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What is Reactome ?
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Table of Contents
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Zn2+ [mitochondrial matrix]
Stable Identifier
R-ALL-880067
Type
Chemical Compound [SimpleEntity]
Compartment
mitochondrial matrix
Synonyms
Zn++, zinc(2+), Zinc ion, Zn(II)
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Aerobic respiration and respiratory electron transport (Bos taurus)
Citric acid cycle (TCA cycle) (Bos taurus)
Maturation of TCA enzymes and regulation of TCA cycle (Bos taurus)
SIRT3 deacetylates AcK-IDH2 dimer (Bos taurus)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Bos taurus)
Zn2+ [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Bos taurus)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Bos taurus)
Zn2+ [mitochondrial matrix]
Pyruvate metabolism (Bos taurus)
Regulation of pyruvate metabolism (Bos taurus)
Regulation of pyruvate dehydrogenase (PDH) complex (Bos taurus)
SIRT4 cleaves lipoyl from DLAT (Bos taurus)
SIRT4:Zn2+ [mitochondrial matrix] (Bos taurus)
Zn2+ [mitochondrial matrix]
Metabolism of amino acids and derivatives (Bos taurus)
Sulfur amino acid metabolism (Bos taurus)
Degradation of cysteine and homocysteine (Bos taurus)
Sulfide oxidation to sulfate (Bos taurus)
Persulfide sulfur is dioxygenated (Bos taurus)
ETHE1:2Zn2+ [mitochondrial matrix] (Bos taurus)
Zn2+ [mitochondrial matrix]
Reversible hydration of carbon dioxide (Bos taurus)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Bos taurus)
CA5A,B:Zinc [mitochondrial matrix] (Bos taurus)
CA5A:Zinc [mitochondrial matrix] (Bos taurus)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Bos taurus)
Zn2+ [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Bos taurus)
CA5A,B:Zinc [mitochondrial matrix] (Bos taurus)
CA5A:Zinc [mitochondrial matrix] (Bos taurus)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Bos taurus)
Zn2+ [mitochondrial matrix]
Organelle biogenesis and maintenance (Bos taurus)
Mitochondrial biogenesis (Bos taurus)
Transcriptional activation of mitochondrial biogenesis (Bos taurus)
SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Bos taurus)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Bos taurus)
Zn2+ [mitochondrial matrix]
SIRT4 transfers ADPRib to GLUD (Bos taurus)
SIRT4:Zn2+ [mitochondrial matrix] (Bos taurus)
Zn2+ [mitochondrial matrix]
Transport of small molecules (Bos taurus)
Mitochondrial calcium ion transport (Bos taurus)
Processing of SMDT1 (Bos taurus)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Bos taurus)
Mitochondrial processing peptidase [mitochondrial matrix] (Bos taurus)
PMPCB:Zn2+ [mitochondrial matrix] (Bos taurus)
Zn2+ [mitochondrial matrix]
Metabolism (Caenorhabditis elegans)
Aerobic respiration and respiratory electron transport (Caenorhabditis elegans)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Caenorhabditis elegans)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Caenorhabditis elegans)
Zn2+ [mitochondrial matrix]
Pyruvate metabolism (Caenorhabditis elegans)
Regulation of pyruvate metabolism (Caenorhabditis elegans)
Regulation of pyruvate dehydrogenase (PDH) complex (Caenorhabditis elegans)
SIRT4 cleaves lipoyl from DLAT (Caenorhabditis elegans)
SIRT4:Zn2+ [mitochondrial matrix] (Caenorhabditis elegans)
Zn2+ [mitochondrial matrix]
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Sulfur amino acid metabolism (Caenorhabditis elegans)
Degradation of cysteine and homocysteine (Caenorhabditis elegans)
Sulfide oxidation to sulfate (Caenorhabditis elegans)
Persulfide sulfur is dioxygenated (Caenorhabditis elegans)
ETHE1:2Zn2+ [mitochondrial matrix] (Caenorhabditis elegans)
Zn2+ [mitochondrial matrix]
Reversible hydration of carbon dioxide (Caenorhabditis elegans)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Caenorhabditis elegans)
CA5A,B:Zinc [mitochondrial matrix] (Caenorhabditis elegans)
CA5A:Zinc [mitochondrial matrix] (Caenorhabditis elegans)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Caenorhabditis elegans)
Zn2+ [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Caenorhabditis elegans)
CA5A,B:Zinc [mitochondrial matrix] (Caenorhabditis elegans)
