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What is Reactome ?
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Team
Scientific Advisory Board
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Our Logo
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Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
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Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
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How do I search ?
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PDGFB (82-190) [extracellular region]
Stable Identifier
R-HSA-184201
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Platelet-derived growth factor, B chain, PDGF B-chain, Platelet-derived growth factor beta polypeptide, PDGF-2, c-sis, Becaplermin
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer (Homo sapiens)
FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
PDGFB homodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
HSPG2:FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer [extracellular region] (Homo sapiens)
PDGFB homodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [extracellular region] (Homo sapiens)
PDGF dimer [extracellular region] (Homo sapiens)
PDGF AB heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Autophosphorylation of PDGF alpha receptors (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Phospho PDGF alpha receptor:PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Autophosphorylation of PDGF alpha/beta receptors (Homo sapiens)
PDGF alpha/beta:PDGF AB and BB dimers [plasma membrane] (Homo sapiens)
PDGF AB or BB homodimers [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers [plasma membrane] (Homo sapiens)
PDGF AB or BB homodimers [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Autophosphorylation of PDGF beta receptors (Homo sapiens)
PDGF beta receptor:PDGF chain B homodimer [plasma membrane] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Phospho PDGF beta receptor: PDGF chain B homodimer [plasma membrane] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Downstream signal transduction (Homo sapiens)
Activated PLC gamma dissociates from the PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Activation of Src (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:MyrG-p-Y419-SRC [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Crk binds to the active PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
GAP binds to PDGF-beta receptors only (Homo sapiens)
Phospho PDGF beta receptor: PDGF chain B homodimer [plasma membrane] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Phospho-beta receptor homodimer:GAP [plasma membrane] (Homo sapiens)
Phospho PDGF beta receptor: PDGF chain B homodimer [plasma membrane] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
GRB2:SOS1 complex binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Grb7 binds to the active PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb7 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Nck binds to the active PDGF receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGFR receptor dimer:Nck [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PI3-kinase binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PLC-gamma binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Phosphorylation of PLCgamma by PDGFR (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:PLC-gamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGF:p-PDGFR dimer:p-PLCgamma [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
SH2 domain of Src binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:MyrG-SRC [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
SHP2 binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:SHP2 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
STAT binds to the active receptor (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGF:phospho-PDGF receptor dimer:STAT [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
p130Cas and C3G bind PDGFR bound Crk (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Homo sapiens)
PDGF:Phospho-PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGF dimer binds two receptors simultaneously (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGF:PDGF receptor dimer [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGF-AB clevage by Furin (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGF-BB clevage by Furin (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGFRs bind type I TKI (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
PDGF alpha receptor: PDGF dimers [plasma membrane] (Homo sapiens)
Active PDGF dimers (AA, AB, BB) [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
PTPN12 dephosphorylates PDGFRB at Y1021 (Homo sapiens)
p-PDGFRB homo and heterodimers [plasma membrane] (Homo sapiens)
Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers [plasma membrane] (Homo sapiens)
PDGF AB or BB homodimers [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Phospho PDGF beta receptor: PDGF chain B homodimer [plasma membrane] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
p-PDGFRB homo and heterodimers dephosphorylated at Y1021 [plasma membrane] (Homo sapiens)
Phospho PDGF alpha-beta dimer:PDGF AB or BB dimers dephosphorylated at Y1021 of PDGFRB [plasma membrane] (Homo sapiens)
