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TBX6 and LEF1:CTNNB1 bind the DLL1 gene
Stable Identifier
R-HSA-9793887
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
TBX6 and LEF1:CTNNB1 bind the DLL1 gene (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
LEF1 and CTNNB1 (beta-catenin) activated by WNT signaling bind the 5' region of the DLL1 gene (inferred from mouse homologs). TBX6 activated by NOTCH, WNT, and FGF signaling also binds a paraxial mesoderm enhancer in the DLL1 gene (inferred from mouse homologs).
Participants
Input
DLL1 gene [nucleoplasm]
(Homo sapiens)
LEF1:CTNNB1 [nucleoplasm]
(Homo sapiens)
TBX6 [nucleoplasm]
(Homo sapiens)
Output
LEF1:CTNNB1:TBX6:DLL1 gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Formation of paraxial mesoderm (Homo sapiens)
Inferred From
Tbx6 and Lef1:Ctnnb1 bind the Dll1 gene (Mus musculus)
Authored
May, B (2022-06-19)
Reviewed
Chalamalasetty, RB (2022-11-09)
Yamaguchi, TP (2022-11-09)
Created
May, B (2022-06-24)
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