CA5A:Zinc [mitochondrial matrix] (Caenorhabditis elegans)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Caenorhabditis elegans)
Zn2+ [mitochondrial matrix]
Organelle biogenesis and maintenance (Caenorhabditis elegans)
Mitochondrial biogenesis (Caenorhabditis elegans)
Transcriptional activation of mitochondrial biogenesis (Caenorhabditis elegans)
SIRT4 transfers ADPRib to GLUD (Caenorhabditis elegans)
SIRT4:Zn2+ [mitochondrial matrix] (Caenorhabditis elegans)
Zn2+ [mitochondrial matrix]
Transport of small molecules (Caenorhabditis elegans)
Mitochondrial calcium ion transport (Caenorhabditis elegans)
Processing of SMDT1 (Caenorhabditis elegans)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Caenorhabditis elegans)
Mitochondrial processing peptidase [mitochondrial matrix] (Caenorhabditis elegans)
PMPCB:Zn2+ [mitochondrial matrix] (Caenorhabditis elegans)
Zn2+ [mitochondrial matrix]
Metabolism (Canis familiaris)
Aerobic respiration and respiratory electron transport (Canis familiaris)
Citric acid cycle (TCA cycle) (Canis familiaris)
Maturation of TCA enzymes and regulation of TCA cycle (Canis familiaris)
SIRT3 deacetylates AcK-IDH2 dimer (Canis familiaris)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Canis familiaris)
Zn2+ [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Canis familiaris)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Canis familiaris)
Zn2+ [mitochondrial matrix]
Pyruvate metabolism (Canis familiaris)
Regulation of pyruvate metabolism (Canis familiaris)
Regulation of pyruvate dehydrogenase (PDH) complex (Canis familiaris)
SIRT4 cleaves lipoyl from DLAT (Canis familiaris)
SIRT4:Zn2+ [mitochondrial matrix] (Canis familiaris)
Zn2+ [mitochondrial matrix]
Metabolism of amino acids and derivatives (Canis familiaris)
Sulfur amino acid metabolism (Canis familiaris)
Degradation of cysteine and homocysteine (Canis familiaris)
Sulfide oxidation to sulfate (Canis familiaris)
Persulfide sulfur is dioxygenated (Canis familiaris)
ETHE1:2Zn2+ [mitochondrial matrix] (Canis familiaris)
Zn2+ [mitochondrial matrix]
Reversible hydration of carbon dioxide (Canis familiaris)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Canis familiaris)
CA5A,B:Zinc [mitochondrial matrix] (Canis familiaris)
CA5A:Zinc [mitochondrial matrix] (Canis familiaris)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Canis familiaris)
Zn2+ [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Canis familiaris)
CA5A,B:Zinc [mitochondrial matrix] (Canis familiaris)
CA5A:Zinc [mitochondrial matrix] (Canis familiaris)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Canis familiaris)
Zn2+ [mitochondrial matrix]
Organelle biogenesis and maintenance (Canis familiaris)
Mitochondrial biogenesis (Canis familiaris)
Transcriptional activation of mitochondrial biogenesis (Canis familiaris)
SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Canis familiaris)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Canis familiaris)
Zn2+ [mitochondrial matrix]
SIRT4 transfers ADPRib to GLUD (Canis familiaris)
SIRT4:Zn2+ [mitochondrial matrix] (Canis familiaris)
Zn2+ [mitochondrial matrix]
Transport of small molecules (Canis familiaris)
Mitochondrial calcium ion transport (Canis familiaris)
Processing of SMDT1 (Canis familiaris)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Canis familiaris)
Mitochondrial processing peptidase [mitochondrial matrix] (Canis familiaris)
PMPCB:Zn2+ [mitochondrial matrix] (Canis familiaris)
Zn2+ [mitochondrial matrix]
Metabolism (Danio rerio)
Aerobic respiration and respiratory electron transport (Danio rerio)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Danio rerio)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Danio rerio)
Zn2+ [mitochondrial matrix]
Pyruvate metabolism (Danio rerio)
Regulation of pyruvate metabolism (Danio rerio)
Regulation of pyruvate dehydrogenase (PDH) complex (Danio rerio)
SIRT4 cleaves lipoyl from DLAT (Danio rerio)
SIRT4:Zn2+ [mitochondrial matrix] (Danio rerio)
Zn2+ [mitochondrial matrix]
Metabolism of amino acids and derivatives (Danio rerio)
Sulfur amino acid metabolism (Danio rerio)
Degradation of cysteine and homocysteine (Danio rerio)
Sulfide oxidation to sulfate (Danio rerio)
Persulfide sulfur is dioxygenated (Danio rerio)
ETHE1:2Zn2+ [mitochondrial matrix] (Danio rerio)
Zn2+ [mitochondrial matrix]
