Regulation of BACH1 activity

Stable Identifier
R-HSA-9708530
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Regulation of BACH1 activity
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The transcription factor BTB and CNC homology 1 (BACH1) is widely expressed in most mammalian tissues and functions primarily as a transcriptional suppressor by heterodimerizing with small Maf proteins and binding to Maf recognition elements in the promoters of targeted genes. It has a key regulatory role in the production of reactive oxygen species (ROS), cell cycle, heme homeostasis, hematopoiesis, and immunity and has been shown to suppress ischemic angiogenesis and promote breast cancer metastasis (Zhang et al, 2018; Okada et al, 2010).
Literature References
PubMed ID Title Journal Year
20501657 Bach1-dependent and -independent regulation of heme oxygenase-1 in keratinocytes

Ikawa, S, Ogawa, E, Muto, A, Okada, S, Aiba, S, Igarashi, K, Katoh, Y, Nakanome, A, Okuyama, R

J Biol Chem 2010
30370001 Bach1: Function, Regulation, and Involvement in Disease

Jia, M, Li, Q, Meng, D, Wei, X, Niu, C, Zhang, X, Guo, J

Oxid Med Cell Longev 2018
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Event Information
Go Biological Process
regulation of DNA-binding transcription factor activity (0051090)
Orthologous Events
Regulation of BACH1 activity (Bos taurus)
Regulation of BACH1 activity (Canis familiaris)
Regulation of BACH1 activity (Drosophila melanogaster)
Regulation of BACH1 activity (Gallus gallus)
Regulation of BACH1 activity (Mus musculus)
Regulation of BACH1 activity (Rattus norvegicus)
Regulation of BACH1 activity (Sus scrofa)
Regulation of BACH1 activity (Xenopus tropicalis)
Authored
Stephan, R  (2020-11-19)
Reviewed
Somers, J  (2021-01-23)
Created
Stephan, R  (2020-11-30)
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