Reactome | RPS27A(1-76) [late endosome lumen]

RPS27A(1-76) [late endosome lumen]

Stable Identifier

R-HSA-9660022

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

late endosome lumen

Synonyms

RPS27A, ubiquitin (RPS27A)

Locations in the PathwayBrowser

Expand all

Autophagy (Homo sapiens)

- Late endosomal microautophagy (Homo sapiens)
  - Substrate translocates into late endosomal lumen (Homo sapiens)
    - PL:HSPA8:Autophagy substrate [late endosome lumen] (Homo sapiens)
      - HSPA8 bound autophagic substrates [late endosome lumen] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [late endosome lumen] (Homo sapiens)
        
        Poly-vimentin:PolyUb-Misfolded Proteins:HDAC6 [late endosome lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins:HDAC6 [late endosome lumen] (Homo sapiens)
        
        PolyUb-Misfolded Proteins [late endosome lumen] (Homo sapiens)
        
        Ub-misfolded nascent CFTR [late endosome lumen] (Homo sapiens)
        
        Ub [late endosome lumen] (Homo sapiens)
        
        RPS27A(1-76) [late endosome lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62979 RPS27A

Gene Names

RPS27A, UBA80, UBCEP1

Chain

chain:1-76, chain:77-156

Reference Genes

BioGPS Gene:6233 RPS27A

COSMIC (genes):RPS27A RPS27A

CTD Gene:6233 RPS27A

dbSNP Gene:6233 RPS27A

ENSEMBL:ENSG00000143947 RPS27A

HGNC:10417 RPS27A

KEGG:hsa:6233 RPS27A

Monarch:6233 RPS27A

NCBI Gene:6233 RPS27A

OMIM:191343 RPS27A

UCSC:P62979 RPS27A

Reference Transcript

Other Identifiers

11741791_at

11744329_x_at

11759853_at

11759854_x_at

16654047

16654049

16654051

16654053

16880229

17119982

18670232

18670233

18670234

18670235

18670236

18670237

18670238

18670239

18670240

18670241

18670242

18670243

18670244

200017_PM_at

200017_at

242214_PM_at

242214_at

244624_PM_at

244624_at

2482925

2482926

2482927

2482928

2482929

2482930

2482931

2482932

2482933

2482934

2482935

2482936

2482937

2482938

2482939

2482940

2482941

2482942

2482944

2482946

34570_at

3694166

3694168

3694170

3694172

6233

7892717

7893392

7893455

7893919

7894376

7894650

7894813

7894844

7896021

7908407

8001782

8042052

83250_at

87675_at

A_14_P121993

A_14_P132160

A_23_P79732

GE716822

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005615

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005741

GO:0005789

GO:0005829

GO:0005840

GO:0005886

GO:0006412

GO:0010008

GO:0016020

GO:0016567

GO:0019941

GO:0022626

GO:0022627

GO:0030666

GO:0031386

GO:0031625

GO:0031982

GO:0032040

GO:0043226

GO:0045202

GO:0046872

GO:0070062

GO:1990904

HMNXSV003033635

Hs.311640.0.A1_3p_at

Hs.328922.0.A1_3p_at

ILMN_1755883

ILMN_2048326

S79522_at

TC01004921.hg

TC02000321.hg

g4506712_3p_at

g4506712_3p_x_at

Participates

as a member of

Ub [late endosome lumen] (Homo sapiens)

Other forms of this molecule

RPS27A(1-76) [endocytic vesicle membrane]

RPS27A(77-156) [nucleoplasm]

Ub-33-RPS27A(1-76) [mitochondrial outer membrane]

Ub-63-RPS27A(1-76) [mitochondrial outer membrane]

Ub-6-RPS27A(1-76) [mitochondrial outer membrane]

Ub-11-RPS27A(1-76) [mitochondrial outer membrane]

Ub-48-RPS27A(1-76) [mitochondrial outer membrane]

Ub-29-RPS27A(1-76) [mitochondrial outer membrane]

Ub-63-RPS27A(1-76) [cytosol]

RPS27A(1-76) [lysosomal lumen]

RPS27A(1-76) [cytosol]

p-S65-RPS27A(1-76) [mitochondrial outer membrane]

Ub-48-RPS27A(1-76) [cytosol]

RPS27A(1-76) [mitochondrial outer membrane]

Ub-6-RPS27A(1-76) [nucleoplasm]

Ub-63-RPS27A(1-76) [nucleoplasm]

Ub-48-RPS27A(1-76) [nucleoplasm]

RPS27A(1-76) [nucleoplasm]

Ub-63-RPS27A(1-76) [plasma membrane]

Ub-63-RPS27A(1-76) [endosome membrane]

Ub-11-RPS27A(1-76) [cytosol]

Ub-11-RPS27A(1-76) [nucleoplasm]

Ub-33-RPS27A(1-76) [nucleoplasm]

Ub-29-RPS27A(1-76) [nucleoplasm]

Ub-27-RPS27A(1-76) [nucleoplasm]

RPS27A(1-76) [endoplasmic reticulum membrane]

RPS27A(77-156) [cytosol]

M1-RPS27A(1-76) [cytosol]

Ub-33-RPS27A(1-76) [cytosol]

Ub-27-RPS27A(1-76) [cytosol]

Ub-6-RPS27A(1-76) [cytosol]

Ub-29-RPS27A(1-76) [cytosol]

RPS27A(1-76) [plasma membrane]

RPS27A(1-76) [endosome membrane]

Ub-48-RPS27A(1-76) [endocytic vesicle membrane]

Ub-48-RPS27A(1-76) [lysosomal membrane]

Ub-48-RPS27A(1-76) [endoplasmic reticulum membrane]

adenylatedlG76-RPS27A(1-76) [cytosol]