Reversible hydration of carbon dioxide (Danio rerio)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Danio rerio)
CA5A,B:Zinc [mitochondrial matrix] (Danio rerio)
CA5A:Zinc [mitochondrial matrix] (Danio rerio)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Danio rerio)
Zn2+ [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Danio rerio)
CA5A,B:Zinc [mitochondrial matrix] (Danio rerio)
CA5A:Zinc [mitochondrial matrix] (Danio rerio)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Danio rerio)
Zn2+ [mitochondrial matrix]
Organelle biogenesis and maintenance (Danio rerio)
Mitochondrial biogenesis (Danio rerio)
Transcriptional activation of mitochondrial biogenesis (Danio rerio)
SIRT4 transfers ADPRib to GLUD (Danio rerio)
SIRT4:Zn2+ [mitochondrial matrix] (Danio rerio)
Zn2+ [mitochondrial matrix]
Metabolism (Dictyostelium discoideum)
Aerobic respiration and respiratory electron transport (Dictyostelium discoideum)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Dictyostelium discoideum)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Dictyostelium discoideum)
Zn2+ [mitochondrial matrix]
Organelle biogenesis and maintenance (Dictyostelium discoideum)
Mitochondrial biogenesis (Dictyostelium discoideum)
Transcriptional activation of mitochondrial biogenesis (Dictyostelium discoideum)
SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Dictyostelium discoideum)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Dictyostelium discoideum)
Zn2+ [mitochondrial matrix]
Metabolism (Drosophila melanogaster)
Aerobic respiration and respiratory electron transport (Drosophila melanogaster)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Drosophila melanogaster)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Drosophila melanogaster)
Zn2+ [mitochondrial matrix]
Pyruvate metabolism (Drosophila melanogaster)
Regulation of pyruvate metabolism (Drosophila melanogaster)
Regulation of pyruvate dehydrogenase (PDH) complex (Drosophila melanogaster)
SIRT4 cleaves lipoyl from DLAT (Drosophila melanogaster)
SIRT4:Zn2+ [mitochondrial matrix] (Drosophila melanogaster)
Zn2+ [mitochondrial matrix]
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Sulfur amino acid metabolism (Drosophila melanogaster)
Degradation of cysteine and homocysteine (Drosophila melanogaster)
Sulfide oxidation to sulfate (Drosophila melanogaster)
Persulfide sulfur is dioxygenated (Drosophila melanogaster)
ETHE1:2Zn2+ [mitochondrial matrix] (Drosophila melanogaster)
Zn2+ [mitochondrial matrix]
Reversible hydration of carbon dioxide (Drosophila melanogaster)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Drosophila melanogaster)
CA5A,B:Zinc [mitochondrial matrix] (Drosophila melanogaster)
CA5A:Zinc [mitochondrial matrix] (Drosophila melanogaster)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Drosophila melanogaster)
Zn2+ [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Drosophila melanogaster)
CA5A,B:Zinc [mitochondrial matrix] (Drosophila melanogaster)
CA5A:Zinc [mitochondrial matrix] (Drosophila melanogaster)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Drosophila melanogaster)
Zn2+ [mitochondrial matrix]
Organelle biogenesis and maintenance (Drosophila melanogaster)
Mitochondrial biogenesis (Drosophila melanogaster)
Transcriptional activation of mitochondrial biogenesis (Drosophila melanogaster)
SIRT4 transfers ADPRib to GLUD (Drosophila melanogaster)
SIRT4:Zn2+ [mitochondrial matrix] (Drosophila melanogaster)
Zn2+ [mitochondrial matrix]
Transport of small molecules (Drosophila melanogaster)
Mitochondrial calcium ion transport (Drosophila melanogaster)
Processing of SMDT1 (Drosophila melanogaster)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Drosophila melanogaster)
Mitochondrial processing peptidase [mitochondrial matrix] (Drosophila melanogaster)
PMPCB:Zn2+ [mitochondrial matrix] (Drosophila melanogaster)
Zn2+ [mitochondrial matrix]
Metabolism (Gallus gallus)
Aerobic respiration and respiratory electron transport (Gallus gallus)
Citric acid cycle (TCA cycle) (Gallus gallus)
Maturation of TCA enzymes and regulation of TCA cycle (Gallus gallus)
SIRT3 deacetylates AcK-IDH2 dimer (Gallus gallus)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Gallus gallus)
