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IFNA2 [extracellular region]
Stable Identifier
R-HSA-877349
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interferon alpha-2, IFNA2_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Expression of Interferon-alpha and beta (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Activation of JAK kinases (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
Formation of p-STAT1 homodimer (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
IFN alpha/beta binds to IFNAR2 (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
Phosphorylation of INFAR1 by TYK2 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
Phosphorylation of STAT1 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
Phosphorylation of STAT2 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
Recruitment of IFNAR1 (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
Recruitment of STAT2 to p-IFNAR1 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
Regulation of IFNA signaling (Homo sapiens)
Dephosphorylation of JAK1 by SHP1 (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
Dephosphorylation of STAT1 by SHP2 (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:STAT1 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
Dephosphorylation of TYK2 by PTP1B (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
Inhibition of JAK kinase activity by SOCS1/3 (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
Release of p-STAT2:p-STAT1 dimer (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
Innate Immune System (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated IRF7 activation (Homo sapiens)
Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 (Homo sapiens)
IFN alpha/beta (IFNA/B) [extracellular region] (Homo sapiens)
IFNA [extracellular region] (Homo sapiens)
IFNA2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01563 IFNA2
Gene Names
IFNA2, IFNA2A, IFNA2B, IFNA2C
Chain
signal peptide:1-23, chain:24-188
Reference Genes
BioGPS Gene:3440 IFNA2
COSMIC (genes):IFNA2 IFNA2
CTD Gene:3440 IFNA2
dbSNP Gene:3440 IFNA2
ENSEMBL:ENSG00000188379 IFNA2
HGNC:5423 IFNA2
KEGG Gene (Homo sapiens):3440 IFNA2
Monarch:3440 IFNA2
NCBI Gene:3440 IFNA2
OMIM:147562 IFNA2
UCSC:P01563 IFNA2
Reference Transcript
RefSeq:NM_000605.3 IFNA2
Other Identifiers
0003870204
11738377_at
11738378_x_at
17092866
1791_s_at
211338_at
3201320
3201321
3201322
3201323
3201324
3201325
3440
8160422
A_23_P250251
GE566074
GO:0002250
GO:0002286
GO:0002323
GO:0002376
GO:0003674
GO:0005125
GO:0005126
GO:0005132
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0006464
GO:0006915
GO:0006950
GO:0006952
GO:0006954
GO:0006959
GO:0007155
GO:0007165
GO:0007166
GO:0007267
GO:0007596
GO:0008150
GO:0008219
GO:0008283
GO:0009058
GO:0010629
GO:0019221
GO:0030154
GO:0030183
GO:0031012
GO:0032696
GO:0032714
GO:0033141
GO:0034641
GO:0042100
GO:0042327
GO:0042531
GO:0043330
GO:0044403
GO:0045581
GO:0045892
GO:0045893
GO:0046597
GO:0048856
GO:0051607
GO:0060337
GO:0062023
GO:2000552
HMNXSV003023787
ILMN_1698186
J00207_rna2_at
PH_hs_0032186
TC09000960.hg
g10800141_3p_s_at
g184598_3p_s_at
g186407_3p_s_at
g186498_3p_at
Participates
as a member of
IFNA [extracellular region] (Homo sapiens)
Inferred To
Ifna14 [extracellular region]
(Mus musculus)
Ifna12 [extracellular region]
(Mus musculus)
IFNAG [extracellular region]
(Bos taurus)
LOC618947 [extracellular region]
(Bos taurus)
ifnphi3 [extracellular region]
(Danio rerio)
Ifna16 [extracellular region]
(Mus musculus)
ifnphi1 [extracellular region]
(Danio rerio)
Ifna1 [extracellular region]
(Mus musculus)
Ifna1 [extracellular region]
(Rattus norvegicus)
LOC100858762 [extracellular region]
(Gallus gallus)
IFNKL1 [extracellular region]
(Gallus gallus)
Ifna7 [extracellular region]
(Mus musculus)
Ifna5 [extracellular region]
(Mus musculus)
ifnphi4 [extracellular region]
(Danio rerio)
IFNA [extracellular region]
(Gallus gallus)
LOC100687692 [extracellular region]
(Canis familiaris)
LOC523244 [extracellular region]
(Bos taurus)
Ifnab [extracellular region]
(Mus musculus)
Ifna13 [extracellular region]
(Mus musculus)
Ifna15 [extracellular region]
(Mus musculus)
IFNAD [extracellular region]
(Bos taurus)
LOC776018 [extracellular region]
(Gallus gallus)
ifn-a [extracellular region]
(Canis familiaris)
Ifna11 [extracellular region]
(Mus musculus)
ifnphi2 [extracellular region]
(Danio rerio)
Ifna9 [extracellular region]
(Mus musculus)
Ifna4 [extracellular region]
(Mus musculus)
Ifna4 [extracellular region]
(Rattus norvegicus)
RGD1560539 [extracellular region]
(Rattus norvegicus)
Ifna16l1 [extracellular region]
(Rattus norvegicus)
LOC100335490 [extracellular region]
(Bos taurus)
Ifna2 [extracellular region]
(Mus musculus)
Ifna2 [extracellular region]
(Rattus norvegicus)
LOC768614 [extracellular region]
(Gallus gallus)
Homologues of IFNA2 [extracellular region]
(Bos taurus)
Homologues of IFNA2 [extracellular region]
(Canis familiaris)
Homologues of IFNA2 [extracellular region]
(Danio rerio)
Homologues of IFNA2 [extracellular region]
(Gallus gallus)
Homologues of IFNA2 [extracellular region]
(Mus musculus)
Homologues of IFNA2 [extracellular region]
(Rattus norvegicus)
Homologues of IFNA2 [extracellular region]
(Sus scrofa)
Homologues of IFNA2 [extracellular region]
(Xenopus tropicalis)
LOC100683567 [extracellular region]
(Canis familiaris)
LOC100687857 [extracellular region]
(Canis familiaris)
IFNA2 [extracellular region]
(Canis familiaris)
IFNA2 [extracellular region]
(Gallus gallus)
IFNA2 [extracellular region]
(Rattus norvegicus)
IFNA2 [extracellular region]
(Sus scrofa)
IFNA2 [extracellular region]
(Xenopus tropicalis)
Ifna6 [extracellular region]
(Mus musculus)
CaIFN-alpha 7 [extracellular region]
(Canis familiaris)
ifn4 [extracellular region]
(Xenopus tropicalis)
IFNB [extracellular region]
(Gallus gallus)
LOC100912314 [extracellular region]
(Rattus norvegicus)
LOC100912356 [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_000596.2
OpenTargets
ENSG00000188379
HPA
ENSG00000188379-IFNA2
GeneCards
P01563
Ensembl
ENST00000380206
,
ENSP00000369554
,
ENSG00000188379
PRO
P01563
Pharos - Targets
P01563
GlyGen
P01563
PDB
2HYM
,
2LAG
,
3SE3
,
4YPG
,
4Z5R
,
2KZ1
,
2LMS
,
1ITF
,
2HIE
,
1RH2
,
3S9D
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NPL8 TIMMDC1
1
TIMMDC1 [mitochondrial inner membrane]
(R-HSA-5689720)
0.556
3
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