FBXL17 binds BACH1

Stable Identifier
R-HSA-9708557
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
FBXL17 acts on BACH1:MAFK, binding to BACH1
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The leucine-rich repeat family of F-box proteins (FBXLs) function as adapter for the SKP1-CUL1-F-box protein (SCF) E3 ubiqitin ligase. FBXL17 is a regulator of the nuclear factor erythroid 2-related factor 2 (NFE2L2) oxidative stress pathway. By binding to the transcriptional repressor transcription regulator protein BACH1 it controls the transcription of the NFE2L2 target heme oxygenase 1 (HMOX1) via turnover of BACH1 in the absence or presence of extrinsic oxidative stress (Tan et al, 2013).

Literature References
PubMed ID Title Journal Year
24035498 Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover

Tan, MK, Lim, HJ, Bennett, EJ, Shi, Y, Harper, JW

Mol. Cell 2013
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