Zn2+ [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Gallus gallus)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Gallus gallus)
Zn2+ [mitochondrial matrix]
Pyruvate metabolism (Gallus gallus)
Regulation of pyruvate metabolism (Gallus gallus)
Regulation of pyruvate dehydrogenase (PDH) complex (Gallus gallus)
SIRT4 cleaves lipoyl from DLAT (Gallus gallus)
SIRT4:Zn2+ [mitochondrial matrix] (Gallus gallus)
Zn2+ [mitochondrial matrix]
Reversible hydration of carbon dioxide (Gallus gallus)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Gallus gallus)
CA5A,B:Zinc [mitochondrial matrix] (Gallus gallus)
CA5A:Zinc [mitochondrial matrix] (Gallus gallus)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Gallus gallus)
Zn2+ [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Gallus gallus)
CA5A,B:Zinc [mitochondrial matrix] (Gallus gallus)
CA5A:Zinc [mitochondrial matrix] (Gallus gallus)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Gallus gallus)
Zn2+ [mitochondrial matrix]
Organelle biogenesis and maintenance (Gallus gallus)
Mitochondrial biogenesis (Gallus gallus)
Transcriptional activation of mitochondrial biogenesis (Gallus gallus)
SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Gallus gallus)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Gallus gallus)
Zn2+ [mitochondrial matrix]
SIRT4 transfers ADPRib to GLUD (Gallus gallus)
SIRT4:Zn2+ [mitochondrial matrix] (Gallus gallus)
Zn2+ [mitochondrial matrix]
Transport of small molecules (Gallus gallus)
Mitochondrial calcium ion transport (Gallus gallus)
Processing of SMDT1 (Gallus gallus)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Gallus gallus)
Mitochondrial processing peptidase [mitochondrial matrix] (Gallus gallus)
PMPCB:Zn2+ [mitochondrial matrix] (Gallus gallus)
Zn2+ [mitochondrial matrix]
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
Maturation of TCA enzymes and regulation of TCA cycle (Homo sapiens)
SIRT3 deacetylates AcK-IDH2 dimer (Homo sapiens)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Homo sapiens)
Zn2+ [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Homo sapiens)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Homo sapiens)
Zn2+ [mitochondrial matrix]
Pyruvate metabolism (Homo sapiens)
Regulation of pyruvate metabolism (Homo sapiens)
Regulation of pyruvate dehydrogenase (PDH) complex (Homo sapiens)
SIRT4 cleaves lipoyl from DLAT (Homo sapiens)
SIRT4:Zn2+ [mitochondrial matrix] (Homo sapiens)
Zn2+ [mitochondrial matrix]
Metabolism of amino acids and derivatives (Homo sapiens)
Sulfur amino acid metabolism (Homo sapiens)
Degradation of cysteine and homocysteine (Homo sapiens)
Sulfide oxidation to sulfate (Homo sapiens)
Persulfide sulfur is dioxygenated (Homo sapiens)
ETHE1:2Zn2+ [mitochondrial matrix] (Homo sapiens)
Zn2+ [mitochondrial matrix]
Reversible hydration of carbon dioxide (Homo sapiens)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Homo sapiens)
CA5A,B:Zinc [mitochondrial matrix] (Homo sapiens)
CA5A:Zinc [mitochondrial matrix] (Homo sapiens)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Homo sapiens)
Zn2+ [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Homo sapiens)
CA5A,B:Zinc [mitochondrial matrix] (Homo sapiens)
CA5A:Zinc [mitochondrial matrix] (Homo sapiens)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Homo sapiens)
Zn2+ [mitochondrial matrix]
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Homo sapiens)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Homo sapiens)
Zn2+ [mitochondrial matrix]
SIRT4 transfers ADPRib to GLUD (Homo sapiens)
SIRT4:Zn2+ [mitochondrial matrix] (Homo sapiens)
Zn2+ [mitochondrial matrix]
Protein localization (Homo sapiens)
Mitochondrial protein import (Homo sapiens)
MPP cleaves targeting peptide (presequence) of inner membrane precursors (Homo sapiens)
Mitochondrial processing peptidase [mitochondrial matrix] (Homo sapiens)
PMPCB:Zn2+ [mitochondrial matrix] (Homo sapiens)
Zn2+ [mitochondrial matrix]
MPP cleaves targeting peptide (presequence) of matrix precursors (Homo sapiens)
Mitochondrial processing peptidase [mitochondrial matrix] (Homo sapiens)
PMPCB:Zn2+ [mitochondrial matrix] (Homo sapiens)
Zn2+ [mitochondrial matrix]
Transport of small molecules (Homo sapiens)
Mitochondrial calcium ion transport (Homo sapiens)
