9b homodimer localizes to the mitochondrial outer membrane

Stable Identifier
R-HSA-9727300
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol, mitochondrial outer membrane
ReviewStatus
5/5
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9b homodimer localizes to the mitochondrial outer membrane
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SARS-CoV-2 protein 9b localizes to the membrane of mitochondria where it suppresses IFN-I responses (Jiang et al, 2020).
Literature References
PubMed ID Title Journal Year
32728199 SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70

Jiang, HW, Zhang, HN, Meng, QF, Xie, J, Li, Y, Chen, H, Zheng, YX, Wang, XN, Qi, H, Zhang, J, Wang, PH, Han, ZG, Tao, SC

Cell Mol Immunol 2020
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2021-04-13)
Reviewed
Gillespie, ME  (2022-05-10)
Created
Stephan, R  (2021-04-15)
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