BACH1:FBXL17 binds SCF(SKP2) complex

Stable Identifier
R-HSA-9708525
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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BACH1:FBXL17 binds SCF(SKP2) complex
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The leucine-rich repeat family of F-box proteins (FBXLs) function as adapter for the SKP1-CUL1-F-box protein (SCF) E3 ubiquitin ligase. FBXL17 is a regulator of the nuclear factor erythroid 2-related factor 2 (NFE2L2) oxidative stress pathway. By binding to the transcriptional repressor/regulator protein BACH1 it controls the transcription of the NFE2L2 target heme oxygenase 1 (HMOX1) via turnover of BACH1 in the absence or presence of extrinsic oxidative stress (Tan et al, 2013).
Literature References
PubMed ID Title Journal Year
24035498 Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover

Bennett, EJ, Lim, HJ, Shi, Y, Tan, MK, Harper, JW

Mol. Cell 2013
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Orthologous Events
BACH1:FBXL17 binds SCF(SKP2) complex (Bos taurus)
BACH1:FBXL17 binds SCF(SKP2) complex (Drosophila melanogaster)
BACH1:FBXL17 binds SCF(SKP2) complex (Gallus gallus)
BACH1:FBXL17 binds SCF(SKP2) complex (Mus musculus)
BACH1:FBXL17 binds SCF(SKP2) complex (Sus scrofa)
Authored
Stephan, R  (2020-11-23)
Reviewed
Somers, J  (2021-01-23)
Created
Stephan, R  (2020-11-30)
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