Processing of SMDT1 (Homo sapiens)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Homo sapiens)
Mitochondrial processing peptidase [mitochondrial matrix] (Homo sapiens)
PMPCB:Zn2+ [mitochondrial matrix] (Homo sapiens)
Zn2+ [mitochondrial matrix]
Metabolism (Mus musculus)
Aerobic respiration and respiratory electron transport (Mus musculus)
Citric acid cycle (TCA cycle) (Mus musculus)
Maturation of TCA enzymes and regulation of TCA cycle (Mus musculus)
SIRT3 deacetylates AcK-IDH2 dimer (Mus musculus)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Mus musculus)
Zn2+ [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Mus musculus)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Mus musculus)
Zn2+ [mitochondrial matrix]
Pyruvate metabolism (Mus musculus)
Regulation of pyruvate metabolism (Mus musculus)
Regulation of pyruvate dehydrogenase (PDH) complex (Mus musculus)
SIRT4 cleaves lipoyl from DLAT (Mus musculus)
SIRT4:Zn2+ [mitochondrial matrix] (Mus musculus)
Zn2+ [mitochondrial matrix]
Metabolism of amino acids and derivatives (Mus musculus)
Sulfur amino acid metabolism (Mus musculus)
Degradation of cysteine and homocysteine (Mus musculus)
Sulfide oxidation to sulfate (Mus musculus)
Persulfide sulfur is dioxygenated (Mus musculus)
ETHE1:2Zn2+ [mitochondrial matrix] (Mus musculus)
Zn2+ [mitochondrial matrix]
Reversible hydration of carbon dioxide (Mus musculus)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Mus musculus)
CA5A,B:Zinc [mitochondrial matrix] (Mus musculus)
CA5A:Zinc [mitochondrial matrix] (Mus musculus)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Mus musculus)
Zn2+ [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Mus musculus)
CA5A,B:Zinc [mitochondrial matrix] (Mus musculus)
CA5A:Zinc [mitochondrial matrix] (Mus musculus)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Mus musculus)
Zn2+ [mitochondrial matrix]
Organelle biogenesis and maintenance (Mus musculus)
Mitochondrial biogenesis (Mus musculus)
Transcriptional activation of mitochondrial biogenesis (Mus musculus)
SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Mus musculus)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Mus musculus)
Zn2+ [mitochondrial matrix]
SIRT4 transfers ADPRib to GLUD (Mus musculus)
SIRT4:Zn2+ [mitochondrial matrix] (Mus musculus)
Zn2+ [mitochondrial matrix]
Transport of small molecules (Mus musculus)
Mitochondrial calcium ion transport (Mus musculus)
Processing of SMDT1 (Mus musculus)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Mus musculus)
Mitochondrial processing peptidase [mitochondrial matrix] (Mus musculus)
PMPCB:Zn2+ [mitochondrial matrix] (Mus musculus)
Zn2+ [mitochondrial matrix]
Metabolism (Plasmodium falciparum)
Reversible hydration of carbon dioxide (Plasmodium falciparum)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Plasmodium falciparum)
CA5A,B:Zinc [mitochondrial matrix] (Plasmodium falciparum)
CA5A:Zinc [mitochondrial matrix] (Plasmodium falciparum)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Plasmodium falciparum)
Zn2+ [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Plasmodium falciparum)
CA5A,B:Zinc [mitochondrial matrix] (Plasmodium falciparum)
CA5A:Zinc [mitochondrial matrix] (Plasmodium falciparum)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Plasmodium falciparum)
Zn2+ [mitochondrial matrix]
Metabolism (Rattus norvegicus)
Aerobic respiration and respiratory electron transport (Rattus norvegicus)
Citric acid cycle (TCA cycle) (Rattus norvegicus)
Maturation of TCA enzymes and regulation of TCA cycle (Rattus norvegicus)
SIRT3 deacetylates AcK-IDH2 dimer (Rattus norvegicus)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Rattus norvegicus)
Zn2+ [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Rattus norvegicus)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Rattus norvegicus)
Zn2+ [mitochondrial matrix]
Pyruvate metabolism (Rattus norvegicus)
Regulation of pyruvate metabolism (Rattus norvegicus)
Regulation of pyruvate dehydrogenase (PDH) complex (Rattus norvegicus)
SIRT4 cleaves lipoyl from DLAT (Rattus norvegicus)
SIRT4:Zn2+ [mitochondrial matrix] (Rattus norvegicus)
Zn2+ [mitochondrial matrix]
Metabolism of amino acids and derivatives (Rattus norvegicus)
Sulfur amino acid metabolism (Rattus norvegicus)
