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SPAST [cytosol]
Stable Identifier
R-HSA-9668426
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Spastin, fullName evidence="10 80"Spastin ecNumber evidence="10 37 40 45 48 50 65"5.6.1.1/ecNumber, SPAST_HUMAN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Sealing of the nuclear envelope (NE) by ESCRT-III (Homo sapiens)
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
SPAST [cytosol] (Homo sapiens)
SPAST [cytosol] (Homo sapiens)
SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
SPAST [cytosol] (Homo sapiens)
SPAST [cytosol] (Homo sapiens)
VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
SPAST [cytosol] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
SPAST [cytosol] (Homo sapiens)
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope] (Homo sapiens)
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
SPAST [cytosol] (Homo sapiens)
SPAST [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBP0 SPAST
Gene Names
SPAST, ADPSP, FSP2, KIAA1083, SPG4
Chain
chain:1-616
Reference Genes
BioGPS Gene:6683 SPAST
COSMIC (genes):SPAST SPAST
CTD Gene:6683 SPAST
dbSNP Gene:6683 SPAST
ENSEMBL:ENSG00000021574.13 SPAST
ENSEMBL:ENSG00000021574.14 SPAST
HGNC:11233 SPAST
KEGG Gene (Homo sapiens):6683 SPAST
Monarch:6683 SPAST
NCBI Gene:6683 SPAST
OMIM:604277 SPAST
UCSC:Q9UBP0 SPAST
Reference Transcript
RefSeq:NM_199436.1 SPAST
RefSeq:NM_014946.3 SPAST
Other Identifiers
11725243_a_at
11725244_a_at
16878748
207724_PM_s_at
207724_s_at
209748_PM_at
209748_at
2476076
2476077
2476078
2476079
2476080
2476086
2476087
2476090
2476094
2476095
2476097
2476099
2476100
2476103
2476104
2476105
2476107
2476109
2476110
2476111
2476112
2476113
2476114
2476115
35171_at
6683
8041236
A_14_P115672
A_23_P209356
A_24_P941988
GE53737
GO:0000166
GO:0000226
GO:0000278
GO:0000281
GO:0000910
GO:0000922
GO:0001578
GO:0003824
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005635
GO:0005654
GO:0005737
GO:0005768
GO:0005783
GO:0005789
GO:0005811
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005874
GO:0006888
GO:0007010
GO:0007018
GO:0007049
GO:0007084
GO:0007399
GO:0007409
GO:0008017
GO:0008089
GO:0008092
GO:0008152
GO:0008568
GO:0010458
GO:0015630
GO:0016020
GO:0016192
GO:0016787
GO:0016853
GO:0016887
GO:0019896
GO:0030154
GO:0030424
GO:0030496
GO:0031117
GO:0031410
GO:0031468
GO:0031965
GO:0032467
GO:0032506
GO:0034214
GO:0042995
GO:0043014
GO:0043226
GO:0044877
GO:0048471
GO:0048487
GO:0048856
GO:0051013
GO:0051228
GO:0051260
GO:0051301
GO:0061024
GO:0061640
GO:0065003
GO:0070062
GO:0071782
GO:0090148
GO:0140014
GO:0140096
GO:0140657
GO:1904115
HMNXSV003041390
ILMN_1791547
ILMN_1796738
ILMN_2373556
PH_hs_0026821
TC02000210.hg
g11875210_3p_a_at
g5689502_3p_at
Participates
as an output of
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)
as an input of
SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin (Homo sapiens)
as a component of
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST [nuclear envelope] (Homo sapiens)
Inferred To
Ghost homologue of SPAST [cytosol]
(Saccharomyces cerevisiae)
Ghost homologue of SPAST [cytosol]
(Schizosaccharomyces pombe)
SPAST [cytosol]
(Bos taurus)
SPAST [cytosol]
(Caenorhabditis elegans)
SPAST [cytosol]
(Canis familiaris)
SPAST [cytosol]
(Danio rerio)
SPAST [cytosol]
(Dictyostelium discoideum)
SPAST [cytosol]
(Drosophila melanogaster)
SPAST [cytosol]
(Gallus gallus)
SPAST [cytosol]
(Mus musculus)
SPAST [cytosol]
(Rattus norvegicus)
SPAST [cytosol]
(Sus scrofa)
SPAST [cytosol]
(Xenopus tropicalis)
Homologues of SPAST [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_955468.1
,
NP_055761.2
OpenTargets
ENSG00000021574
GeneCards
Q9UBP0
HPA
ENSG00000021574-SPAST
Ensembl
ENST00000644954
,
ENSP00000496589
,
ENSP00000494312
,
ENST00000315285
,
ENSG00000021574
,
ENST00000642999
,
ENSP00000320885
,
ENSP00000495015
,
ENST00000646571
PRO
Q9UBP0
Pharos - Targets
Q9UBP0
HMDB Protein
HMDBP11962
PDB
6PEK
,
3VFD
,
3EAB
,
7S7J
,
6PEN
,
5Z6R
,
5Z6Q
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WXF7-1 ATL1
0.593
4
UniProt:Q5T4F4 ZFY27
0.463
3
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