TRAF3 a E3 ligase for K63-linked polyubiquitination, is one of the critical molecules required for mediating IPS-1 dependent type I IFN production. TRAF3 interacts directly with IPS-1 through the TRAF domain of TRAF3 and a TRAF-interaction motif (TIM) with in IPS-1.
Perry, A, Saha, SK, Oganesyan, G, He, JQ, Guo, B, Shahangian, A, Cheng, G, Zarnegar, B
Kawai, T, Akira, S
Pietras, EM, Saha, SK, Oganesyan, G, He, JQ, Wang, Y, Shahangian, A, Kang, JR, Cheng, G, Zarnegar, B, Liu, SY, Shiba, TL
© 2023 Reactome