Translation of Accessory Proteins

Stable Identifier
R-HSA-9727281
Type
Pathway
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, cytosol
ReviewStatus
5/5
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Translation of Accessory Proteins
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Accessory proteins are encoded after the polymerase/replicase genes by mRNA6 (protein 6), mRNA7 (protein 7a), mRNA8 (protein 8), and bicistronic mRNA9b (protein 9b). These proteins are not essential for viral replication and assembly in vitro, but likely influence the pathogenesis of the SARS-CoV-2, like the accessory ORFs of other coronaviruses (Frieman et al, 2006; Narayanan et al, 2008).
Literature References
PubMed ID Title Journal Year
18045721 SARS coronavirus accessory proteins

Narayanan, K, Huang, C, Makino, S

Virus Res 2008
17037522 SARS coronavirus accessory ORFs encode luxury functions

Frieman, MB, Yount, B, Sims, AC, Deming, DJ, Morrison, TE, Sparks, J, Denison, M, Heise, M, Baric, RS

Adv Exp Med Biol 2006
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
viral translation (0019081)
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2021-04-13)
Reviewed
Gillespie, ME  (2022-05-10)
Created
Stephan, R  (2021-04-15)
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