Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-11Y PDGFRA V561D [plasma membrane]
Stable Identifier
R-HSA-9672025
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Alpha platelet-derived growth factor receptor, PGDS_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by PDGFR in disease (Homo sapiens)
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants (Homo sapiens)
Autophosphorylation of PDGFR mutant dimers (Homo sapiens)
p-11Y PDGFR mutant receptor dimers [plasma membrane] (Homo sapiens)
p-11Y juxtamembrane domain mutant PDGFRA dimers of PDGFRA [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D dimer [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D [plasma membrane] (Homo sapiens)
GRB2:SOS1 complex binds to mutant PDGFR receptor (Homo sapiens)
p-11Y PDGFR mutant receptor dimers [plasma membrane] (Homo sapiens)
p-11Y juxtamembrane domain mutant PDGFRA dimers of PDGFRA [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D dimer [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D [plasma membrane] (Homo sapiens)
p-11Y PDGFR mutatnt receptors:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-11Y PDGFR mutant receptor dimers [plasma membrane] (Homo sapiens)
p-11Y juxtamembrane domain mutant PDGFRA dimers of PDGFRA [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D dimer [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D [plasma membrane] (Homo sapiens)
PI3-kinase binds to mutant PDGFR receptor (Homo sapiens)
p-11Y PDGFR mutant dimers:PI3K [plasma membrane] (Homo sapiens)
p-11Y PDGFR mutant receptor dimers [plasma membrane] (Homo sapiens)
p-11Y juxtamembrane domain mutant PDGFRA dimers of PDGFRA [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D dimer [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D [plasma membrane] (Homo sapiens)
p-11Y PDGFR mutant receptor dimers [plasma membrane] (Homo sapiens)
p-11Y juxtamembrane domain mutant PDGFRA dimers of PDGFRA [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D dimer [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D [plasma membrane] (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of mutant PDGFR (Homo sapiens)
p-11Y PDGFR mutant dimers:PI3K [plasma membrane] (Homo sapiens)
p-11Y PDGFR mutant receptor dimers [plasma membrane] (Homo sapiens)
p-11Y juxtamembrane domain mutant PDGFRA dimers of PDGFRA [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D dimer [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D [plasma membrane] (Homo sapiens)
SOS-mediated nucleotide exchange of RAS downstream of mutant PDGFR receptors (Homo sapiens)
p-11Y PDGFR mutatnt receptors:GRB2:SOS1 [plasma membrane] (Homo sapiens)
p-11Y PDGFR mutant receptor dimers [plasma membrane] (Homo sapiens)
p-11Y juxtamembrane domain mutant PDGFRA dimers of PDGFRA [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D dimer [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D [plasma membrane] (Homo sapiens)
STAT binds to the mutant PDGFRA receptor (Homo sapiens)
p-11Y PDGFR mutant receptor dimers [plasma membrane] (Homo sapiens)
p-11Y juxtamembrane domain mutant PDGFRA dimers of PDGFRA [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D dimer [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D [plasma membrane] (Homo sapiens)
p-11Y PDGFRA mutant receptor dimer:STAT [plasma membrane] (Homo sapiens)
p-11Y PDGFR mutant receptor dimers [plasma membrane] (Homo sapiens)
p-11Y juxtamembrane domain mutant PDGFRA dimers of PDGFRA [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D dimer [plasma membrane] (Homo sapiens)
p-11Y PDGFRA V561D [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16234 PDGFRA
Gene Names
PDGFRA, PDGFR2, RHEPDGFRA
Chain
signal peptide:1-23, chain:24-1089
Reference Genes
BioGPS Gene:5156 PDGFRA
COSMIC (genes):PDGFRA PDGFRA
CTD Gene:5156 PDGFRA
dbSNP Gene:5156 PDGFRA
ENSEMBL:ENSG00000134853 PDGFRA
ENSEMBL_homo_sapiens_GENE:ENSG00000134853.12 PDGFRA
HGNC:8803 PDGFRA
KEGG Gene (Homo sapiens):5156 PDGFRA
