FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))

Stable Identifier
R-HSA-9708517
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
BACH1 gets ubiquitinated
ReviewStatus
5/5
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FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))
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The leucine-rich repeat family of F-box proteins (FBXLs) function as adapter for the SKP1-CUL1-F-box protein (SCF) E3 ubiquitin ligase. FBXL17 is a regulator of the nuclear factor erythroid 2-related factor 2 (NFE2L2) oxidative stress pathway. By binding to the transcriptional repressor/regulator protein BACH1 it controls the transcription of the NFE2L2 target heme oxygenase 1 (HMOX1) via turnover of BACH1 in the absence or presence of extrinsic oxidative stress (Tan et al, 2013).
Literature References
PubMed ID Title Journal Year
24035498 Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover

Tan, MK, Lim, HJ, Bennett, EJ, Shi, Y, Harper, JW

Mol. Cell 2013
Participants
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Output
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as an event of
Catalyst Activity

ubiquitin protein ligase activity of BACH1:FBXL17:SCF (SKP2) [nucleoplasm]

Physical Entity
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Bos taurus)
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Mus musculus)
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Sus scrofa)
Authored
Stephan, R  (2020-11-23)
Reviewed
Somers, J  (2021-01-23)
Created
Stephan, R  (2020-11-30)
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