Reactome | IST1 [extracellular region]

IST1 [extracellular region]

Stable Identifier

R-HSA-6806231

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

IST1 homolog, IST1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P53990 IST1

Gene Names

IST1, KIAA0174

Chain

chain:1-364

Reference Genes

BioGPS Gene:9798 IST1

COSMIC (genes):IST1 IST1

CTD Gene:9798 IST1

dbSNP Gene:9798 IST1

ENSEMBL:ENSG00000182149 IST1

HGNC:28977 IST1

KEGG:hsa:9798 IST1

Monarch:9798 IST1

NCBI Gene:9798 IST1

OMIM:616434 IST1

UCSC:P53990 IST1

Reference Transcript

Participates

as a member of

Azurophil granule lumen proteins [extracellular region] (Homo sapiens)

Other forms of this molecule

IST1 [cytosol]

IST1 [azurophil granule lumen]

Inferred To

IST1 [extracellular region] (Bos taurus)

IST1 [extracellular region] (Canis familiaris)

IST1 [extracellular region] (Dictyostelium discoideum)

IST1 [extracellular region] (Gallus gallus)

IST1 [extracellular region] (Saccharomyces cerevisiae)

IST1 [extracellular region] (Sus scrofa)

istr-1 [extracellular region] (Caenorhabditis elegans)

Ist1 [extracellular region] (Drosophila melanogaster)

Ist1 [extracellular region] (Mus musculus)

Ist1 [extracellular region] (Rattus norvegicus)

ist1 [extracellular region] (Danio rerio)

ist1 [extracellular region] (Schizosaccharomyces pombe)

ist1 [extracellular region] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000182149

ENSEMBL

ENSG00000182149, ENSP00000463711, ENST00000544564, ENSP00000438399, ENST00000541571, ENST00000606369, ENST00000378798, ENST00000378799, ENSP00000330408, ENST00000329908, ENSP00000368075, ENST00000538850, ENSP00000368076, ENSP00000455860, ENSP00000457844, ENSP00000475853, ENST00000535424

HPA

ENSG00000182149-IST1

GeneCards

IST1

PRO

P53990

Pharos - Targets

P53990

GlyGen

P53990

PDB

7S7J, 3JC1, 6TZ5, 6TZ4, 4U7Y, 4WZX, 6E8G, 3FRS, 4U7I, 6TZA, 4U7E, 3FRR, 8UC6

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13798 APEH	3	APEH [cytosol] (R-HSA-5691510) APEH [extracellular region] (R-HSA-6806454) APEH [ficolin-1-rich granule lumen] (R-HSA-6801068)	0.749	5
UniProt:Q9Y6W3 CAPN7	1	CAPN7 [cytosol] (R-HSA-8848633)	0.684	6
UniProt:Q9Y2B5 VP9D1			0.564	2
UniProt:Q7Z479 Q7Z479			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q9UN37 VPS4A	1	VPS4A [cytosol] (R-HSA-917732)	0.527	2
UniProt:P54253 ATX1			0.508	2

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