Expression of TBX6 in paraxial mesoderm

Stable Identifier
R-HSA-9793383
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of TBX6 in paraxial mesoderm
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TBX6 is expressed in the primitive streak and then continues in the paraxial mesoderm (Xi et al. 2017 and inferred from the mouse homolog). NOTCH signaling acting through RBPJ directly activates expression of TBX6 in paraxial mesoderm (inferred from mouse homologs). WNT signaling and FGF signaling also directly or indirectly activate expression of TBX6 in paraxial mesoderm (inferred from mouse homologs). TBXT is not required for initial activation of TBX6 expression, but is required for maintenance of TBX6 expression (inferred from mouse homologs). Mesogenin1 (MSGN1), which is itself activated by TBX6, activates TBX6 in a reinforcing loop (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
28178531 In Vivo Human Somitogenesis Guides Somite Development from hPSCs

Liebscher, S, Xi, H, Schenke-Layland, K, Gonzalez, K, Fujiwara, W, Pyle, AD, Van Handel, B, Jan, M

Cell Rep 2017
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FGFR1 [plasma membrane] (Homo sapiens)
Regulator
NOTCH1 coactivator complex:TBX6 gene [nucleoplasm] (Homo sapiens)
Active Unit
RBPJ [nucleoplasm]
Regulator
MSGN1:TBX6 gene [nucleoplasm] (Homo sapiens)
Active Unit
MSGN1 [nucleoplasm]
Regulator
WNT3A [extracellular region] (Homo sapiens)
Regulator
TBXT [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Tbx6 in paraxial mesoderm (Mus musculus)
Authored
May, B  (2022-06-10)
Reviewed
Chalamalasetty, RB  (2022-11-09)
Yamaguchi, TP  (2022-11-09)
Created
May, B  (2022-06-12)
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