Reactome | LOC120103159 [extracellular region]

LOC120103159 [extracellular region]

Stable Identifier

R-RNO-877349-8

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

extracellular region

Synonyms

IFNA2, A0A8I6GMD9

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Interferon Signaling (Rattus norvegicus)
    - Interferon alpha/beta signaling (Rattus norvegicus)
      - Activation of JAK kinases (Rattus norvegicus)
        
        IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
        
        p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
      - Formation of p-STAT1 homodimer (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
      - IFN alpha/beta binds to IFNAR2 (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
      - Phosphorylation of INFAR1 by TYK2 (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
      - Phosphorylation of STAT2 (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
      - Recruitment of IFNAR1 (Rattus norvegicus)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
      - Recruitment of STAT2 to p-IFNAR1 (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
      - Regulation of IFNA/IFNB signaling (Rattus norvegicus)
        
        Dephosphorylation of JAK1 by SHP1 (Rattus norvegicus)
        
        IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
        
        Dephosphorylation of STAT1 by SHP2 (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:STAT1 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
        
        Dephosphorylation of TYK2 by PTP1B (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
      - Release of p-STAT2:p-STAT1 dimer (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103159 [extracellular region] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A8I6GMD9

Gene Names

LOC120103159

Reference Genes

ENSEMBL:ENSRNOG00000069770

ENSEMBL:ENSRNOG00000069770.1 LOC120103159

Other Identifiers

10869877

10869879

10869882

120103159

17799767

17799769

5694260

5697464

5742558

5997567

6067187

6343230

6507757

6531399

A_44_P208733

A_64_P004247

GO:0005126

GO:0005576

GO:0006952

ILMN_1356073

Participates

as a member of

Homologues of IFNA2 [extracellular region] (Rattus norvegicus)

Other forms of this molecule

LOC120103159 [extracellular region]

Inferred From

IFNA2 [extracellular region] (Homo sapiens)

Cross References

Ensembl

ENSRNOT00000104040, ENSRNOG00000069770, ENSRNOP00000097109

RGD

41164037

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