Reactome | Dlg4 [endocytic vesicle membrane]

Dlg4 [endocytic vesicle membrane]

Stable Identifier

R-RNO-416847

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

endocytic vesicle membrane

Synonyms

DLG4, P31016

Locations in the PathwayBrowser

Expand all

Neuronal System (Rattus norvegicus)

- Transmission across Chemical Synapses (Rattus norvegicus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Rattus norvegicus)
      - Trafficking of AMPA receptors (Rattus norvegicus)
        
        Trafficking of GluR1-containing AMPA receptors (Rattus norvegicus)
        
        TARP-PSD95-Mdm2 [endocytic vesicle membrane] (Rattus norvegicus)
        
        Dlg4 [endocytic vesicle membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P31016 Dlg4

Gene Names

Dlg4, Dlgh4, Psd95

Chain

chain:1-724

Reference Genes

BioGPS Gene:29495 Dlg4

KEGG:rno:29495 Dlg4

Monarch:29495 Dlg4

NCBI Gene:29495 Dlg4

UCSC:P31016 Dlg4

Reference Transcript

RefSeq:NM_019621.1 Dlg4

Participates

as a component of

TARP-PSD95-Mdm2 [endocytic vesicle membrane] (Rattus norvegicus)

Other forms of this molecule

Dlg4 [plasma membrane]

Dlg4 [cytosol]

Inferred From

DLG4 [endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_062567.1

PRO

P31016

RGD

68424

PDB

1RGR, 5HDY, 7CQF, 5YPO, 5YPR, 1QLC, 1IU2, 1IU0, 5D13, 1JXO, 5HEB, 1BFE, 3GSL, 5HED, 1TP3, 5W72, 5MZ7, 7F7G, 5HF1, 2MHO, 5HF4, 7F7I, 2XKX, 2KA9, 5HET, 5B64, 3WP0, 5HFC, 5HFD, 3WP1, 1TQ3, 1KJW, 1TP5, 1BE9, 5HFB, 5HEY, 5HFE, 1JXM, 5HFF, 5GNV

