mRNA6 is translated to protein 6

Stable Identifier
R-HSA-9727292
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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mRNA6 is translated to protein 6
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SARS-Cov-2 mRNA6 open reading frame has a length of 186 nt and encodes the 61 aa protein 6 (Wu et al, 2020). Protein 6 has a membrane-embedded alpha-helix on its N-terminus and initially localizes to the ER and the membranes of autophagosomes and lysosomes, as shown in HEK 293 T cells (Lee et al, 2021).

Protein 6 of SARS-Cov-2 has been shown in HEK 293 T cells to localize within 160 nm of nuclear pore complexes present at the nuclear envelope and at annulate lamellae in the cytoplasm, where it binds to the Nup98-Rae1 complex (Miorin et al, 2020).
Literature References
PubMed ID Title Journal Year
33766124 Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor

Lee, JG, Huang, W, Lee, H, van de Leemput, J, Kane, MA, Han, Z

Cell Biosci 2021
32015508 A new coronavirus associated with human respiratory disease in China

Wu, F, Zhao, S, Yu, B, Chen, YM, Wang, W, Song, ZG, Hu, Y, Tao, ZW, Tian, JH, Pei, YY, Yuan, ML, Zhang, YL, Dai, FH, Liu, Y, Wang, QM, Zheng, JJ, Xu, L, Holmes, EC, Zhang, YZ

Nature 2020
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2021-04-13)
Reviewed
Gillespie, ME  (2022-05-10)
Created
Stephan, R  (2021-04-15)
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