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PAF1C [nucleoplasm]
Stable Identifier
R-HSA-8866690
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Pre-transcription Events (Homo sapiens)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
Abortive termination of elongation after arrest (Homo sapiens)
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
Elongating transcript encounters a lesion in the template (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
Resumption of elongation after recovery from pausing (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
TFIIS-mediated recovery of elongation from arrest (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription Elongation (Homo sapiens)
Addition of nucleotides leads to transcript elongation (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
Formation of RNA Pol II elongation complex (Homo sapiens)
Recruitment of elongation factors to form elongation complex (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
Pol II elongation complex moves on the template as transcript elongates (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
Separation of elongating transcript from template (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
RNF20:RNF40 monoubiquitinates Histone H2B (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B [nucleoplasm] (Homo sapiens)
PAF1C [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
26659056
RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II
Tang, Z
,
Yu, M
,
Roeder, RG
,
Zhu, J
,
Ni, T
,
Nakadai, T
,
Yang, W
Science
2015
Participants
components
CDC73 [nucleoplasm]
(Homo sapiens)
CTR9 [nucleoplasm]
(Homo sapiens)
LEO1 [nucleoplasm]
(Homo sapiens)
PAF1 [nucleoplasm]
(Homo sapiens)
RTF1 [nucleoplasm]
(Homo sapiens)
WDR61 [nucleoplasm]
(Homo sapiens)
Participates
as an output of
RNF20:RNF40 monoubiquitinates Histone H2B (Homo sapiens)
Elongating transcript encounters a lesion in the template (Homo sapiens)
as a component of
PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B [nucleoplasm] (Homo sapiens)
Aborted elongation complex after arrest [nucleoplasm] (Homo sapiens)
Paused processive elongation complex [nucleoplasm] (Homo sapiens)
Arrested processive elongation complex [nucleoplasm] (Homo sapiens)
Elongation complex with separated and uncleaved transcript [nucleoplasm] (Homo sapiens)
Elongation complex prior to separation [nucleoplasm] (Homo sapiens)
Processive elongation complex [nucleoplasm] (Homo sapiens)
Elongation complex [nucleoplasm] (Homo sapiens)
as an input of
RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Homo sapiens)
Recruitment of elongation factors to form elongation complex (Homo sapiens)
Inferred To
PAF1C [nucleoplasm]
(Bos taurus)
PAF1C [nucleoplasm]
(Caenorhabditis elegans)
PAF1C [nucleoplasm]
(Canis familiaris)
PAF1C [nucleoplasm]
(Danio rerio)
PAF1C [nucleoplasm]
(Dictyostelium discoideum)
PAF1C [nucleoplasm]
(Drosophila melanogaster)
PAF1C [nucleoplasm]
(Gallus gallus)
PAF1C [nucleoplasm]
(Mus musculus)
PAF1C [nucleoplasm]
(Rattus norvegicus)
PAF1C [nucleoplasm]
(Saccharomyces cerevisiae)
PAF1C [nucleoplasm]
(Schizosaccharomyces pombe)
PAF1C [nucleoplasm]
(Sus scrofa)
PAF1C [nucleoplasm]
(Xenopus tropicalis)
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