Reactome | K164-PCNA-G157-ISG15 [nucleoplasm]

K164-PCNA-G157-ISG15 [nucleoplasm]

Stable Identifier

R-HSA-5653745

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Damage Bypass (Homo sapiens)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
    - Termination of translesion DNA synthesis (Homo sapiens)
      - UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Homo sapiens)
        
        DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        MonoUb:K164,ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
        
        K164-PCNA-G157-ISG15 [nucleoplasm] (Homo sapiens)
      - USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)
        
        DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        MonoUb:K164,ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
        
        K164-PCNA-G157-ISG15 [nucleoplasm] (Homo sapiens)
        
        USP10:DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        MonoUb:K164,ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
        
        K164-PCNA-G157-ISG15 [nucleoplasm] (Homo sapiens)
      - USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
        
        K164-PCNA-G157-ISG15 [nucleoplasm] (Homo sapiens)
        
        USP10:DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        MonoUb:K164,ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
        
        K164-PCNA-G157-ISG15 [nucleoplasm] (Homo sapiens)
      - USP43 binds ISG:K164,ISG:K168-PCNA (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
        
        K164-PCNA-G157-ISG15 [nucleoplasm] (Homo sapiens)
        
        USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
        
        K164-PCNA-G157-ISG15 [nucleoplasm] (Homo sapiens)
      - USP43 deISGylates ISG:K164,ISG:K168-PCNA (Homo sapiens)
        
        USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
        
        K164-PCNA-G157-ISG15 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P05161 ISG15

Gene Names

ISG15, G1P2, UCRP

Chain

initiator methionine:1, chain:2-157, propeptide:158-165

Reference Genes

BioGPS Gene:9636 ISG15

COSMIC (genes):ISG15 ISG15

CTD Gene:9636 ISG15

dbSNP Gene:9636 ISG15

ENSEMBL:ENSG00000187608 ISG15

HGNC:4053 ISG15

KEGG Gene (Homo sapiens):9636 ISG15

Monarch:9636 ISG15

NCBI Gene:9636 ISG15

OMIM:147571 ISG15

UCSC:P05161 ISG15

Reference Transcript

RefSeq:NM_005101.3 ISG15

Other Identifiers

0004590398

1107_s_at

11716895_s_at

16657594

205483_PM_s_at

205483_s_at

38432_at

4053544

4053545

4053546

4053547

4053548

4053549

7896817

9636

A_23_P819

GE62795

GO:0002376

GO:0003674

GO:0003735

GO:0005178

GO:0005198

GO:0005515

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005840

GO:0006464

GO:0006950

GO:0007165

GO:0007229

GO:0008150

GO:0009056

GO:0009615

GO:0009617

GO:0019899

GO:0019941

GO:0022607

GO:0022627

GO:0030154

GO:0030501

GO:0031386

GO:0031397

GO:0031625

GO:0032020

GO:0032461

GO:0032649

GO:0032728

GO:0032729

GO:0032733

GO:0032991

GO:0034340

GO:0042592

GO:0042742

GO:0043226

GO:0045071

GO:0045087

GO:0045648

GO:0048856

GO:0051607

GO:0060339

GO:0065003

GO:0070585

HMNXSV003047646

ILMN_1813289

ILMN_2054019

M13755_at

PH_hs_0028539

TC01000023.hg

g4826773_3p_a_at

Participates

as a component of

ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)

Other forms of this molecule

ISG15 [nucleoplasm]

ISG15 [cytosol]

K168-PCNA-G157-ISG15 [nucleoplasm]

Inferred To

Isg15 [nucleoplasm] (Mus musculus)

Isg15 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of K164-PCNA-G157-ISG15 [nucleoplasm] (Danio rerio)

Ghost homologue of K164-PCNA-G157-ISG15 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of K164-PCNA-G157-ISG15 [nucleoplasm] (Gallus gallus)

Ghost homologue of K164-PCNA-G157-ISG15 [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of K164-PCNA-G157-ISG15 [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of K164-PCNA-G157-ISG15 [nucleoplasm] (Xenopus tropicalis)

ISG15 [nucleoplasm] (Bos taurus)

ISG15 [nucleoplasm] (Canis familiaris)

ISG15 [nucleoplasm] (Sus scrofa)

K164-PCNA-G157-ISG15 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

Inter-chain Crosslink via N6-glycyl-L-lysine at 157 and 164

Coordinate

157

PsiMod Name

N6-glycyl-L-lysine

PsiMod Definition

A protein modification that effectively crosslinks an L-lysine residue and a glycine residue by an isopeptide bond to form N6-glycyl-L-lysine.

Cross References

RefSeq

NP_005092.1

OpenTargets

ENSG00000187608

HPA

ENSG00000187608-ISG15

GeneCards

P05161

Ensembl

ENSG00000187608, ENST00000649529, ENSP00000496832

PRO

P05161

Pharos - Targets

P05161

Orphanet

21556

PDB

6XA9, 2HJ8, 1Z2M, 7S6P, 6FFA, 5W8T, 3SDL, 5TL6, 5W8U, 3RT3, 3PHX, 3R66, 6BI8, 3PSE, 7RBS

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTD1-PRO_0000449621 REP			0.907	13
UniProt:Q9UMW8 USP18	1	USP18 [cytosol] (R-HSA-912325)	0.873	9
UniProt:P41226 UBA7	2	UBA7 [nucleoplasm] (R-HSA-5653762) UBA7 [cytosol] (R-HSA-936550)	0.836	10
UniProt:Q6TQR6 L			0.743	5
UniProt:P0C6U8-PRO_0000338257			0.719	5
UniProt:K9N7C7-PRO_0000422441 REP			0.655	4
UniProt:P03502 NS1			0.65	4
UniProt:Q9BYX4 IFIH1	3	PolyUb-IFIH1 [cytosol] (R-HSA-6782812) K48polyUb-IFIH1 [cytosol] (R-HSA-3080557) IFIH1 [cytosol] (R-HSA-913536)	0.623	7
UniProt:K0BWD0 K0BWD0			0.618	4
UniProt:P03495 NS1			0.602	4
UniProt:O75369 FLNB	1	FLNB [cytosol] (R-HSA-354163)	0.591	4
UniProt:O75688 PPM1B	3	PPM1B(2-282)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713477) PPM1B(2-282)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9713479) PPM1B [cytosol] (R-HSA-1169375)	0.558	2
UniProt:O60260-5 PRKN			0.556	3
UniProt:P0C6X7-PRO_0000037311 REP			0.544	2