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viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane]
Stable Identifier
R-HSA-918200
Type
Complex
Species
Homo sapiens
Related Species
Rotavirus,
Influenza A virus,
Hepatitis C Virus,
Measles virus
Compartment
mitochondrial outer membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
OTUD5 deubiquitinates TRAF3 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
TRAF3-dependent IRF activation pathway (Homo sapiens)
Phosphorylation and release of IRF3/IRF7 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
Recruitment of IRF3,IRF7 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon:IRF3,IRF7 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
Recruitment of TRAF3 to MAVS (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
TBK1/IKK epsilon complex interacts with MAVS bound TRAF3 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ovarian tumor domain proteases (Homo sapiens)
OTUD5 deubiquitinates TRAF3 (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3 [mitochondrial outer membrane] (Homo sapiens)
Participants
components
K63polyUb-TRAF3 [cytosol] (Homo sapiens)
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS [mitochondrial outer membrane] (Homo sapiens)
Participant Of
input
OTUD5 deubiquitinates TRAF3
TBK1/IKK epsilon complex interacts with MAVS bound TRAF3
output
Recruitment of TRAF3 to MAVS
hasComponent
viral dsRNA:IFIH1, viral dsRNA:K63polyUb-DDX58:MAVS:K63polyUb-TRAF3:IKK related kinases TBK1/IKK epsilon [mitochondrial outer membrane]
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