Monarch:5156 PDGFRA
NCBI Gene:5156 PDGFRA
OMIM:173490 PDGFRA
UCSC:P16234 PDGFRA
Reference Transcript
RefSeq:XM_005265743.1 PDGFRA
RefSeq:NM_006206.5 PDGFRA
RefSeq:NM_001347829.1 PDGFRA
Other Identifiers
11743850_at
11750772_a_at
11760753_a_at
11762023_at
1554828_PM_at
1554828_at
16966809
1731_at
1968_g_at
1987_at
203131_PM_at
203131_at
215305_PM_at
215305_at
2727350
2727370
2727372
2727373
2727374
2727375
2727376
2727377
2727378
2727380
2727381
2727382
2727383
2727386
2727387
2727388
2727389
2727391
2727393
2727395
2727396
2727397
2727398
2727401
2727402
2727403
2727404
2727406
2727407
2727408
2727411
2727413
2727414
2727415
5156
8095080
84284_at
A_14_P111616
A_14_P125923
A_23_P300033
A_23_P332536
GE57864
GO:0000166
GO:0001553
GO:0001701
GO:0001775
GO:0002244
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005018
GO:0005021
GO:0005161
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0005902
GO:0005929
GO:0006468
GO:0006629
GO:0006935
GO:0007010
GO:0007155
GO:0007169
GO:0008210
GO:0008284
GO:0008585
GO:0009653
GO:0009887
GO:0009897
GO:0009986
GO:0010544
GO:0010863
GO:0016020
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0018108
GO:0022414
GO:0023019
GO:0023052
GO:0030054
GO:0030154
GO:0030198
GO:0030324
GO:0030325
GO:0030335
GO:0030539
GO:0032956
GO:0032991
GO:0033327
GO:0034614
GO:0035790
GO:0036211
GO:0038085
GO:0038091
GO:0042060
GO:0042475
GO:0042803
GO:0042995
GO:0043226
GO:0043235
GO:0044877
GO:0046777
GO:0048008
GO:0048146
GO:0048407
GO:0048557
GO:0048584
GO:0048701
GO:0048704
GO:0048705
GO:0048856
GO:0048870
GO:0050850
GO:0050872
GO:0050921
GO:0051897
GO:0055003
GO:0060021
GO:0060089
GO:0060325
GO:0060326
GO:0061298
GO:0070374
GO:0070527
GO:0071230
GO:0071363
GO:0072277
GO:0140096
GO:2000739
HMNXSV003051985
HMNXSV003054613
Hs.166074.0.S1_3p_at
Hs2.74615.2.A1_3p_at
Hs2.74615.2.A1_3p_s_at
ILMN_1681949
ILMN_2086470
M21574_at
PH_hs_0004257
TC04002931.hg
g5453869_3p_at
Participates
as a component of
p-11Y PDGFRA V561D dimer [plasma membrane] (Homo sapiens)
Other forms of this molecule
PDGFRA L629P [plasma membrane]
PDGFRA N659K [plasma membrane]
PDGFRA T674I [plasma membrane]
PDGFRA S601P [plasma membrane]
PDGFRA Y288C [endoplasmic reticulum membrane]
PDGFRA Y375_K455del [endoplasmic reticulum membrane]
p-11Y PDGFRA Y288C [endoplasmic reticulum membrane]
p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane]
PDGFRA D842_M844del [plasma membrane]
PDGFRA D842Y [plasma membrane]
PDGFRA D842V [plasma membrane]
PDGFRA I843_D846del [plasma membrane]
PDGFRA D842_H845del [plasma membrane]
PDGFRA D842del [plasma membrane]
PDGFRA D842_I843delinsV [plasma membrane]
PDGFRA D846Y [plasma membrane]
PDGFRA D843_845del [plasma membrane]
PDGFRA D842_D846del [plasma membrane]
PDGFRA N848K [plasma membrane]
PDGFRA Y849C [plasma membrane]
PDGFRA D843_844del [plasma membrane]
PDGFRA D846V [plasma membrane]
PDGFRA D842L [plasma membrane]
PDGFRA V561D [plasma membrane]
PDGFRA V561A [plasma membrane]
PDGFRA V536E [plasma membrane]
PDGFRA V536M [plasma membrane]
p-11Y PDGFRA D842V [plasma membrane]
p-11Y PDGFRA D846Y [plasma membrane]
p-11Y PDGFRA D842del [plasma membrane]
p-11Y PDGFRA D843_844del [plasma membrane]
p-11Y-PDGFRA D842_I843delinsV [plasma membrane]
p-11Y PDGFRA D843_846del [plasma membrane]
p-11Y PDGFRA D842Y [plasma membrane]
p-11Y PDGFRA D842_H845del [plasma membrane]
p-11Y PDGFRA D842_D846del [plasma membrane]
p-10Y PDGFRA Y849C [plasma membrane]
p-11Y PDGFRA D843_845del [plasma membrane]
p-11Y PDGFRA N848K [plasma membrane]
p-11Y PDGFRA D842L dimer [plasma membrane]
p-11Y PDGFRA D846V [plasma membrane]
p-11Y PDGFRA V536E [plasma membrane]
p-11Y PDGFRA V536M [plasma membrane]
p-11Y PDGFRA V561A [plasma membrane]
PDGFRA [plasma membrane]
p-11Y-PDGFRA [plasma membrane]
Modified Residues
Name
L-valine 561 replaced with L-aspartic acid
Coordinate
561
PsiMod
L-aspartic acid residue [MOD:00013]
A protein modification that effectively converts a source amino acid residue to an L-aspartic acid.
