Recruitment of TRAF3 to MAVS

Stable Identifier
R-HSA-918227
Type
Reaction
Species
Homo sapiens
Related Species
Influenza A virus, Rotavirus, Hepatitis C Virus, Measles virus
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TRAF3 a E3 ligase for K63-linked polyubiquitination, is one of the critical molecules required for mediating IPS-1 dependent type I IFN production. TRAF3 interacts directly with IPS-1 through the TRAF domain of TRAF3 and a TRAF-interaction motif (TIM) with in IPS-1.

Literature References
PubMed ID Title Journal Year
16306936 Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

Perry, A, Saha, SK, Oganesyan, G, He, JQ, Guo, B, Shahangian, A, Cheng, G, Zarnegar, B

Nature 2006
17190786 Antiviral signaling through pattern recognition receptors

Kawai, T, Akira, S

J Biochem 2007
16858409 Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif

Pietras, EM, Saha, SK, Oganesyan, G, He, JQ, Wang, Y, Shahangian, A, Kang, JR, Cheng, G, Zarnegar, B, Liu, SY, Shiba, TL

EMBO J 2006
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!