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S100A12 [extracellular region]
Stable Identifier
R-HSA-879450
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Protein S100-A12, S10AC_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100A12 dimer [extracellular region] (Homo sapiens)
S100A12 [extracellular region] (Homo sapiens)
Innate Immune System (Homo sapiens)
Advanced glycosylation endproduct receptor signaling (Homo sapiens)
AGER binds ERK1/2 (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100A12 dimer [extracellular region] (Homo sapiens)
S100A12 [extracellular region] (Homo sapiens)
AGER ligands:AGER:ERK [plasma membrane] (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100A12 dimer [extracellular region] (Homo sapiens)
S100A12 [extracellular region] (Homo sapiens)
Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100A12 dimer [extracellular region] (Homo sapiens)
S100A12 [extracellular region] (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100A12 dimer [extracellular region] (Homo sapiens)
S100A12 [extracellular region] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100A12 dimer [extracellular region] (Homo sapiens)
S100A12 [extracellular region] (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
S100A12 [extracellular region] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100A12 dimer [extracellular region] (Homo sapiens)
S100A12 [extracellular region] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100A12 dimer [extracellular region] (Homo sapiens)
S100A12 [extracellular region] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100A12 dimer [extracellular region] (Homo sapiens)
S100A12 [extracellular region] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100A12 dimer [extracellular region] (Homo sapiens)
S100A12 [extracellular region] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100A12 dimer [extracellular region] (Homo sapiens)
S100A12 [extracellular region] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100A12 dimer [extracellular region] (Homo sapiens)
S100A12 [extracellular region] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100A12 dimer [extracellular region] (Homo sapiens)
S100A12 [extracellular region] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100A12 dimer [extracellular region] (Homo sapiens)
S100A12 [extracellular region] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
AGER ligands:AGER [plasma membrane] (Homo sapiens)
AGER ligands [extracellular region] (Homo sapiens)
S100A12 dimer [extracellular region] (Homo sapiens)
S100A12 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P80511 S100A12
Gene Names
S100A12
Chain
initiator methionine:, chain:2-92, peptide:78-92
Reference Genes
BioGPS Gene:6283 S100A12
COSMIC (genes):S100A12 S100A12
CTD Gene:6283 S100A12
dbSNP Gene:6283 S100A12
ENSEMBL:ENSG00000163221 S100A12
HGNC:10489 S100A12
KEGG:hsa:6283 S100A12
Monarch:6283 S100A12
NCBI Gene:6283 S100A12
OMIM:603112 S100A12
UCSC:P80511 S100A12
Reference Transcript
RefSeq:NM_005621.1 S100A12
Other Identifiers
11725138_at
16693409
205863_PM_at
205863_at
2435982
2435983
2435984
2435985
38879_at
6283
7920238
A_23_P74001
A_33_P3385785
D83657_at
GE57334
GO:0002376
GO:0002548
GO:0005507
GO:0005509
GO:0005515
GO:0005576
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006355