Interactors (43)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q00960 Grin2b	7	GRIN2B [plasma membrane] (R-RNO-419558) Grin2b [plasma membrane] (R-RNO-6794241) GRIN2B [endoplasmic reticulum membrane] (R-RNO-9609765) Grin2b [endoplasmic reticulum membrane] (R-RNO-9609846) p-Y-Grin2b [plasma membrane] (R-RNO-9628248) p-Y1472-Grin2b [plasma membrane] (R-RNO-9032617) phospho-p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane] (R-RNO-3928477)	0.915	11
UniProt:P97836 Dlgap1	2	Gkap1 [plasma membrane] (R-RNO-6794237) Dlgap1 [plasma membrane] (R-RNO-6794239)	0.843	9
UniProt:Q00959 Grin2a	3	Grin2a [plasma membrane] (R-RNO-6794271) Grin2a [endoplasmic reticulum membrane] (R-RNO-9609845) p-Y-Grin2a [plasma membrane] (R-RNO-9628245)	0.791	8
UniProt:P34926 MAP1A			0.784	16
UniProt:P35439 Grin1	2	Grin1 [plasma membrane] (R-RNO-9610826) Grin1 [endoplasmic reticulum membrane] (R-RNO-9609841)	0.708	4
UniProt:P22459 KCNA4	1	KCNA4 [plasma membrane] (R-HSA-977474)	0.676	3
UniProt:P19490 Gria1	7	GRIA1 [plasma membrane] (R-RNO-3004495) GRIA1 [endocytic vesicle membrane] (R-RNO-3004479) Gria1 [plasma membrane] (R-RNO-9620440) p-S849-Gria1 [plasma membrane] (R-RNO-9620442) GRIA1 [endoplasmic reticulum membrane] (R-RNO-5689460) GRIA1 [ER to Golgi transport vesicle membrane] (R-RNO-5689810) GRIA1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-RNO-5689811)	0.649	5
UniProt:P05480 Src	13	SRC-2 [cytosol] (R-MMU-191648) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-MMU-1810408) SRC-1 [plasma membrane] (R-MMU-65043) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-MMU-377598) phospho-p-Y419-SRC [cytosol] (R-MMU-377592) Src [cytosol] (R-MMU-418782) phospho-p-Y419-SRC-1 [plasma membrane] (R-MMU-112331) MyrG-SRC [plasma membrane] (R-MMU-8876922) phospho-p-Y419-SRC [cytosol] (R-MMU-8964276) SRC [cytosol] (R-MMU-9628701) MyrG-p-Y424-Src [plasma membrane] (R-MMU-9011258) Activated Src [nucleoplasm] (R-MMU-8937700) p-Y416-Src [cytosol] (R-MMU-8964306)	0.645	9
UniProt:P08588 ADRB1	1	ADRB1 [plasma membrane] (R-HSA-390653)	0.623	2
UniProt:O54857 PTEN			0.612	5
UniProt:P28572-2 SLC6A9			0.602	4
UniProt:Q9WVI4 Gucy1a2	2	Guanylate cyclase soluble subunit alpha-2 [cytosol] (R-RNO-427260) Gucy1a2 [cytosol] (R-RNO-391996)	0.602	7
UniProt:Q9Z252 Lin7b	1	Lin7b [plasma membrane] (R-RNO-6794272)	0.599	6
UniProt:Q91ZD4 Vangl2	2	pS5,S82,S84-Vangl2 [plasma membrane] (R-MMU-4551502) Vangl2 [plasma membrane] (R-MMU-4551496)	0.591	6
UniProt:Q12959-2 DLG1			0.591	9
UniProt:O08560	1	Dgkz [plasma membrane] (R-RNO-426060)	0.59	6
UniProt:Q71RJ2	2	Cacng2 [plasma membrane] (R-RNO-210375) Cacng2 [endocytic vesicle membrane] (R-RNO-416846)	0.589	2
UniProt:Q9WV48 Shank1	2	Shank1 [cytosol] (R-RNO-6794229) Shank1 [cytosol] (R-RNO-6794274)	0.564	3
UniProt:Q62696 Dlg1	4	Dlg1 [plasma membrane] (R-RNO-9617427) Dlg1 [endoplasmic reticulum membrane] (R-RNO-9610616) Dlg1 [cytosol] (R-RNO-416332) Dlg1 [plasma membrane] (R-RNO-375977)	0.564	3
UniProt:Q13224 GRIN2B	6	GRIN2B [plasma membrane] (R-HSA-419558) GRIN2B [endoplasmic reticulum membrane] (R-HSA-9609765) GRIN2B [transport vesicle membrane] (R-HSA-9610568) p-Y-GRIN2B [plasma membrane] (R-HSA-9612185) p-Y1474-GRIN2B [plasma membrane] (R-HSA-9032602) p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane] (R-HSA-3928477)	0.558	2
UniProt:Q12879 GRIN2A	3	GRIN2A [plasma membrane] (R-HSA-419556) GRIN2A [endoplasmic reticulum membrane] (R-HSA-9609760) p-Y-GRIN2A [plasma membrane] (R-HSA-9612190)	0.558	2
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189)	0.558	2
IntAct:EBI-16035555 CRIPT-1			0.558	2
UniProt:Q9P021 CRIPT			0.558	2
UniProt:P70587 Lrrc7	4	Lrrc7 [extracellular region] (R-RNO-6799681) Lrrc7 [specific granule lumen] (R-RNO-6799616) Lrrc7 [cytosol] (R-RNO-9611392) Lrrc7 [cytosol] (R-RNO-9611351)	0.556	5
UniProt:Q6IN36	1	Wipf1 [cytosol] (R-RNO-201874)	0.556	5
UniProt:Q9Z1T4	1	Cnksr2 [cytosol] (R-RNO-5672632)	0.556	4
UniProt:F1MAB7	1	Dgki [plasma membrane] (R-RNO-426064)	0.556	4
UniProt:P30937	1	Sstr4 [plasma membrane] (R-RNO-374745)	0.556	3
UniProt:Q00961 Grin2c	5	GRIN2C [plasma membrane] (R-RNO-419560) Grin2c [plasma membrane] (R-RNO-9614232) GRIN2C [endoplasmic reticulum membrane] (R-RNO-9609761) Grin2c [endoplasmic reticulum membrane] (R-RNO-9610096) p-Y-Grin2c [plasma membrane] (R-RNO-9628252)	0.553	2
UniProt:P70478	6	Apc [nucleoplasm] (R-RNO-3361755) phospho-Apc [cytosol] (R-RNO-3009421) Apc [cytosol] (R-RNO-5246690) Apc [cytosol] (R-RNO-2976014) Apc [cytosol] (R-RNO-2976013) Apc [cytosol] (R-RNO-2976015)	0.544	2
UniProt:Q80Z96	1	Vangl1 [plasma membrane] (R-MMU-9714275)	0.544	4
UniProt:P97837	1	Dlgap2 [plasma membrane] (R-RNO-6794266)	0.527	2
UniProt:Q62765-1 NLGN1			0.527	2
UniProt:P20595 Gucy1b3	1	Guanylate cyclase soluble subunit beta-1 [cytosol] (R-RNO-427265)	0.524	2
UniProt:P28572	1	Slc6a9 [plasma membrane] (R-RNO-444127)	0.524	2
UniProt:Q8R4T5 GRASP			0.524	3
UniProt:P10608	5	phospho-Adrb2 [clathrin-coated endocytic vesicle membrane] (R-RNO-8869143) Adrb2 [endosome membrane] (R-RNO-6783036) Adrb2 [endosome membrane] (R-RNO-6783066) phospho-Adrb2 [plasma membrane] (R-RNO-8852158) Adrb2 [plasma membrane] (R-RNO-390647)	0.499	2
UniProt:Q5XIE8 ITM2B			0.499	5
UniProt:Q460M5	1	Lrfn2 [plasma membrane] (R-RNO-197665)	0.463	3
UniProt:Q8VHW5	2	Cacng8 [plasma membrane] (R-RNO-210486) Cacng8 [endocytic vesicle membrane] (R-RNO-416848)	0.463	2
UniProt:Q9EQL9 Sharpin	1	Sharpin [cytosol] (R-RNO-6794270)	0.463	2
UniProt:Q9JJ40 NHRF3			0.463	2

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