Reactome | S100A12 [secretory granule lumen]

S100A12 [secretory granule lumen]

Stable Identifier

R-HSA-6804789

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

Protein S100-A12, S10AC_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P80511 S100A12

Gene Names

S100A12

Chain

initiator methionine:1, chain:2-92, peptide:78-92

Reference Genes

BioGPS Gene:6283 S100A12

COSMIC (genes):S100A12 S100A12

CTD Gene:6283 S100A12

dbSNP Gene:6283 S100A12

ENSEMBL:ENSG00000163221.9 S100A12

HGNC:10489 S100A12

KEGG Gene (Homo sapiens):6283 S100A12

Monarch:6283 S100A12

NCBI Gene:6283 S100A12

OMIM:603112 S100A12

UCSC:P80511 S100A12

Reference Transcript

RefSeq:NM_005621.1 S100A12

Other Identifiers

0002320056

11725138_at

16693409

205863_PM_at

205863_at

2435982

2435983

2435984

2435985

38879_at

6283

7920238

A_23_P74001

A_33_P3385785

D83657_at

GE57334

GO:0002376

GO:0002548

GO:0005507

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006351

GO:0006355

GO:0006805

GO:0006954

GO:0008270

GO:0016020

GO:0023052

GO:0030593

GO:0031410

GO:0031640

GO:0034774

GO:0036211

GO:0042742

GO:0042802

GO:0043123

GO:0043226

GO:0043406

GO:0045087

GO:0045576

GO:0046872

GO:0048306

GO:0048870

GO:0050729

GO:0050786

GO:0050832

GO:0051092

GO:0061844

GO:0098542

HMNXSV003000001

ILMN_1748915

PH_hs_0001709

TC01003260.hg

g5032058_3p_at

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

S100A12 [extracellular region]

Inferred To

Homologues of S100A12 [secretory granule lumen] (Sus scrofa)

Homologues of S100A12 [secretory granule lumen] (Xenopus tropicalis)

s100p [secretory granule lumen] (Xenopus tropicalis)

S100A12 [secretory granule lumen] (Bos taurus)

S100A12 [secretory granule lumen] (Canis familiaris)

S100A12 [secretory granule lumen] (Gallus gallus)

S100A12 [secretory granule lumen] (Sus scrofa)

S100A12 [secretory granule lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_005612.1

OpenTargets

ENSG00000163221

HPA

ENSG00000163221-S100A12

GeneCards

P80511

Ensembl

ENSP00000357726, ENST00000368737, ENSG00000163221

PRO

P80511

Pharos - Targets

P80511

PDB

1ODB, 1GQM, 2WC8, 2M9G, 2WCE, 2WCF, 1E8A, 2WCB

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
calcium(2+) [ChEBI:29108]	20	Ca2+ [platelet dense granule lumen] (R-ALL-114582) Ca2+ [endosome membrane] (R-ALL-5210949) Ca2+ [sarcoplasmic reticulum lumen] (R-ALL-2855229) Ca2+ [mitochondrial intermembrane space] (R-ALL-8949232) Ca2+ [mitochondrial matrix] (R-ALL-8949220) Ca2+ [endocytic vesicle lumen] (R-ALL-8851519) Ca2+ [lysosomal lumen] (R-ALL-1606834) Ca2+ [endoplasmic reticulum-Golgi intermediate compartment] (R-ALL-9706979) Ca2+ [Golgi lumen] (R-ALL-167012) Ca2+ [platelet dense tubular network lumen] (R-ALL-139827) Ca2+ [platelet dense tubular network membrane] (R-ALL-141090) Ca2+ [plasma membrane] (R-ALL-140648) Ca2+ [secretory granule lumen] (R-ALL-216801) Ca2+ [nuclear envelope] (R-ALL-2318767) Ca2+ [nucleoplasm] (R-ALL-29496) Ca2+ [mitochondrial inner membrane] (R-ALL-1524102) Ca2+ [endoplasmic reticulum membrane] (R-ALL-1500625) Ca2+ [endoplasmic reticulum lumen] (R-ALL-111875) Ca2+ [cytosol] (R-ALL-74016) Ca2+ [extracellular region] (R-ALL-74112)	0.655	10
zinc(2+) [ChEBI:29105]	20	Zn2+ [endocytic vesicle membrane] (R-ALL-190019) Zn2+ [clathrin-coated endocytic vesicle membrane] (R-ALL-5228397) Zn2+ [synaptic vesicle membrane] (R-ALL-5228942) Zn2+ [endosome membrane] (R-ALL-5211336) Zn2+ [synaptic vesicle] (R-ALL-437093) Zn2+ [secretory granule lumen] (R-ALL-216785) Zn2+ [endoplasmic reticulum lumen] (R-ALL-442320) Zn2+ [mitochondrial inner membrane] (R-ALL-8949653) Zn2+ [phagocytic vesicle lumen] (R-ALL-1562550) Zn2+ [endosome lumen] (R-ALL-435350) Zn2+ [Golgi membrane] (R-ALL-975815) Zn2+ [lysosomal lumen] (R-ALL-6799592) Zn2+ [melanosome membrane] (R-ALL-5668571) Zn2+ [mitochondrial matrix] (R-ALL-880067) Zn2+ [Golgi lumen] (R-ALL-216667) Zn2+ [mitochondrial intermembrane space] (R-ALL-3777117) Zn2+ [endoplasmic reticulum membrane] (R-ALL-6788653) Zn2+ [extracellular region] (R-ALL-158417) Zn2+ [cytosol] (R-ALL-29426) Zn2+ [plasma membrane] (R-ALL-109265)	0.618	3

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