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LHX4 [nucleoplasm]
Stable Identifier
R-HSA-9010585
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
LIM/homeobox protein Lhx4, LHX4_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
ISL1 binds the SLIT2 gene enhancer (Homo sapiens)
ISL1:LHX3/4:LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX4:LDB1 [nucleoplasm] (Homo sapiens)
LHX4 [nucleoplasm] (Homo sapiens)
ISL1:LHX3/4:LDB1:SLIT2 gene [nucleoplasm] (Homo sapiens)
ISL1:LHX3/4:LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX4:LDB1 [nucleoplasm] (Homo sapiens)
LHX4 [nucleoplasm] (Homo sapiens)
SLIT2 gene expression is stimulated by ISL1 (Homo sapiens)
ISL1:LHX3/4:LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX4:LDB1 [nucleoplasm] (Homo sapiens)
LHX4 [nucleoplasm] (Homo sapiens)
ISL1:LHX3/4:LDB1:SLIT2 gene [nucleoplasm] (Homo sapiens)
ISL1:LHX3/4:LDB1 [nucleoplasm] (Homo sapiens)
ISL1:LHX4:LDB1 [nucleoplasm] (Homo sapiens)
LHX4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q969G2 LHX4
Gene Names
LHX4
Chain
chain:1-390
Reference Genes
BioGPS Gene:89884 LHX4
COSMIC (genes):LHX4 LHX4
CTD Gene:89884 LHX4
dbSNP Gene:89884 LHX4
ENSEMBL:ENSG00000121454 LHX4
HGNC:21734 LHX4
KEGG Gene (Homo sapiens):89884 LHX4
Monarch:89884 LHX4
NCBI Gene:89884 LHX4
OMIM:602146 LHX4
UCSC:Q969G2 LHX4
Reference Transcript
RefSeq:NM_033343.3 LHX4
Other Identifiers
0005340605
0103610132
11740405_at
11740406_at
1553156_at
1553157_at
16674540
232781_at
2370033
2370034
2370035
2370038
2370054
2370055
2370057
2370058
2370060
2370061
2370062
2370063
2370065
2370067
57414_at
7907849
89884
A_14_P116523
A_23_P23869
A_32_P310219
GO:0000003
GO:0000228
GO:0000790
GO:0000902
GO:0000977
GO:0000981
GO:0001228
GO:0001890
GO:0003674
GO:0003677
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005694
GO:0006355
GO:0006357
GO:0008045
GO:0008150
GO:0008219
GO:0008327
GO:0009058
GO:0009887
GO:0021526
GO:0030154
GO:0030182
GO:0034641
GO:0040011
GO:0043066
GO:0043167
GO:0043226
GO:0043565
GO:0045944
GO:0046872
GO:0048856
GO:1990837
Hs.120127.0.S1_3p_at
Hs2.152082.1.S1_3p_at
Hs2.152082.1.S2_3p_at
ILMN_1674366
PH_hs_0006630
PH_hs_0023260
TC01001561.hg
Participant Of
hasComponent
ISL1:LHX4:LDB1 [nucleoplasm]
Cross References
RefSeq
NP_203129.1
OpenTargets
ENSG00000121454
GeneCards
Q969G2
HPA
ENSG00000121454-LHX4
Ensembl
ENST00000263726
,
ENSG00000121454
,
ENSP00000263726
PRO
Q969G2
Orphanet
16786
PDB
5HOD
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5N6 ORC6
1
ORC6 [nucleoplasm]
(R-HSA-68539)
0.781
8
UniProt:O75604 USP2
2
USP2 [cytosol]
(R-HSA-5212661)
USP2 [nucleoplasm]
(R-HSA-5689946)
0.666
4
UniProt:O15169 AXIN1
11
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
AXIN1 [cytosol]
(R-HSA-195249)
p-T519,S524,S531-AXIN1 [cytosol]
(R-HSA-206040)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
0.556
3
UniProt:P25490 YY1
1
YY1 [nucleoplasm]
(R-HSA-4086091)
0.556
3
UniProt:P36404 ARL2
2
ARL2 [cytosol]
(R-HSA-5216230)
ARL2 [mitochondrial matrix]
(R-HSA-5250216)
0.556
3
UniProt:P61371 ISL1
1
ISL1 [nucleoplasm]
(R-HSA-400478)
0.547
2
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