PDGF AB or BB homodimers [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
Phospho PDGF beta receptor: PDGF chain B homodimer dephosphorylated at Y1021 [plasma membrane] (Homo sapiens)
active PDGF-BB dimer [extracellular region] (Homo sapiens)
Processed PDGF-B [extracellular region] (Homo sapiens)
PDGFB (82-190) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01127 PDGFB
Gene Names
PDGFB, PDGF2, SIS
Chain
signal peptide:1-20, propeptide:21-81, chain:82-190, propeptide:191-241
Reference Genes
BioGPS Gene:5155 PDGFB
COSMIC (genes):PDGFB PDGFB
CTD Gene:5155 PDGFB
dbSNP Gene:5155 PDGFB
ENSEMBL:ENSG00000100311 PDGFB
ENSEMBL_homo_sapiens_GENE:ENSG00000100311.17 PDGFB
HGNC:8800 PDGFB
KEGG Gene (Homo sapiens):5155 PDGFB
Monarch:5155 PDGFB
NCBI Gene:5155 PDGFB
OMIM:190040 PDGFB
UCSC:P01127 PDGFB
Reference Transcript
RefSeq:NM_033016.3 PDGFB
RefSeq:NM_002608.3 PDGFB
Other Identifiers
11731665_a_at
11731666_at
11731667_s_at
1573_at
16935228
204200_PM_s_at
204200_s_at
216061_PM_x_at
216061_x_at
217112_PM_at
217112_at
3961066
3961067
3961069
3961070
3961071
3961072
3961076
3961077
3961080
3961084
3961087
3961088
3961089
3961090
5155
8076195
A_24_P339944
GE60436
GO:0000139
GO:0000278
GO:0001892
GO:0001938
GO:0002376
GO:0002548
GO:0003013
GO:0003014
GO:0003104
GO:0005161
GO:0005515
GO:0005518
GO:0005576
GO:0005615
GO:0005737
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0005886
GO:0005975
GO:0006351
GO:0006355
GO:0006468
GO:0006629
GO:0007155
GO:0007165
GO:0007507
GO:0008083
GO:0008284
GO:0009611
GO:0009986
GO:0010467
GO:0010512
GO:0010544
GO:0010628
GO:0010629
GO:0010811
GO:0014911
GO:0016020
GO:0016176
GO:0016323
GO:0018108
GO:0023052
GO:0030154
GO:0030312
GO:0030335
GO:0031012
GO:0031093
GO:0031410
GO:0031954
GO:0032091
GO:0035655
GO:0035793
GO:0036120
GO:0036211
GO:0038001
GO:0042056
GO:0042060
GO:0042802
GO:0042803
GO:0043226
GO:0043406
GO:0043410
GO:0043536
GO:0045840
GO:0045892
GO:0045893
GO:0046982
GO:0048008
GO:0048018
GO:0048146
GO:0048407
GO:0048661
GO:0048856
GO:0048870
GO:0050731
GO:0050918
GO:0050921
GO:0051781
GO:0051897
GO:0060326
GO:0062023
GO:0070374
GO:0070528
GO:0071363
GO:0071506
GO:0072126
GO:0072255
GO:0072593
GO:0090280
GO:0098772
GO:0140014
GO:1900127
GO:1901135
GO:1902894
GO:1902895
GO:1904707
GO:1904754
GO:1905064
GO:1905176
GO:1990265
GO:2000379
GO:2000573
GO:2000591
HMNXSV003030572
Hs.172928.1.A1_3p_s_at
Hs.1976.2.S1_3p_at
ILMN_1737695
ILMN_1775822
ILMN_2394305
M12783_at
TC22000802.hg
X83705_s_at
g4505680_3p_a_at
Participates
as a component of
PDGF AB heterodimer [extracellular region] (Homo sapiens)
PDGFB homodimer [extracellular region] (Homo sapiens)
PDGF A/B heterodimer [extracellular region] (Homo sapiens)
as a member of
Processed PDGF-B [extracellular region] (Homo sapiens)
Other forms of this molecule
PDGFB(82-241) [extracellular region]
PDGFB(1-241) [endoplasmic reticulum lumen]
PDGFB(1-241) [Golgi membrane]
PDGFB(1-81) [Golgi lumen]
PDGFB(191-241) [Golgi lumen]
PDGFB(21-81) [platelet alpha granule lumen]
PDGFB(82-241) [platelet alpha granule lumen]
Inferred To
PDGFB (82-190) [extracellular region]
(Gallus gallus)
Pdgfb [extracellular region]
(Mus musculus)
Pdgfb [extracellular region]
(Rattus norvegicus)
Pvf1 [extracellular region]
(Drosophila melanogaster)
pdgfb [extracellular region]
(Xenopus tropicalis)
pdgfbb [extracellular region]
(Danio rerio)
PDGFB [extracellular region]
(Bos taurus)
PDGFB [extracellular region]
(Canis familiaris)
PDGFB [extracellular region]
(Sus scrofa)
pvf-1 [extracellular region]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_002599.1
,
NP_148937.1
OpenTargets
ENSG00000100311
ZINC - Substances
PDGFB_HUMAN
HPA
ENSG00000100311-PDGFB
GeneCards
P01127
ZINC target
P01127
Ensembl
ENSG00000100311
,
ENST00000381551
,
ENSP00000330382
,
ENST00000331163
,
ENSP00000370963
PRO
P01127
Pharos - Targets
P01127
ZINC - Predictions - Purchasable
PDGFB_HUMAN
Orphanet
17757
PDB
6T9E
,
3MJG
,
4HQU
,
4QCI
,
1PDG
,
4HQX
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P16234 PDGFRA
20
PDGFRA L629P [plasma membrane]
(R-HSA-9673596)
PDGFRA N659K [plasma membrane]
(R-HSA-9671535)
PDGFRA T674I [plasma membrane]
(R-HSA-9673603)
PDGFRA S601P [plasma membrane]
(R-HSA-9673600)
PDGFRA Y288C [endoplasmic reticulum membrane]
(R-HSA-9671971)
PDGFRA Y375_K455del [endoplasmic reticulum membrane]
(R-HSA-9673609)
p-11Y PDGFRA Y288C [endoplasmic reticulum membrane]
(R-HSA-9672027)
p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane]
(R-HSA-9673634)
PDGFRA D842_M844del [plasma membrane]
(R-HSA-9671526)
PDGFRA D842Y [plasma membrane]
(R-HSA-9671956)
PDGFRA D842V [plasma membrane]
(R-HSA-9671549)
PDGFRA I843_D846del [plasma membrane]
(R-HSA-9671537)
PDGFRA D842_H845del [plasma membrane]
(R-HSA-9671545)
PDGFRA D842del [plasma membrane]
(R-HSA-9671538)
PDGFRA D842_I843delinsV [plasma membrane]
(R-HSA-9671563)
PDGFRA D846Y [plasma membrane]
(R-HSA-9671958)
PDGFRA D843_845del [plasma membrane]
(R-HSA-9671552)
PDGFRA D842_D846del [plasma membrane]
(R-HSA-9671547)
PDGFRA N848K [plasma membrane]
(R-HSA-9671961)
PDGFRA Y849C [plasma membrane]
(R-HSA-9671974)
0.733
11
UniProt:Q9NW13 RBM28
1
RBM28 [nucleoplasm]
(R-HSA-6791192)
0.527
2
UniProt:Q9Y3T9 NOC2L
1
NOC2L [nucleoplasm]
(R-HSA-3222129)
0.527
2
UniProt:O60832 DKC1
1
DKC1 [nucleoplasm]
(R-HSA-163102)
0.527
2
UniProt:Q8WXG9 ADGRV1
1
GPR98 [plasma membrane]
(R-HSA-9618718)
0.527
2
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