Degradation of cysteine and homocysteine (Rattus norvegicus)
Sulfide oxidation to sulfate (Rattus norvegicus)
Persulfide sulfur is dioxygenated (Rattus norvegicus)
ETHE1:2Zn2+ [mitochondrial matrix] (Rattus norvegicus)
Zn2+ [mitochondrial matrix]
Reversible hydration of carbon dioxide (Rattus norvegicus)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Rattus norvegicus)
CA5A,B:Zinc [mitochondrial matrix] (Rattus norvegicus)
CA5A:Zinc [mitochondrial matrix] (Rattus norvegicus)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Rattus norvegicus)
Zn2+ [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Rattus norvegicus)
CA5A,B:Zinc [mitochondrial matrix] (Rattus norvegicus)
CA5A:Zinc [mitochondrial matrix] (Rattus norvegicus)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Rattus norvegicus)
Zn2+ [mitochondrial matrix]
Organelle biogenesis and maintenance (Rattus norvegicus)
Mitochondrial biogenesis (Rattus norvegicus)
Transcriptional activation of mitochondrial biogenesis (Rattus norvegicus)
SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Rattus norvegicus)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Rattus norvegicus)
Zn2+ [mitochondrial matrix]
SIRT4 transfers ADPRib to GLUD (Rattus norvegicus)
SIRT4:Zn2+ [mitochondrial matrix] (Rattus norvegicus)
Zn2+ [mitochondrial matrix]
Transport of small molecules (Rattus norvegicus)
Mitochondrial calcium ion transport (Rattus norvegicus)
Processing of SMDT1 (Rattus norvegicus)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Rattus norvegicus)
Mitochondrial processing peptidase [mitochondrial matrix] (Rattus norvegicus)
PMPCB:Zn2+ [mitochondrial matrix] (Rattus norvegicus)
Zn2+ [mitochondrial matrix]
Metabolism (Saccharomyces cerevisiae)
Aerobic respiration and respiratory electron transport (Saccharomyces cerevisiae)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Saccharomyces cerevisiae)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Saccharomyces cerevisiae)
Zn2+ [mitochondrial matrix]
Organelle biogenesis and maintenance (Saccharomyces cerevisiae)
Mitochondrial biogenesis (Saccharomyces cerevisiae)
Transcriptional activation of mitochondrial biogenesis (Saccharomyces cerevisiae)
SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Saccharomyces cerevisiae)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Saccharomyces cerevisiae)
Zn2+ [mitochondrial matrix]
Metabolism (Schizosaccharomyces pombe)
Aerobic respiration and respiratory electron transport (Schizosaccharomyces pombe)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Schizosaccharomyces pombe)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Schizosaccharomyces pombe)
Zn2+ [mitochondrial matrix]
Organelle biogenesis and maintenance (Schizosaccharomyces pombe)
Mitochondrial biogenesis (Schizosaccharomyces pombe)
Transcriptional activation of mitochondrial biogenesis (Schizosaccharomyces pombe)
SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Schizosaccharomyces pombe)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Schizosaccharomyces pombe)
Zn2+ [mitochondrial matrix]
Metabolism (Sus scrofa)
Aerobic respiration and respiratory electron transport (Sus scrofa)
Citric acid cycle (TCA cycle) (Sus scrofa)
Maturation of TCA enzymes and regulation of TCA cycle (Sus scrofa)
SIRT3 deacetylates AcK-IDH2 dimer (Sus scrofa)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Sus scrofa)
Zn2+ [mitochondrial matrix]
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Sus scrofa)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Sus scrofa)
Zn2+ [mitochondrial matrix]
Pyruvate metabolism (Sus scrofa)
Regulation of pyruvate metabolism (Sus scrofa)
Regulation of pyruvate dehydrogenase (PDH) complex (Sus scrofa)
SIRT4 cleaves lipoyl from DLAT (Sus scrofa)
SIRT4:Zn2+ [mitochondrial matrix] (Sus scrofa)
Zn2+ [mitochondrial matrix]
Metabolism of amino acids and derivatives (Sus scrofa)
Sulfur amino acid metabolism (Sus scrofa)
Degradation of cysteine and homocysteine (Sus scrofa)
Sulfide oxidation to sulfate (Sus scrofa)
Persulfide sulfur is dioxygenated (Sus scrofa)
ETHE1:2Zn2+ [mitochondrial matrix] (Sus scrofa)
Zn2+ [mitochondrial matrix]
Reversible hydration of carbon dioxide (Sus scrofa)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Sus scrofa)
