6 localizes to the nuclear envelope

Stable Identifier
R-HSA-9727293
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane
ReviewStatus
5/5
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6 localizes to the nuclear envelope
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Protein 6 of SARS-Cov-2 has been shown in HEK 293 T cells to localize within 160 nm of nuclear pore complexes present at the nuclear envelope and at annulate lamellae in the cytoplasm, where it binds to the Nup98-Rae1 complex (Miorin et al, 2020).
Literature References
PubMed ID Title Journal Year
33097660 SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

Mena, I, Patel, RS, García-Sastre, A, Mei, M, Rosenberg, BR, Cupic, A, Makio, T, Martin-Sancho, L, Rathnasinghe, R, Sanchez-Aparicio, MT, Fontoura, BMA, Kehrer, T, Uccellini, M, Danziger, O, Chanda, SK, Schotsaert, M, White, KM, Krogan, NJ, Moreno, E, Yin, X, Miorin, L, Ren, Y, Zhang, K, Gao, S, Cohen, P, Aydillo, T, Wozniak, RW

Proc Natl Acad Sci U S A 2020
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2021-04-13)
Reviewed
Gillespie, ME  (2022-05-10)
Created
Stephan, R  (2021-04-15)
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