L-valine removal [MOD:01650]
A protein modification that effectively removes or replaces an L-valine.
Name
O4'-phospho-L-tyrosine at 1018
Coordinate
1018
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 572
Coordinate
572
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 574
Coordinate
574
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 720
Coordinate
720
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 731
Coordinate
731
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 742
Coordinate
742
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 754
Coordinate
754
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 762
Coordinate
762
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 768
Coordinate
768
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 988
Coordinate
988
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 849
Coordinate
849
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
gastrointestinal stromal tumor
DOID:9253
GANT, GIST, Stromal tumor of gastrointestinal tract
Cross References
RefSeq
NP_006197.1
,
NP_001334758.1
,
XP_005265800.1
ZINC - World Drugs
PGFRA_HUMAN
Guide to Pharmacology - Targets
1803
OpenTargets
ENSG00000134853
ZINC - FDA approved
PGFRA_HUMAN
ZINC - Substances
PGFRA_HUMAN
ZINC - Biogenic
PGFRA_HUMAN
ZINC target
P16234
PRO
P16234
PDB
6JOJ
,
8PQI
,
5K5X
,
7LBF
,
8PQH
,
6JOI
,
5GRN
,
6A32
,
7RAM
,
6JOL
,
8PQK
,
1GQ5
,
8PQJ
,
6JOK
ZINC - Investigational
PGFRA_HUMAN
COSMIC
COSM12395
,
COSV57265452
HPA
ENSG00000134853-PDGFRA
GeneCards
P16234
Ensembl
ENSP00000424218
,
ENSP00000257290
,
ENST00000257290
,
ENST00000509490
,
ENST00000508170
,
ENSP00000425648
,
ENSG00000134853
Pharos - Targets
P16234
ZINC - Predictions - Purchasable
PGFRA_HUMAN
Orphanet
16629
HMDB Protein
HMDBP01355
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01127 PDGFB
8
PDGFB (82-190) [extracellular region]
(R-HSA-184201)
PDGFB(82-241) [extracellular region]
(R-HSA-381904)
PDGFB(1-241) [endoplasmic reticulum lumen]
(R-HSA-381903)
PDGFB(1-241) [Golgi membrane]
(R-HSA-380740)
PDGFB(1-81) [Golgi lumen]
(R-HSA-389058)
PDGFB(191-241) [Golgi lumen]
(R-HSA-396945)
PDGFB(21-81) [platelet alpha granule lumen]
(R-HSA-184200)
PDGFB(82-241) [platelet alpha granule lumen]
(R-HSA-387075)
0.733
11
UniProt:P09619 PDGFRB
3
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
PDGFRB [plasma membrane]
(R-HSA-186767)
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
0.706
5
UniProt:P04085 PDGFA
1
PDGFA [extracellular region]
(R-HSA-2426265)
0.691
6
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.683
4
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.671
4
UniProt:Q9NRA1 PDGFC
0.656
3
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.569
3
UniProt:Q8N6L0 KASH5
0.556
3
UniProt:P19174 PLCG1
6
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
0.544
3
UniProt:Q8WVM8 SCFD1
1
SCFD1 [cytosol]
(R-HSA-5688147)
0.483
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text