Reactome | IST1 [cytosol]

IST1 [cytosol]

Stable Identifier

R-HSA-9668516

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

IST1 homolog, IST1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P53990 IST1

Gene Names

IST1, KIAA0174

Chain

chain:1-364

Reference Genes

BioGPS Gene:9798 IST1

COSMIC (genes):IST1 IST1

CTD Gene:9798 IST1

dbSNP Gene:9798 IST1

ENSEMBL:ENSG00000182149.21 IST1

HGNC:28977 IST1

KEGG Gene (Homo sapiens):9798 IST1

Monarch:9798 IST1

NCBI Gene:9798 IST1

OMIM:616434 IST1

UCSC:P53990 IST1

Reference Transcript

Other Identifiers

11721808_x_at

11721809_a_at

11748532_a_at

11748533_x_at

11749259_x_at

11750291_a_at

11750292_x_at

1562848_PM_at

1562848_at

200851_PM_s_at

200851_s_at

3667767

3667768

3667769

3667772

3667779

3667780

3667781

3667784

3667787

3667788

3667789

3667790

3667792

3667797

3667800

3667801

3667802

3667803

36942_at

3832044

3832045

3832046

3832047

3832049

3832065

3832095

3832097

3832099

7997168

9798

A_23_P206759

A_24_P339157

D79996_at

GE57312

GE593672

GO:0000785

GO:0000910

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005694

GO:0005737

GO:0005764

GO:0005773

GO:0005793

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0007049

GO:0008104

GO:0009838

GO:0015031

GO:0019076

GO:0019904

GO:0030154

GO:0030496

GO:0031410

GO:0035578

GO:0036258

GO:0042802

GO:0043226

GO:0043231

GO:0044877

GO:0045184

GO:0045296

GO:0045862

GO:0046745

GO:0048668

GO:0048672

GO:0048856

GO:0051301

GO:0061640

GO:0070062

GO:0090541

GO:0090543

GO:1904903

HMNXSV003000296

HMNXSV003003760

Hs2.385724.1.S1_3p_at

ILMN_1740351

PH_hs_0023493

TC16000598.hg

TC16001626.hg

g7661971_3p_a_at

p6492

Participates

as an output of

VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope (Homo sapiens)

as an input of

CHMP7 binds CHMP4B, which recruits other subunits of the ESCRT-III complex (Homo sapiens)

as a component of

LEMD2:ESCRT-III:IST1 [nuclear envelope] (Homo sapiens)

Other forms of this molecule

IST1 [extracellular region]

IST1 [azurophil granule lumen]

Inferred To

ist1 [cytosol] (Schizosaccharomyces pombe)

ist1 [cytosol] (Xenopus tropicalis)

IST1 [cytosol] (Bos taurus)

IST1 [cytosol] (Canis familiaris)

IST1 [cytosol] (Dictyostelium discoideum)

IST1 [cytosol] (Gallus gallus)

IST1 [cytosol] (Saccharomyces cerevisiae)

IST1 [cytosol] (Sus scrofa)

Ist1 [cytosol] (Drosophila melanogaster)

Ist1 [cytosol] (Mus musculus)

Ist1 [cytosol] (Rattus norvegicus)

istr-1 [cytosol] (Caenorhabditis elegans)

zgc:55671 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_001257906.1, NP_055576.2, NP_001257905.1, NP_001257907.1, NP_001257904.1

OpenTargets

ENSG00000182149

HPA

ENSG00000182149-IST1

GeneCards

P53990

Ensembl

ENST00000541571, ENSP00000457844, ENST00000544564, ENSP00000455860, ENSP00000330408, ENST00000535424, ENST00000606369, ENSP00000438399, ENSP00000463711, ENSP00000368075, ENSP00000368076, ENSG00000182149, ENSP00000475853, ENST00000538850, ENST00000329908, ENST00000378798, ENST00000378799

PRO

P53990

Pharos - Targets

P53990

PDB

6TZ5, 7S7J, 4WZX, 3FRR, 6TZ4, 6TZA, 3FRS, 3JC1, 4U7Y, 6E8G, 4U7E, 4U7I

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13798 APEH	3	APEH [cytosol] (R-HSA-5691510) APEH [extracellular region] (R-HSA-6806454) APEH [ficolin-1-rich granule lumen] (R-HSA-6801068)	0.749	5
UniProt:Q9Y6W3 CAPN7	1	CAPN7 [cytosol] (R-HSA-8848633)	0.684	6
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q7Z479 Q7Z479			0.556	3
UniProt:P54253 ATX1			0.508	2