p-Y483 BACH1 translocates from the nucleoplasm to the cytosol

Stable Identifier
R-HSA-9708466
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
Synonyms
BACH1 gets shuttled out of the nucleus
ReviewStatus
5/5
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p-Y483 BACH1 translocates from the nucleoplasm to the cytosol
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Transcription regulator protein BACH1, the negative regulator of nuclear factor erythroid 2-related factor 2 (NFE2L2), competes with NFE2L2 for binding to antioxidant response elements (ARE). Redox regulation of BACH1 is an alternative mechanism to induce multiple ARE-governed genes. BACH1 exits the nucleus within 1–2 h upon antioxidant treatment, mediated via tyrosine-483 phosphorylation by an unknown kinase (Ishikawa et al, 2005; Kaspar and Jaiswal, 2010).
Literature References
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Input
Output
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as an event of
This event is regulated
Positively by
Regulator
ROS [nucleoplasm]
Orthologous Events
p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Bos taurus)
p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Canis familiaris)
p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Drosophila melanogaster)
p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Gallus gallus)
p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Mus musculus)
p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Rattus norvegicus)
p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Sus scrofa)
p-Y483 BACH1 translocates from the nucleoplasm to the cytosol (Xenopus tropicalis)
Authored
Stephan, R  (2020-11-23)
Reviewed
Somers, J  (2021-01-23)
Created
Stephan, R  (2020-11-30)
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