RPS27A [cytosol]

adenylatedlG76-RPS27A(1-76) [nucleoplasm]

N6-glycyl-L-lysine-RPS27A(1-76) [cytosol]

Ub-27-RPS27A(1-76) [mitochondrial outer membrane]

Cross References

RefSeq

NP_002945.1, NP_001170884.1, NP_001129064.1

OpenTargets

ENSG00000143947

ENSEMBL

ENSP00000272317, ENST00000404735, ENSP00000383981, ENST00000272317, ENSG00000143947, ENST00000402285, ENSP00000385659

GeneCards

RPS27A

HPA

ENSG00000143947-RPS27A

PRO

P62979

Pharos - Targets

P62979

GlyGen

P62979

PDB

6IP5, 8G6J, 7TQL, 8PJ1, 8XSX, 6ZVH, 6ZXG, 8PJ5, 5A2Q, 2KTF, 9G8M, 3PHD, 6YBS, 3TBL, 8XXN, 6Y0G, 6G5H, 7K5I, 7MQA, 8G61, 5WVO, 2L0T, 6ZMT, 8K2C, 3PHW, 6XA1, 7WTW, 6OLE, 6ZV6, 7BWD, 7JQB, 3K9P, 6KIV, 3NHE, 6J99, 2KOX, 6G51, 6SQR, 8HTF, 6ZXD, 6ZP4, 6Z6N, 7A09, 6IP6, 8OZ0, 2XK5, 5LKS, 8IFE, 7XNY, 4UG0, 2KHW, 9BKD, 8YOP, 2KWU, 8XXM, 7JQC, 8PPK, 6G5I, 3AXC, 6DC6, 6ZOJ, 2L0F, 8G60, 6OLF, 7F0N, 7WTV, 3N32, 6OLI, 7WTZ, 6ZXE, 6Z6L, 8HTC, 3NS8, 8IFD, 6ZXH, 6ZLW, 8XSZ, 8PJ3, 6Y57, 8PJ4, 6IP8, 6OLZ, 6KG6, 8XXL, 6ZUO, 4R62, 6ZM7, 5AJ0, 8X7I, 7WTU, 6SQO, 8T4S, 8G5Y, 6ZMW, 3N30, 6ZMI, 3VDZ, 6ZON, 6KIU, 5T2C, 8IVB, 5FLX, 6ZVJ, 6SQS, 8XSY, 7MQ9, 8X7J, 7QP7, 6OM7, 6ZXF, 9BLN, 8PJ2, 7WU0, 8YOO, 7R4X, 6FEC, 9IPU, 8PJ6, 8PPL, 7OOJ, 6G18, 2KWV, 8GLP, 4V6X, 6OLG, 6ZME, 5YDK, 7WTT, 3NOB, 6ZMO, 6OM0, 6ZN5, 7WTX, 6KIW, 6Z6M, 6QZP, 6G53, 6ZOL, 8QOI, 3I3T, 6KFP, 7QP6

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15038 DAZP2			0.781	9
UniProt:Q9Y3C5 RNF11			0.666	4
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.607	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q99732 LITAF			0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:Q9NRQ2 PLS4			0.556	3
UniProt:I6L9I8 I6L9I8			0.556	3
UniProt:Q8N3F0 MTURN			0.556	3
UniProt:Q96CS7 PKHB2			0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.556	3
UniProt:Q92567-2 FAM168A			0.556	3
UniProt:Q6ICB0 DESI1			0.556	3
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	3
UniProt:Q9BXY0 MAK16			0.527	2
UniProt:Q9BSL1 UBAC1	1	UBAC1 [cytosol] (R-HSA-8851644)	0.527	2
UniProt:Q6AW86 ZNF324B	1	ZNF324B [nucleoplasm] (R-HSA-3323092)	0.527	2
UniProt:Q96H86 ZNF764	1	ZNF764 [nucleoplasm] (R-HSA-3343766)	0.527	2
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	2
UniProt:O14978 ZNF263	1	ZNF263 [nucleoplasm] (R-HSA-1027393)	0.527	2
UniProt:Q8N998 CCD89			0.527	2
UniProt:Q5VT40 FA78B			0.527	2
UniProt:P08311 CTSG	4	CTSG [cytosol] (R-HSA-9635429) CTSG [extracellular region] (R-HSA-2228716) CTSG [plasma membrane] (R-HSA-538738) CTSG [azurophil granule lumen] (R-HSA-6799137)	0.527	2
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	6
UniProt:Q9BT49 THAP7			0.527	2
UniProt:Q9NQZ8 ZNF71	1	ZNF71 [nucleoplasm] (R-HSA-2454145)	0.527	2
UniProt:Q7RTS1 BHLHA15	1	BHLHA15 [nucleoplasm] (R-HSA-9922593)	0.527	2
UniProt:P08865 RPSA	2	RPSA [cytosol] (R-HSA-72389) RPSA [nucleoplasm] (R-HSA-6798722)	0.527	2
UniProt:Q9H9D4 ZN408			0.527	2
UniProt:P21741 MDK	1	MDK [extracellular region] (R-HSA-2160953)	0.527	2
UniProt:Q66K89 E4F1			0.527	2
UniProt:P18206 VCL	8	VCL [cytosol] (R-HSA-350753) VCL [ficolin-1-rich granule lumen] (R-HSA-6800985) VCL [extracellular region] (R-HSA-350736) VCL [secretory granule lumen] (R-HSA-6801010) VCL [specific granule lumen] (R-HSA-6799711) VCL(95 kDa) [cytosol] (R-HSA-9861471) VCL(1-811)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713480) VCL(1-811)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713472)	0.527	2
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.527	2

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