CA5A,B:Zinc [mitochondrial matrix] (Sus scrofa)
CA5A:Zinc [mitochondrial matrix] (Sus scrofa)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Sus scrofa)
Zn2+ [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Sus scrofa)
CA5A,B:Zinc [mitochondrial matrix] (Sus scrofa)
CA5A:Zinc [mitochondrial matrix] (Sus scrofa)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Sus scrofa)
Zn2+ [mitochondrial matrix]
Organelle biogenesis and maintenance (Sus scrofa)
Mitochondrial biogenesis (Sus scrofa)
Transcriptional activation of mitochondrial biogenesis (Sus scrofa)
SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 (Sus scrofa)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Sus scrofa)
Zn2+ [mitochondrial matrix]
SIRT4 transfers ADPRib to GLUD (Sus scrofa)
SIRT4:Zn2+ [mitochondrial matrix] (Sus scrofa)
Zn2+ [mitochondrial matrix]
Transport of small molecules (Sus scrofa)
Mitochondrial calcium ion transport (Sus scrofa)
Processing of SMDT1 (Sus scrofa)
PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) (Sus scrofa)
Mitochondrial processing peptidase [mitochondrial matrix] (Sus scrofa)
PMPCB:Zn2+ [mitochondrial matrix] (Sus scrofa)
Zn2+ [mitochondrial matrix]
Metabolism (Xenopus tropicalis)
Aerobic respiration and respiratory electron transport (Xenopus tropicalis)
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (Xenopus tropicalis)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (Xenopus tropicalis)
Zn2+ [mitochondrial matrix]
Pyruvate metabolism (Xenopus tropicalis)
Regulation of pyruvate metabolism (Xenopus tropicalis)
Regulation of pyruvate dehydrogenase (PDH) complex (Xenopus tropicalis)
SIRT4 cleaves lipoyl from DLAT (Xenopus tropicalis)
SIRT4:Zn2+ [mitochondrial matrix] (Xenopus tropicalis)
Zn2+ [mitochondrial matrix]
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Sulfur amino acid metabolism (Xenopus tropicalis)
Degradation of cysteine and homocysteine (Xenopus tropicalis)
Sulfide oxidation to sulfate (Xenopus tropicalis)
Persulfide sulfur is dioxygenated (Xenopus tropicalis)
ETHE1:2Zn2+ [mitochondrial matrix] (Xenopus tropicalis)
Zn2+ [mitochondrial matrix]
Reversible hydration of carbon dioxide (Xenopus tropicalis)
Carbonic anhydrase dehydrates bicarbonate (mitochondria) (Xenopus tropicalis)
CA5A,B:Zinc [mitochondrial matrix] (Xenopus tropicalis)
CA5A:Zinc [mitochondrial matrix] (Xenopus tropicalis)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Xenopus tropicalis)
Zn2+ [mitochondrial matrix]
Carbonic anhydrase hydrates carbon dioxide (mitochondria) (Xenopus tropicalis)
CA5A,B:Zinc [mitochondrial matrix] (Xenopus tropicalis)
CA5A:Zinc [mitochondrial matrix] (Xenopus tropicalis)
Zn2+ [mitochondrial matrix]
CA5B:Zinc [mitochondrial matrix] (Xenopus tropicalis)
Zn2+ [mitochondrial matrix]
Organelle biogenesis and maintenance (Xenopus tropicalis)
Mitochondrial biogenesis (Xenopus tropicalis)
Transcriptional activation of mitochondrial biogenesis (Xenopus tropicalis)
SIRT4 transfers ADPRib to GLUD (Xenopus tropicalis)
SIRT4:Zn2+ [mitochondrial matrix] (Xenopus tropicalis)
Zn2+ [mitochondrial matrix]
External Reference Information
External Reference
zinc(2+) [ChEBI:29105]
Participates
as a component of
MAS1:Zn2+ [mitochondrial matrix] (Saccharomyces cerevisiae)
CA5B:Zinc [mitochondrial matrix] (Plasmodium falciparum)
CA5B:Zinc [mitochondrial matrix] (Xenopus tropicalis)
CA5B:Zinc [mitochondrial matrix] (Bos taurus)
CA5B:Zinc [mitochondrial matrix] (Danio rerio)
CA5B:Zinc [mitochondrial matrix] (Drosophila melanogaster)
CA5B:Zinc [mitochondrial matrix] (Canis familiaris)
CA5B:Zinc [mitochondrial matrix] (Mus musculus)
CA5B:Zinc [mitochondrial matrix] (Caenorhabditis elegans)
CA5B:Zinc [mitochondrial matrix] (Gallus gallus)
CA5B:Zinc [mitochondrial matrix] (Rattus norvegicus)
CA5B:Zinc [mitochondrial matrix] (Sus scrofa)
CA5B:Zinc [mitochondrial matrix] (Homo sapiens)
CA5A:Zinc [mitochondrial matrix] (Mus musculus)
CA5A:Zinc [mitochondrial matrix] (Caenorhabditis elegans)
CA5A:Zinc [mitochondrial matrix] (Xenopus tropicalis)
CA5A:Zinc [mitochondrial matrix] (Sus scrofa)
CA5A:Zinc [mitochondrial matrix] (Drosophila melanogaster)
CA5A:Zinc [mitochondrial matrix] (Plasmodium falciparum)
CA5A:Zinc [mitochondrial matrix] (Gallus gallus)
