Reactome | HC-ABCG2 [plasma membrane]

HC-ABCG2 [plasma membrane]

Stable Identifier

R-HSA-917929

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ABCG2

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        NFE2L2 regulating MDR associated enzymes (Homo sapiens)
        
        NFE2L2 dependent ABCG2 expression (Homo sapiens)
        
        HC-ABCG2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UNQ0 ABCG2

Gene Names

ABCG2, ABCP, BCRP, BCRP1, MXR

Chain

chain:1-655

Reference Genes

BioGPS Gene:9429 ABCG2

COSMIC (genes):ABCG2 ABCG2

CTD Gene:9429 ABCG2

dbSNP Gene:9429 ABCG2

ENSEMBL:ENSG00000118777 ABCG2

HGNC:74 ABCG2

KEGG:hsa:9429 ABCG2

Monarch:9429 ABCG2

NCBI Gene:9429 ABCG2

OMIM:603756 ABCG2

UCSC:Q9UNQ0 ABCG2

Reference Transcript

Other Identifiers

11724537_a_at

11724538_a_at

16977868

209735_PM_at

209735_at

2777284

2777285

2777286

2777287

2777288

2777289

2777290

2777291

2777292

2777293

2777295

2777296

2777297

2777298

2777299

2777300

2777301

2777303

2777305

2777306

2777307

2777308

2777309

2777310

2777312

2777313

2777314

2777315

33733_at

8101675

9429

A_23_P18713

A_33_P3361067

GE575063

GE81445

GO:0003013

GO:0003014

GO:0003824

GO:0005215

GO:0005515

GO:0005524

GO:0005654

GO:0005739

GO:0005886

GO:0006629

GO:0006869

GO:0008514

GO:0008559

GO:0015143

GO:0015225

GO:0015562

GO:0015711

GO:0015747

GO:0015878

GO:0016020

GO:0016324

GO:0016787

GO:0016887

GO:0030148

GO:0031526

GO:0031966

GO:0032217

GO:0032218

GO:0042626

GO:0042802

GO:0042803

GO:0042910

GO:0043226

GO:0045121

GO:0046415

GO:0046624

GO:0046983

GO:0055085

GO:0070633

GO:0097744

GO:0098591

GO:0098754

GO:0140115

GO:0140359

GO:0140657

GO:0150104

GO:1990748

GO:1990962

HMNXSV003049042

ILMN_1789641

PH_hs_0011514

TC04001370.hg

TC04002625.hg

g12414050_3p_at

Participates

as a protein marker of

keratinocyte stem cell of skin epidermis basal layer (Homo sapiens)

as an output of

NFE2L2 dependent ABCG2 expression (Homo sapiens)

as a member of

ABCC1,ABCG2 [plasma membrane] (Homo sapiens)

as a component of

Other forms of this molecule

HC-ABCG2 [apical plasma membrane]

Inferred To

abcG8 [plasma membrane] (Dictyostelium discoideum)

CG18633 [plasma membrane] (Drosophila melanogaster)

abcg2 [plasma membrane] (Xenopus tropicalis)

abcG22 [plasma membrane] (Dictyostelium discoideum)

ABCG2 [plasma membrane] (Bos taurus)

ABCG2 [plasma membrane] (Sus scrofa)

abcG4 [plasma membrane] (Dictyostelium discoideum)

abcG12 [plasma membrane] (Dictyostelium discoideum)

bw [plasma membrane] (Drosophila melanogaster)

wht-5 [plasma membrane] (Caenorhabditis elegans)

ABCG2A [plasma membrane] (Sus scrofa)

abcG24 [plasma membrane] (Dictyostelium discoideum)

abcG7 [plasma membrane] (Dictyostelium discoideum)

Abcg2 [plasma membrane] (Canis familiaris)

Abcg2 [plasma membrane] (Mus musculus)

Abcg2 [plasma membrane] (Rattus norvegicus)

abcx-1 [plasma membrane] (Caenorhabditis elegans)

HC-ABCG2 [plasma membrane] (Plasmodium falciparum)

ADP1 [plasma membrane] (Saccharomyces cerevisiae)

Homologues of HC-ABCG2 [plasma membrane] (Caenorhabditis elegans)

Homologues of HC-ABCG2 [plasma membrane] (Dictyostelium discoideum)

Homologues of HC-ABCG2 [plasma membrane] (Drosophila melanogaster)

Homologues of HC-ABCG2 [plasma membrane] (Sus scrofa)

Modified Residues

Name

L-cystine (cross-link) at 603

Coordinate

603

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Cross References

RefSeq

NP_001244315.1, NP_001335917.1, NP_001335915.1, NP_001335918.1, NP_001335914.1, XP_005263412.1, XP_054207259.1, NP_004818.2, XP_011530722.1

ZINC - World Drugs

ABCG2_HUMAN

Guide to Pharmacology - Targets

792

OpenTargets

ENSG00000118777

ENSEMBL

ENST00000237612, ENST00000515655, ENSP00000498246, ENSP00000237612, ENST00000650821, ENSP00000426917, ENSG00000118777

ZINC - FDA approved

ABCG2_HUMAN

ZINC - Substances

ABCG2_HUMAN

ZINC - Biogenic

ABCG2_HUMAN

ZINC target

Q9UNQ0

PRO

Q9UNQ0

GlyGen

Q9UNQ0

PDB

8P7W, 8BHT, 6FEQ, 8QCM, 7OJI, 7NFD, 5NJG, 6HCO, 6VXH, 6VXI, 8PY4, 6ETI, 8PXO, 6HZM, 6VXF, 8BI0, 6VXJ, 8Q7B, 6FFC, 7NEQ, 5NJ3, 8P8J, 8P8A, 6HIJ, 7NEZ, 8U2C, 7OJ8, 6HBU, 7OJH

ZINC - Investigational

ABCG2_HUMAN

ZINC - Metabolites

ABCG2_HUMAN

HPA

ENSG00000118777-ABCG2

GeneCards

ABCG2

Pharos - Targets

Q9UNQ0

ZINC - Predictions - Purchasable

ABCG2_HUMAN

HMDB Protein

HMDBP02257

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UNQ0 ABCG2	2	HC-ABCG2 [plasma membrane] (R-HSA-917929) HC-ABCG2 [apical plasma membrane] (R-HSA-9794401)	0.791	5
UniProt:P11309-2 PIM1			0.639	5
UniProt:P22413 ENPP1	1	ENPP1 [plasma membrane] (R-HSA-196973)	0.602	4