Regulation of BACH1 activity

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R-HSA-9708530
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Pathway
Species
Homo sapiens
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The transcription factor BTB and CNC homology 1 (BACH1) is widely expressed in most mammalian tissues and functions primarily as a transcriptional suppressor by heterodimerizing with small Maf proteins and binding to Maf recognition elements in the promoters of targeted genes. It has a key regulatory role in the production of reactive oxygen species (ROS), cell cycle, heme homeostasis, hematopoiesis, and immunity and has been shown to suppress ischemic angiogenesis and promote breast cancer metastasis (Zhang et al, 2018; Okada et al, 2010).

Literature References
PubMed ID Title Journal Year
30370001 Bach1: Function, Regulation, and Involvement in Disease

Zhang, X, Guo, J, Wei, X, Niu, C, Jia, M, Li, Q, Meng, D

Oxid Med Cell Longev 2018
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