Reactome | cAMP induces dissociation of inactive PKA tetramers

cAMP induces dissociation of inactive PKA tetramers

Stable Identifier

R-HSA-111925

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Leishmania parasite growth and survival (Homo sapiens)
        
        Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
        
        FCGR3A-mediated IL10 synthesis (Homo sapiens)
        
        cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)
        
        cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        PKA-mediated phosphorylation of CREB (Homo sapiens)
        
        PKA activation (Homo sapiens)
        
        cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        DARPP-32 events (Homo sapiens)
        
        cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        PKA-mediated phosphorylation of CREB (Homo sapiens)
        
        PKA activation (Homo sapiens)
        
        cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - GPER1 signaling (Homo sapiens)
        
        cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)

General

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cAMP induces dissociation of inactive PKA tetramers

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The protein kinase A (PKA) regulatory subunit isoforms differ in their tissue specificity and functional characteristics. The specific isoform activated in response to glucagon signaling is not known. The PKA kinase is a tetramer of two regulatory and two catalytic subunits. The regulatory subunits block the catalytic subunits. Binding of cAMP to the regulatory subunit triggers dissociation of the tetramer into two active dimers made up of a regulatory and a catalytic subunit.

Literature References