GO:0006805
GO:0006954
GO:0008270
GO:0030593
GO:0031640
GO:0034774
GO:0042742
GO:0042802
GO:0043123
GO:0043226
GO:0043406
GO:0043542
GO:0045087
GO:0045576
GO:0046872
GO:0048306
GO:0048870
GO:0050729
GO:0050786
GO:0050832
GO:0051092
GO:0061844
GO:0098542
HMNXSV003000001
ILMN_1748915
PH_hs_0001709
TC01003260.hg
g5032058_3p_at
Participates
as a member of
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
as a component of
S100A12 dimer [extracellular region] (Homo sapiens)
Other forms of this molecule
S100A12 [secretory granule lumen]
Inferred To
s100a10b [extracellular region]
(Danio rerio)
Homologues of S100A12 [extracellular region]
(Danio rerio)
Homologues of S100A12 [extracellular region]
(Sus scrofa)
S100A12 [extracellular region]
(Bos taurus)
S100A12 [extracellular region]
(Canis familiaris)
S100A12 [extracellular region]
(Sus scrofa)
s100a10a [extracellular region]
(Danio rerio)
s100a11 [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_005612.1
ENSEMBL
ENSP00000357726
,
ENST00000368737
OpenTargets
ENSG00000163221
HPA
ENSG00000163221-S100A12
PRO
P80511
Pharos - Targets
P80511
PDB
2WC8
,
1ODB
,
1E8A
,
2M9G
,
2WCE
,
1GQM
,
2WCB
,
2WCF
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
calcium(2+) [ChEBI:29108]
20
Ca2+ [platelet dense granule lumen]
(R-ALL-114582)
Ca2+ [endosome membrane]
(R-ALL-5210949)
Ca2+ [sarcoplasmic reticulum lumen]
(R-ALL-2855229)
Ca2+ [mitochondrial intermembrane space]
(R-ALL-8949232)
Ca2+ [lysosomal lumen]
(R-ALL-1606834)
Ca2+ [endocytic vesicle lumen]
(R-ALL-8851519)
Ca2+ [endoplasmic reticulum-Golgi intermediate compartment]
(R-ALL-9706979)
Ca2+ [Golgi lumen]
(R-ALL-167012)
Ca2+ [platelet dense tubular network lumen]
(R-ALL-139827)
Ca2+ [platelet dense tubular network membrane]
(R-ALL-141090)
Ca2+ [plasma membrane]
(R-ALL-140648)
Ca2+ [secretory granule lumen]
(R-ALL-216801)
Ca2+ [nuclear envelope]
(R-ALL-2318767)
Ca2+ [nucleoplasm]
(R-ALL-29496)
Ca2+ [mitochondrial matrix]
(R-ALL-8949220)
Ca2+ [mitochondrial inner membrane]
(R-ALL-1524102)
Ca2+ [endoplasmic reticulum membrane]
(R-ALL-1500625)
Ca2+ [cytosol]
(R-ALL-74016)
Ca2+ [extracellular region]
(R-ALL-74112)
Ca2+ [endoplasmic reticulum lumen]
(R-ALL-111875)
0.655
10
UniProt:P01375 TNF
5
TNF(1-233) [plasma membrane]
(R-HSA-66220)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
0.618
4
zinc(2+) [ChEBI:29105]
20
Zn2+ [endocytic vesicle membrane]
(R-ALL-190019)
Zn2+ [clathrin-coated endocytic vesicle membrane]
(R-ALL-5228397)
Zn2+ [synaptic vesicle membrane]
(R-ALL-5228942)
Zn2+ [endosome membrane]
(R-ALL-5211336)
Zn2+ [synaptic vesicle]
(R-ALL-437093)
Zn2+ [secretory granule lumen]
(R-ALL-216785)
Zn2+ [endoplasmic reticulum lumen]
(R-ALL-442320)
Zn2+ [melanosome membrane]
(R-ALL-5668571)
Zn2+ [mitochondrial matrix]
(R-ALL-880067)
Zn2+ [lysosomal lumen]
(R-ALL-6799592)
Zn2+ [Golgi membrane]
(R-ALL-975815)
Zn2+ [Golgi lumen]
(R-ALL-216667)
Zn2+ [mitochondrial intermembrane space]
(R-ALL-3777117)
Zn2+ [phagocytic vesicle lumen]
(R-ALL-1562550)
Zn2+ [endosome lumen]
(R-ALL-435350)
Zn2+ [endoplasmic reticulum membrane]
(R-ALL-6788653)
Zn2+ [mitochondrial inner membrane]
(R-ALL-8949653)
Zn2+ [extracellular region]
(R-ALL-158417)
Zn2+ [cytosol]
(R-ALL-29426)
Zn2+ [plasma membrane]
(R-ALL-109265)
0.618
3
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