CA5A:Zinc [mitochondrial matrix] (Danio rerio)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Rattus norvegicus)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Homo sapiens)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Sus scrofa)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Gallus gallus)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Saccharomyces cerevisiae)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Mus musculus)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Bos taurus)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Dictyostelium discoideum)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Schizosaccharomyces pombe)
SIRT3(?-399):Zn2+ [mitochondrial matrix] (Canis familiaris)
SIRT4:Zn2+ [mitochondrial matrix] (Homo sapiens)
SIRT4:Zn2+ [mitochondrial matrix] (Bos taurus)
SIRT4:Zn2+ [mitochondrial matrix] (Danio rerio)
SIRT4:Zn2+ [mitochondrial matrix] (Caenorhabditis elegans)
SIRT4:Zn2+ [mitochondrial matrix] (Xenopus tropicalis)
SIRT4:Zn2+ [mitochondrial matrix] (Drosophila melanogaster)
SIRT4:Zn2+ [mitochondrial matrix] (Rattus norvegicus)
SIRT4:Zn2+ [mitochondrial matrix] (Gallus gallus)
SIRT4:Zn2+ [mitochondrial matrix] (Mus musculus)
SIRT4:Zn2+ [mitochondrial matrix] (Canis familiaris)
SIRT4:Zn2+ [mitochondrial matrix] (Sus scrofa)
ETHE1:2Zn2+ [mitochondrial matrix] (Homo sapiens)
ETHE1:2Zn2+ [mitochondrial matrix] (Danio rerio)
ETHE1:2Zn2+ [mitochondrial matrix] (Bos taurus)
ETHE1:2Zn2+ [mitochondrial matrix] (Sus scrofa)
ETHE1:2Zn2+ [mitochondrial matrix] (Xenopus tropicalis)
ETHE1:2Zn2+ [mitochondrial matrix] (Canis familiaris)
ETHE1:2Zn2+ [mitochondrial matrix] (Caenorhabditis elegans)
ETHE1:2Zn2+ [mitochondrial matrix] (Rattus norvegicus)
ETHE1:2Zn2+ [mitochondrial matrix] (Mus musculus)
ETHE1:2Zn2+ [mitochondrial matrix] (Drosophila melanogaster)
PMPCB:Zn2+ [mitochondrial matrix] (Homo sapiens)
PMPCB:Zn2+ [mitochondrial matrix] (Canis familiaris)
PMPCB:Zn2+ [mitochondrial matrix] (Caenorhabditis elegans)
PMPCB:Zn2+ [mitochondrial matrix] (Bos taurus)
PMPCB:Zn2+ [mitochondrial matrix] (Sus scrofa)
PMPCB:Zn2+ [mitochondrial matrix] (Gallus gallus)
PMPCB:Zn2+ [mitochondrial matrix] (Mus musculus)
PMPCB:Zn2+ [mitochondrial matrix] (Drosophila melanogaster)
PMPCB:Zn2+ [mitochondrial matrix] (Rattus norvegicus)
CA5A:Zinc [mitochondrial matrix] (Homo sapiens)
CA5A:Zinc [mitochondrial matrix] (Rattus norvegicus)
CA5A:Zinc [mitochondrial matrix] (Bos taurus)
CA5A:Zinc [mitochondrial matrix] (Canis familiaris)
This entity regulates
Positively
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
(Saccharomyces cerevisiae)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
(Schizosaccharomyces pombe)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
(Dictyostelium discoideum)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
(Caenorhabditis elegans)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
(Drosophila melanogaster)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
(Gallus gallus)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
(Xenopus tropicalis)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
(Danio rerio)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
(Sus scrofa)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
(Bos taurus)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
(Canis familiaris)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
(Mus musculus)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
(Homo sapiens)
(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
(Rattus norvegicus)
Other forms of this molecule
Zn2+ [endocytic vesicle membrane]
Zn2+ [clathrin-coated endocytic vesicle membrane]
Zn2+ [synaptic vesicle membrane]
Zn2+ [endosome membrane]
Zn2+ [synaptic vesicle]
Zn2+ [secretory granule lumen]
Zn2+ [endoplasmic reticulum lumen]
Zn2+ [Golgi membrane]
Zn2+ [lysosomal lumen]
Zn2+ [melanosome membrane]
Zn2+ [Golgi lumen]
Zn2+ [mitochondrial intermembrane space]
Zn2+ [phagocytic vesicle lumen]
Zn2+ [endosome lumen]
Zn2+ [endoplasmic reticulum membrane]
Zn2+ [mitochondrial inner membrane]
Zn2+ [extracellular region]
Zn2+ [cytosol]
Zn2+ [plasma membrane]
Zn2+ [nucleoplasm]
Cross References
COMPOUND
C00038
PubChem Substance
11533263
HMDB Metabolite
HMDB0015532
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