Unknown kinase phosphorylates 9b

Stable Identifier
R-HSA-9758486
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
ReviewStatus
5/5
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Binding of SARS-CoV-2 ORF9b to TOMM70 prevents the recognition of native Hsp90 and chaperone-associated TOMM70 substrates, thus suppressing innate immunity. This binding is abolished by apparent phosphorylation of ORF9b at S53, possibly by host DMPK type kinases. In the B.1.1.7 UK variant ORF9b expression is highly enhanced, probably overwhelming host kinase activity (Brandherm et al, 2021; Krogan et al, 2021; Bouhaddou et al, 2020, suppl.).
Literature References
PubMed ID Title Journal Year
34127972 Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

Jura, N, Beltrao, P, García-Sastre, A, Shokat, K, Whelan, MVX, Bouhaddou, M, Reuschl, AK, Braberg, H, Thorne, LG, Zuliani-Alvarez, L, Noursadeghi, M, Jolly, C, Krogan, NJ, Fabius, JM, Obernier, K, Ummadi, M, Batra, J, Pelin, A, Towers, GJ, Swaney, DL, Jahun, A, Chen, KH, Soucheray, M, Hiatt, J, Goodfellow, IG, Turner, J, Rojc, A, Harjai, B, Memon, D, Polacco, B, Hosmillo, M, Verba, K, Richards, A

bioRxiv 2021
32645325 The Global Phosphorylation Landscape of SARS-CoV-2 Infection

Beltrao, P, Fischer, ER, Koh, C, Vignuzzi, M, Johnson, JR, Richards, AL, Bouhaddou, M, Melnyk, JE, Meyer, B, O'Neal, MC, Guo, JZ, Lim, JK, Shoichet, B, Dugourd, A, Hernandez-Armenta, C, Fabius, JM, McBride, T, Obernier, K, Kim, M, Leach, AR, Manners, EJ, Weigang, S, Moreno, E, Cakir, M, Soucheray, M, Cai, Y, Knerr, J, Hüttenhain, R, Patil, T, Polacco, BJ, Muralidharan, M, Hardy, A, Mathy, CJP, Nilsson-Payant, BE, Grosse, R, Quintero, D, Li, Q, Goff, M, Miorin, L, Stevenson, E, Swaney, DL, Tutuncuoglu, B, Mullins, RD, Shokat, KM, Rezelj, VV, Zhou, Y, Batra, J, Jang, G, Bouhaddou, S, Krogan, NJ, Tran, QD, Modak, M, tenOever, BR, White, KM, Dunham, A, de Wit, E, Robinot, R, Gaulton, A, Kochs, G, Xu, J, Saez-Rodriguez, J, Valdeolivas, A, García-Sastre, A, Félix, E, Vallet, T, Shi, Y, Memon, D, Gordon, DE, Broadhurst, DJ, Ulferts, S, Kaake, RM, Klippsten, S, Kortemme, T, Ott, M, Rojc, A, Chang, JCJ, Hiatt, J, Correa Marrero, M

Cell 2020
34502139 Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90

Pfaender, S, Brandherm, L, Brüggemann, Y, Kreimendahl, S, Klöhn, M, Rassow, J, Kobaš, AM

Int J Mol Sci 2021
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of unknown kinase [cytosol]

Authored
Reviewed
Created
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