Reactome | GPER1 signaling

GPER1 signaling

Stable Identifier

R-HSA-9634597

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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GPER1 (also known as GPR30) is an orphan G-protein coupled receptor that has been suggested to act as an alternate estrogen receptor (Revankar et al, 2005; Filardo et al, 2007; reviewed in Prossnitz and Barton, 2011; Gaudet et al, 2015). In support of this, a number of studies have shown that GPER1 stimulates MAPK and cAMP activation in response to estrogen in ESR1 negative breast cancer cells. Similar to classical ESR1-mediated signaling, this estrogen-responsive GPER1 is suggested to act through G beta gamma and to involve EGFR transactivation (Filardo et al, 2000; Filardo et al, 2002; reviewed in Filardo and Thomas, 2012).

Literature References

PubMed ID	Title	Journal	Year
22495674	Minireview: G protein-coupled estrogen receptor-1, GPER-1: its mechanism of action and role in female reproductive cancer, renal and vascular physiology Filardo, EJ, Thomas, P	Endocrinology	2012
21844907	The G-protein-coupled estrogen receptor GPER in health and disease Prossnitz, ER, Barton, M	Nat Rev Endocrinol	2011
26190834	The G-protein coupled estrogen receptor, GPER: The inside and inside-out story Gaudet, HM, Cheng, SB, Christensen, EM, Filardo, EJ	Mol. Cell. Endocrinol.	2015
28595943	A role for G-protein coupled estrogen receptor (GPER) in estrogen-induced carcinogenesis: Dysregulated glandular homeostasis, survival and metastasis Filardo, EJ	J. Steroid Biochem. Mol. Biol.	2018
11773440	Estrogen action via the G protein-coupled receptor, GPR30: stimulation of adenylyl cyclase and cAMP-mediated attenuation of the epidermal growth factor receptor-to-MAPK signaling axis Filardo, EJ, Quinn, JA, Frackelton, AR, Bland, KI	Mol. Endocrinol.	2002