p-11Y PDGFRA D842L dimer [plasma membrane]

Stable Identifier
R-HSA-9674313
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Alpha platelet-derived growth factor receptor, PGDS_HUMAN
Icon
p-11Y PDGFRA D842L dimer [plasma membrane] icon
p-11Y PDGFRA D842L dimer [plasma membrane] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
31723821 FIP1L1-PDGFRα p.T674I-D842L: A Novel and Ponatinib Resistant Compound Mutation in FIP1L1-PDGFRα Positive Leukemia

Smits, S, Appleby, N, Conneally, E, Vandenberghe, P, Michaux, L, Lierman, E

Hemasphere 2019
External Reference Information
External Reference
UniProt:P16234 PDGFRA
Gene Names
PDGFRA, PDGFR2, RHEPDGFRA
Chain
signal peptide:1-23, chain:24-1089
Reference Genes
COSMIC (genes):PDGFRA PDGFRA
dbSNP Gene:5156 PDGFRA
ENSEMBL:ENSG00000134853 PDGFRA
Participates
as a component of
Other forms of this molecule
PDGFRA L629P [plasma membrane]
PDGFRA N659K [plasma membrane]
PDGFRA T674I [plasma membrane]
PDGFRA S601P [plasma membrane]
PDGFRA Y288C [endoplasmic reticulum membrane]
PDGFRA Y375_K455del [endoplasmic reticulum membrane]
p-11Y PDGFRA Y288C [endoplasmic reticulum membrane]
p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane]
PDGFRA D842_M844del [plasma membrane]
PDGFRA D842Y [plasma membrane]
PDGFRA D842V [plasma membrane]
PDGFRA I843_D846del [plasma membrane]
PDGFRA D842_H845del [plasma membrane]
PDGFRA D842del [plasma membrane]
PDGFRA D842_I843delinsV [plasma membrane]
PDGFRA D846Y [plasma membrane]
PDGFRA D843_845del [plasma membrane]
PDGFRA D842_D846del [plasma membrane]
PDGFRA N848K [plasma membrane]
PDGFRA Y849C [plasma membrane]
PDGFRA D843_844del [plasma membrane]
PDGFRA D846V [plasma membrane]
PDGFRA D842L [plasma membrane]
PDGFRA V561D [plasma membrane]
PDGFRA V561A [plasma membrane]
PDGFRA V536E [plasma membrane]
PDGFRA V536M [plasma membrane]
p-11Y PDGFRA D842V [plasma membrane]
p-11Y PDGFRA D846Y [plasma membrane]
p-11Y-PDGFRA [plasma membrane]
PDGFRA [plasma membrane]
p-11Y PDGFRA V561A [plasma membrane]
p-11Y PDGFRA V561D [plasma membrane]
p-11Y PDGFRA V536M [plasma membrane]
p-11Y PDGFRA V536E [plasma membrane]
p-11Y PDGFRA D846V [plasma membrane]
p-11Y PDGFRA N848K [plasma membrane]
p-11Y PDGFRA D843_845del [plasma membrane]
p-10Y PDGFRA Y849C [plasma membrane]
p-11Y PDGFRA D842_D846del [plasma membrane]
p-11Y PDGFRA D842_H845del [plasma membrane]
p-11Y PDGFRA D842Y [plasma membrane]
p-11Y PDGFRA D843_846del [plasma membrane]
p-11Y-PDGFRA D842_I843delinsV [plasma membrane]
p-11Y PDGFRA D843_844del [plasma membrane]
p-11Y PDGFRA D842del [plasma membrane]
Modified Residues
Name
L-aspartic acid 842 replaced with L-leucine
Coordinate
842
PsiMod
L-leucine residue [MOD:00020]
A protein modification that effectively converts a source amino acid residue to an L-leucine.
L-aspartic acid removal [MOD:01634]
A protein modification that effectively removes or replaces an L-aspartic acid.
Name
O4'-phospho-L-tyrosine at 1018
Coordinate
1018
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 572
Coordinate
572
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 574
Coordinate
574
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 720
Coordinate
720
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 731
Coordinate
731
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 742
Coordinate
742
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 754
Coordinate
754
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 762
Coordinate
762
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 768
Coordinate
768
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 988
Coordinate
988
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 849
Coordinate
849
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
chronic myeloid leukemia DOID:8552 CML, chronic myelogenous leukemia, no ICD-O subtype (morphologic abnormality), chronic myeloid leukemia, disease (disorder), chronic myeloid leukemia without mention of remission, CML - chronic Myelogenous Leukemia, chronic myeloid leukemia in remission (disorder), Myeloid Leukemia, chronic, CML in Remission, chronic myeloid leukemia in remission, chronic myeloid leukaemia, chronic myeloid leukemia NOS (disorder)
Interactors (10)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P01127 PDGFB  8 0.733 11
 UniProt:P09619 PDGFRB  3 0.706 5
 UniProt:P04085 PDGFA  1 0.691 6
 UniProt:P00533 EGFR  20 0.683 4
 UniProt:P46108 CRK  1 0.671 4
 UniProt:Q9NRA1 PDGFC      0.656 3
 UniProt:P46109 CRKL  2 0.569 3
 UniProt:Q8N6L0 KASH5      0.556 3
 UniProt:P19174 PLCG1  6 0.544 3
 UniProt:Q8WVM8 SCFD1  1 0.483 2
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