_at
215122_at
31602_at
3687436
3687437
3687438
3687439
3687441
3687442
3687443
3687444
3687445
3687446
3687447
3687448
3687449
3687450
3687451
3687453
3687454
3687455
63369_at
6911
8000779
A_23_P206568
A_24_P167970
GE489065
GO:0000122
GO:0000785
GO:0000978
GO:0000981
GO:0001570
GO:0001707
GO:0001708
GO:0001947
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0006355
GO:0006357
GO:0007498
GO:0007501
GO:0009653
GO:0010977
GO:0014043
GO:0023019
GO:0030154
GO:0032525
GO:0043226
GO:0043433
GO:0045893
GO:0045944
GO:0048856
GO:0061629
GO:0140110
GO:1990837
HMNXSV003018680
HMNXSV003032368
HMNXSV003052384
Hs.198301.1.S1_3p_x_at
ILMN_1679958
ILMN_1692095
ILMN_1763333
ILMN_1791147
PH_hs_0011682
TC16001018.hg
g13477108_3p_at
g13477108_3p_x_at
g4759213_3p_at
g4759213_3p_x_at
Participates
as an input of
LEF1:CTNNB1, NICD1 (NOTCH1) and TBX6 bind the HES7 gene in presomitic mesoderm (Homo sapiens)
TBX6 binds the MESP2 gene (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
TBX6 and LEF1:CTNNB1 bind the DLL1 gene (Homo sapiens)
TBX6 and LEF1:CTNNB1 bind the MSGN1 gene (Homo sapiens)
as a component of
HES7:LEF1:CTNNB1:TBX6:RBPJ:NICD1:HES7 gene [nucleoplasm] (Homo sapiens)
LEF1:CTNNB1:TBX6:RBPJ:NICD1:HES7 gene [nucleoplasm] (Homo sapiens)
TBX6:MESP2 gene [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
LEF1:CTNNB1:TBX6:DLL1 gene [nucleoplasm] (Homo sapiens)
CTNNB1:LEF1:TBX6:MSGN1 gene [nucleoplasm] (Homo sapiens)
as an output of
Expression of TBX6 in paraxial mesoderm (Homo sapiens)
This entity regulates
Negatively
Expression of SOX2 in posterior neural plate
(Homo sapiens)
Cross References
OpenTargets
ENSG00000149922
ENSEMBL
ENSP00000460425
,
ENST00000395224
,
ENSP00000279386
,
ENSP00000461223
,
ENST00000279386
,
ENSP00000378650
,
ENST00000553607
,
ENST00000567664
HPA
ENSG00000149922-TBX6
PRO
O95947
Pharos - Targets
O95947
GlyGen
O95947
Orphanet
TBX6
Interactors (35)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O94842 TOX4
0.781
7
UniProt:Q96LI6 HSFY1
0.781
7
UniProt:Q93062-3 RBPMS
0.666
4
UniProt:Q6P1W5 CA094
0.666
4
UniProt:Q16633 OBF1
0.556
3
UniProt:O43186 CRX
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q9Y5V3 MAGED1
1
MAGED1 [cytosol]
(R-HSA-196002)
0.556
3
UniProt:Q08117-2 TLE5
0.556
3
IntAct:EBI-16435576 CCSB ORF ID
0.556
3
UniProt:Q86WV8 Q86WV8
0.556
3
UniProt:O15496 PLA2G10
1
PLA2G10 [extracellular region]
(R-HSA-1498793)
0.556
3
UniProt:Q93062 RBPMS
0.556
3
UniProt:O60806 TBX19
0.556
3
UniProt:Q8N6F8 MET27
0.556
3
UniProt:P31930 UQCRC1
1
UQCRC1 [mitochondrial inner membrane]
(R-HSA-164284)
0.556
3
UniProt:P86480 PR20D
0.556
3
IntAct:EBI-22320186 CCSB ORF ID
0.556
3
UniProt:Q9NUJ3 T11L1
0.556
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:P13473-2 P134732
0.556
3
UniProt:Q15038 DAZP2
0.556
3
IntAct:EBI-22616457 CCSB ORF ID
0.556
5
UniProt:Q5TA45 CPSF3L
1
CPSF3L [nucleoplasm]
(R-HSA-6807411)
0.556
3
UniProt:Q96G42 KLD7B
0.556
3
UniProt:Q70EL1-9 USP54
0.556
3
UniProt:Q96SF7 TBX15
0.556
3
UniProt:P78424 PO6F2
0.556
3
UniProt:Q5BKX5-3 ACTMAP
0.556
3
UniProt:Q96A09 TET5B
0.556
3
UniProt:Q5SWW7 CJ055
0.556
3
IntAct:EBI-22384931 CCSB ORF ID
0.556
3
UniProt:Q8IUC1 KRTAP11-1
1
KRTAP11-1 [cytosol]
(R-HSA-6810294)
0.556
3
UniProt:Q3LI67 KRTAP6-3
1
KRTAP6-3 [cytosol]
(R-HSA-6810281)
0.556
3
UniProt:Q3LI66 KRTAP6-2
1
KRTAP6-2 [cytosol]
(R-HSA-6810261)
0.556
5
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