Reactome | LEO1 [nucleoplasm]

LEO1 [nucleoplasm]

Stable Identifier

R-HSA-3322361

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RDL

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q8WVC0 LEO1

Gene Names

LEO1, RDL

Chain

initiator methionine:, chain:2-666

Reference Genes

BioGPS Gene:123169 LEO1

COSMIC (genes):LEO1 LEO1

CTD Gene:123169 LEO1

dbSNP Gene:123169 LEO1

ENSEMBL:ENSG00000166477 LEO1

HGNC:30401 LEO1

KEGG:hsa:123169 LEO1

Monarch:123169 LEO1

NCBI Gene:123169 LEO1

OMIM:610507 LEO1

UCSC:Q8WVC0 LEO1

Reference Transcript

Other Identifiers

11723233_a_at

123169

16809346

235096_PM_at

235096_at

3624355

3624363

3624364

3624366

3624368

3624369

3624370

3624371

3624372

3624374

3624375

3624377

3624378

3624380

3624381

53272_i_at

53273_r_at

7988838

A_23_P314222

A_33_P3270109

GO:0001650

GO:0001711

GO:0005515

GO:0005634

GO:0005654

GO:0005813

GO:0005815

GO:0006355

GO:0006368

GO:0016055

GO:0016071

GO:0016593

GO:0019827

GO:0031124

GO:0032968

GO:0043226

GO:0045638

GO:0045944

GO:1990269

HMNXSV003054848

Hs.296420.0.A1_3p_at

ILMN_1801553

ILMN_1804451

PH_hs_0030230

TC15001449.hg

Participates

as a component of

as an input of

Beta-catenin recruits CDC73 and LEO1 (Homo sapiens)

Inferred To

Atu [nucleoplasm] (Drosophila melanogaster)

leo-1 [nucleoplasm] (Caenorhabditis elegans)

Leo1 [nucleoplasm] (Mus musculus)

Leo1 [nucleoplasm] (Rattus norvegicus)

leo1 [nucleoplasm] (Danio rerio)

leo1 [nucleoplasm] (Dictyostelium discoideum)

leo1 [nucleoplasm] (Xenopus tropicalis)

LEO1 [nucleoplasm] (Bos taurus)

LEO1 [nucleoplasm] (Canis familiaris)

LEO1 [nucleoplasm] (Gallus gallus)

LEO1 [nucleoplasm] (Saccharomyces cerevisiae)

LEO1 [nucleoplasm] (Schizosaccharomyces pombe)

LEO1 [nucleoplasm] (Sus scrofa)

Cross References

ENSEMBL

ENST00000315141, ENSG00000166477, ENSP00000314610, ENST00000299601, ENSP00000299601

OpenTargets

ENSG00000166477

GeneCards

LEO1

HPA

ENSG00000166477-LEO1

PRO

Q8WVC0

Pharos - Targets

Q8WVC0

GlyGen

Q8WVC0

PDB

7UND, 7UNC, 7OOP, 8A3Y, 7OPC, 4M6T, 7OPD, 6GMH, 6TED

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N7H5 PAF1	1	PAF1 [nucleoplasm] (R-HSA-8866689)	0.949	30
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.932	19
UniProt:Q6PD62 CTR9	1	CTR9 [nucleoplasm] (R-HSA-8866694)	0.789	15
UniProt:Q9GZS3 SKIC8	2	WDR61 [cytosol] (R-HSA-8931534) WDR61 [nucleoplasm] (R-HSA-8866696)	0.725	7
UniProt:P23193 TCEA1	1	TCEA1 [nucleoplasm] (R-HSA-65748)	0.577	4
UniProt:O75764 TCEA3			0.556	3
UniProt:Q6PI77 GASP3			0.556	3
UniProt:Q92541 RTF1	1	RTF1 [nucleoplasm] (R-HSA-8866693)	0.527	5
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.527	3
UniProt:Q14241 ELOA	1	TCEB3 [nucleoplasm] (R-HSA-112421)	0.508	2