Reactome | FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))

FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))

Stable Identifier

R-HSA-9708517

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

BACH1 gets ubiquitinated

ReviewStatus

5/5

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FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))

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The leucine-rich repeat family of F-box proteins (FBXLs) function as adapter for the SKP1-CUL1-F-box protein (SCF) E3 ubiquitin ligase. FBXL17 is a regulator of the nuclear factor erythroid 2-related factor 2 (NFE2L2) oxidative stress pathway. By binding to the transcriptional repressor/regulator protein BACH1 it controls the transcription of the NFE2L2 target heme oxygenase 1 (HMOX1) via turnover of BACH1 in the absence or presence of extrinsic oxidative stress (Tan et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
24035498	Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover Bennett, EJ, Lim, HJ, Shi, Y, Tan, MK, Harper, JW	Mol. Cell	2013